SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LAC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 TYR A 298
TYR A 297
TYR A  51
HIS A  77
 None
LAC  A 399 ( 4.1A)
PPI  A 453 ( 4.7A)
None
 1.30A 2ha2A-3kb6A:
undetectable		 2ha2A-3kb6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 TYR A 298
TYR A 297
TYR A  51
HIS A  77
 None
LAC  A 399 ( 4.1A)
PPI  A 453 ( 4.7A)
None
 1.38A 2ha2B-3kb6A:
undetectable		 2ha2B-3kb6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA
(Staphylococcus
aureus) 		5 / 9 GLY A 200
SER A 206
LEU A 208
LEU A 180
ASP A 177
 None
None
None
LAC  A 401 ( 4.8A)
LAC  A 401 ( 3.9A)
 1.43A 2j2pB-5xr2A:
undetectable
2j2pC-5xr2A:
undetectable		 2j2pB-5xr2A:
21.04
2j2pC-5xr2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 ILE A 287
PHE A  98
PRO A 220
PHE A 228
 None
LAC  A 401 (-4.0A)
None
None
 1.09A 2ygnA-2zzwA:
undetectable		 2ygnA-2zzwA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 GLY A  48
MET A 252
PHE A 217
ASN A  96
 None
None
LAC  A 401 ( 4.6A)
None
 1.30A 3uq6B-2zzwA:
undetectable		 3uq6B-2zzwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 LEU A 265
ASP A  52
PHE A  49
SER A  72
THR A   6
 None
None
PPI  A 398 (-4.0A)
LAC  A 399 (-4.3A)
None
 1.12A 4eckB-3kb6A:
2.3		 4eckB-3kb6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 MET A 106
ASP A 253
PHE A  98
 None
None
LAC  A 401 (-4.0A)
 0.97A 4xeyA-2zzwA:
undetectable		 4xeyA-2zzwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 MET A 106
ASP A 253
PHE A  98
 None
None
LAC  A 401 (-4.0A)
 0.99A 4xeyB-2zzwA:
undetectable		 4xeyB-2zzwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 PHE A  81
GLY A 181
TYR A 101
ARG A 178
 None
None
LAC  A 401 (-4.4A)
LAC  A 401 (-2.9A)
 1.15A 4yshB-2zzwA:
undetectable		 4yshB-2zzwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 TYR A  51
ASP A 255
HIS A 294
TYR A  96
 PPI  A 453 ( 4.7A)
NAD  A 400 (-4.1A)
LAC  A 399 (-3.9A)
LAC  A 399 ( 4.6A)
 1.09A 5ih0A-3kb6A:
undetectable		 5ih0A-3kb6A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A 159
LEU A 226
ASN A 223
PHE A 217
PHE A  98
 None
None
None
LAC  A 401 ( 4.6A)
LAC  A 401 (-4.0A)
 1.42A 6dwnB-2zzwA:
undetectable		 6dwnB-2zzwA:
11.08