SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LA6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5uv2 (+)-LIMONENE
SYNTHASE
(Citrus
sinensis) 		5 / 11 PHE A 484
THR A 446
THR A 340
ASP A 488
ILE A 445
 LA6  A 704 (-4.6A)
LA6  A 704 (-3.5A)
LA6  A 704 (-3.4A)
MN  A 703 ( 2.8A)
None
 0.98A 1phgA-5uv2A:
undetectable		 1phgA-5uv2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5uv2 (+)-LIMONENE
SYNTHASE
(Citrus
sinensis) 		3 / 3 ASP A 489
PHE A 484
ASN A 440
 None
LA6  A 704 (-4.6A)
None
 0.86A 1sg9B-5uv2A:
undetectable		 1sg9B-5uv2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5uv2 (+)-LIMONENE
SYNTHASE
(Citrus
sinensis) 		4 / 8 GLU A 422
GLN A 507
ARG A 485
ASP A 489
 MN  A 702 ( 4.5A)
None
LA6  A 704 (-2.9A)
None
 1.19A 3mjrD-5uv2A:
undetectable		 3mjrD-5uv2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDR_A_210A822_1
(ALPHA-BISABOLENE
SYNTHASE)		 5uv2 (+)-LIMONENE
SYNTHASE
(Citrus
sinensis) 		4 / 4 ASP A 343
ASP A 347
ARG A 485
ASP A 488
 MN  A 702 (-2.7A)
MN  A 701 (-2.7A)
LA6  A 704 (-2.9A)
MN  A 703 ( 2.8A)
 0.62A 3sdrA-5uv2A:
38.8		 3sdrA-5uv2A:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 5uv2 (+)-LIMONENE
SYNTHASE
(Citrus
sinensis) 		4 / 4 ASP A 343
ASP A 347
ARG A 485
ASP A 488
 MN  A 702 (-2.7A)
MN  A 701 (-2.7A)
LA6  A 704 (-2.9A)
MN  A 703 ( 2.8A)
 0.62A 3sdvA-5uv2A:
38.0		 3sdvA-5uv2A:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5uv2 (+)-LIMONENE
SYNTHASE
(Citrus
sinensis) 		4 / 5 ARG A 485
LEU A 438
PRO A 432
ASP A 489
 LA6  A 704 (-2.9A)
None
None
None
 1.11A 3ufnA-5uv2A:
undetectable
3ufnB-5uv2A:
undetectable		 3ufnA-5uv2A:
10.90
3ufnB-5uv2A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		7 / 9 ASP A  81
ARG A 174
ASN A 220
SER A 224
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.69A 5dz2A-5nx7A:
38.8		 5dz2A-5nx7A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		7 / 9 ASP A  81
ARG A 174
ASN A 220
SER A 224
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.66A 5dz2B-5nx7A:
39.0		 5dz2B-5nx7A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		8 / 10 ASP A  81
ARG A 174
ASN A 220
SER A 224
LYS A 227
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
0FV  A 400 ( 2.5A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.56A 5ermA-5nx7A:
22.5		 5ermA-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		5 / 10 ASP A  81
ASP A  85
LYS A 227
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
MG  A 403 ( 4.6A)
0FV  A 400 ( 2.5A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.88A 5ermA-5nx7A:
22.5		 5ermA-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		8 / 9 ASP A  81
ARG A 174
ASN A 220
SER A 224
LYS A 227
GLU A 228
ARG A 314
TYR A 315
 MG  A 404 (-2.6A)
0FV  A 400 ( 3.0A)
0FV  A 400 (-2.7A)
MG  A 402 (-2.2A)
0FV  A 400 ( 2.5A)
MG  A 402 (-2.6A)
LA6  A 401 ( 3.8A)
0FV  A 400 ( 4.4A)
 0.47A 5ermB-5nx7A:
9.1		 5ermB-5nx7A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5nx7 PENTALENENE SYNTHASE
(Streptomyces
clavuligerus) 		4 / 5 ASN A 217
ASP A 221
ASN A 236
ASP A 233
 LA6  A 401 (-4.4A)
None
None
None
 1.45A 5vooC-5nx7A:
undetectable		 5vooC-5nx7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5uv2 (+)-LIMONENE
SYNTHASE
(Citrus
sinensis) 		4 / 5 LEU A 385
LEU A 449
THR A 340
ARG A 329
 None
None
LA6  A 704 (-3.4A)
None
 0.95A 6ew0F-5uv2A:
undetectable		 6ew0F-5uv2A:
8.83