SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L9R'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3l9r CD1B3
(Bos
taurus) 		5 / 7 LEU A 161
THR A 165
LEU A 170
GLY A 101
LEU A  12
 None
None
None
None
L9R  A 284 ( 4.1A)
 1.16A 1gtiA-3l9rA:
undetectable		 1gtiA-3l9rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 3l9r CD1B3
(Bos
taurus) 		5 / 7 LEU A 161
THR A 165
LEU A 170
GLY A 101
LEU A  12
 None
None
None
None
L9R  A 284 ( 4.1A)
 1.30A 1gtiB-3l9rA:
undetectable		 1gtiB-3l9rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3l9r CD1B3
(Bos
taurus) 		4 / 7 THR A 165
LEU A 170
GLY A 101
LEU A  12
 None
None
None
L9R  A 284 ( 4.1A)
 1.04A 1gtiE-3l9rA:
undetectable		 1gtiE-3l9rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		5 / 12 ALA A  32
LEU A  83
ILE A  85
PHE A  70
PHE A  51
 None
None
L9R  A 301 (-4.6A)
L9R  A 301 ( 4.3A)
None
 1.37A 1y0xX-3m7oA:
undetectable		 1y0xX-3m7oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		4 / 8 TYR A 145
ASP A  84
SER A  98
TYR A  97
 BEN  A 165 (-3.4A)
BEN  A 163 ( 3.2A)
BEN  A 163 ( 3.4A)
L9R  A 301 ( 3.5A)
 0.95A 2bteA-3m7oA:
undetectable		 2bteA-3m7oA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		4 / 8 TYR A 145
ASP A  84
SER A  98
TYR A  97
 BEN  A 165 (-3.4A)
BEN  A 163 ( 3.2A)
BEN  A 163 ( 3.4A)
L9R  A 301 ( 3.5A)
 0.95A 2bteD-3m7oA:
undetectable		 2bteD-3m7oA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		4 / 8 TYR A 145
ASP A  84
SER A  98
TYR A  97
 BEN  A 165 (-3.4A)
BEN  A 163 ( 3.2A)
BEN  A 163 ( 3.4A)
L9R  A 301 ( 3.5A)
 0.94A 2v0gA-3m7oA:
undetectable		 2v0gA-3m7oA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3l9r CD1B3
(Bos
taurus) 		5 / 12 LEU A 104
GLY A  30
LEU A 181
LEU A 174
VAL A 173
 None
L9R  A 284 ( 4.8A)
None
None
None
 0.97A 3adxB-3l9rA:
undetectable		 3adxB-3l9rA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3l9r CD1B3
(Bos
taurus) 		5 / 12 LEU A 118
PHE A 144
PHE A  94
VAL A  81
PHE A  77
 L9R  A 284 ( 4.4A)
L9R  A 284 (-4.4A)
None
L9R  A 284 ( 4.0A)
L9R  A 284 (-4.8A)
 1.49A 3nuvA-3l9rA:
undetectable		 3nuvA-3l9rA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l9r CD1B3
(Bos
taurus) 		5 / 10 SER A  16
PHE A  18
LEU A 114
VAL A 124
PHE A 144
 None
None
None
None
L9R  A 284 (-4.4A)
 1.45A 3u9fK-3l9rA:
undetectable		 3u9fK-3l9rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3l9r CD1B3
(Bos
taurus) 		5 / 12 TYR A 212
GLY A   6
LEU A  50
GLY A  30
ASP A  34
 None
None
None
L9R  A 284 ( 4.8A)
None
 1.14A 4blvB-3l9rA:
undetectable		 4blvB-3l9rA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		5 / 12 LEU A  53
LEU A 142
ALA A 157
VAL A  40
ALA A  32
 None
L9R  A 301 (-4.0A)
None
None
None
 1.17A 4x1iB-3m7oA:
undetectable		 4x1iB-3m7oA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		5 / 12 LEU A  53
LEU A 142
ALA A 157
VAL A  40
ALA A  32
 None
L9R  A 301 (-4.0A)
None
None
None
 1.01A 4x1yD-3m7oA:
undetectable		 4x1yD-3m7oA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		4 / 7 VAL A  40
LEU A  38
ALA A  32
LEU A 142
 None
None
None
L9R  A 301 (-4.0A)
 0.66A 5jq7A-3m7oA:
undetectable		 5jq7A-3m7oA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		5 / 10 PRO A 107
LEU A  81
PHE A 111
ALA A 153
PHE A  70
 None
None
None
L9R  A 301 (-3.6A)
L9R  A 301 ( 4.3A)
 0.89A 5m0oA-3m7oA:
undetectable		 5m0oA-3m7oA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3m7o LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		4 / 8 LEU A  81
PHE A 111
ALA A 153
PHE A  70
 None
None
L9R  A 301 (-3.6A)
L9R  A 301 ( 4.3A)
 0.68A 5m0oC-3m7oA:
undetectable		 5m0oC-3m7oA:
14.91