SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LAD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 7 GLY A 418
GLY A 477
PHE A 297
PHE A 319
 GOL  A 605 (-4.0A)
LAD  A 601 (-3.4A)
None
None
 0.88A 2qwxA-1e1tA:
undetectable
2qwxB-1e1tA:
undetectable		 2qwxA-1e1tA:
18.50
2qwxB-1e1tA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 7 ARG A 251
PHE A 250
ILE A 198
ASN A 200
 LAD  A1584 (-2.3A)
None
None
None
 1.23A 2zseA-4up7A:
undetectable		 2zseA-4up7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 GLN A 451
HIS A 462
ASP A 450
GLU A 229
PRO A 457
 None
None
None
LAD  A1584 (-3.6A)
None
 1.40A 3b7pA-4up7A:
undetectable		 3b7pA-4up7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 249
ARG A 251
GLU A 267
ALA A 459
GLU A 487
 None
LAD  A1584 (-2.3A)
LAD  A1584 (-3.3A)
None
LAD  A1584 (-2.6A)
 1.13A 3k37A-4up7A:
undetectable		 3k37A-4up7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 7 ARG A 186
GLY A 423
ILE A 422
THR A 275
 None
LAD  A 601 ( 3.7A)
None
GOL  A 606 ( 4.4A)
 0.82A 3spkB-1e1tA:
0.0		 3spkB-1e1tA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 11 PHE A 297
PHE A 415
ILE A 476
GLY A 477
LEU A 484
 None
None
None
LAD  A 601 (-3.4A)
None
 1.15A 3t3rA-1e1tA:
0.0		 3t3rA-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 11 PHE A 297
PHE A 485
PHE A 415
ILE A 476
GLY A 477
 None
None
None
None
LAD  A 601 (-3.4A)
 1.11A 3t3rA-1e1tA:
0.0		 3t3rA-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 PHE A 297
PHE A 485
PHE A 415
ILE A 476
GLY A 477
 None
None
None
None
LAD  A 601 (-3.4A)
 1.17A 3t3rD-1e1tA:
0.0		 3t3rD-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 ARG A 262
PHE A 274
GLY A 423
ARG A 480
 LAD  A 601 ( 2.6A)
LAD  A 601 (-3.4A)
LAD  A 601 ( 3.7A)
POP  A 602 ( 2.4A)
 0.43A 4k87A-1e1tA:
10.8		 4k87A-1e1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		4 / 8 ARG A 251
PHE A 263
GLY A 534
THR A 265
 LAD  A1584 (-2.3A)
LAD  A1584 (-3.5A)
LAD  A1584 ( 3.9A)
LAD  A1584 (-4.5A)
 0.82A 4k87A-4up7A:
10.9		 4k87A-4up7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 12 LEU A 249
ARG A 251
GLU A 267
ALA A 459
GLU A 487
 None
LAD  A1584 (-2.3A)
LAD  A1584 (-3.3A)
None
LAD  A1584 (-2.6A)
 1.30A 4mx0A-4up7A:
undetectable		 4mx0A-4up7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
MG  A 603 (-2.7A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.40A 6bniA-1e1tA:
46.9		 6bniA-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.42A 6bniA-1e1tA:
46.9		 6bniA-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		7 / 10 ARG A 251
GLU A 253
HIS A 259
PHE A 263
GLY A 536
ARG A 539
ILE A 550
 LAD  A1584 (-2.3A)
LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
LAD  A1584 (-3.5A)
LAD  A1584 ( 3.7A)
LAD  A1584 (-4.1A)
None
 0.35A 6bniA-4up7A:
48.3		 6bniA-4up7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 10 GLU A 253
HIS A 259
GLU A 480
ARG A 539
ILE A 550
 LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
None
LAD  A1584 (-4.1A)
None
 1.07A 6bniA-4up7A:
48.3		 6bniA-4up7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
MG  A 603 (-2.7A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.37A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.41A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 ASN A 260
ARG A 262
PHE A 274
GLY A 477
ILE A 495
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
None
 1.23A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		7 / 10 ARG A 251
GLU A 253
HIS A 259
PHE A 263
GLY A 536
ARG A 539
ILE A 550
 LAD  A1584 (-2.3A)
LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
LAD  A1584 (-3.5A)
LAD  A1584 ( 3.7A)
LAD  A1584 (-4.1A)
None
 0.34A 6bniB-4up7A:
48.5		 6bniB-4up7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4up7 LYSINE--TRNA LIGASE
(Entamoeba
histolytica) 		5 / 10 GLU A 253
HIS A 259
GLU A 480
ARG A 539
ILE A 550
 LAD  A1584 (-4.1A)
LAD  A1584 (-4.1A)
None
LAD  A1584 (-4.1A)
None
 1.08A 6bniB-4up7A:
48.5		 6bniB-4up7A:
6.92