SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L6I'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 376
GLY A 603
SER A 363
GLY A 379
GLY A 378
 None
L6I  A1615 (-3.3A)
L6I  A1615 (-2.9A)
None
None
 0.92A 3douA-5fnuA:
undetectable		 3douA-5fnuA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 574
VAL A 568
GLY A 571
SER A 555
ALA A 522
 None
None
None
L6I  A1615 (-2.7A)
None
 1.12A 3keeB-5fnuA:
undetectable		 3keeB-5fnuA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 5 GLY A 379
ASP A 389
ARG A 415
GLN A 337
 None
None
L6I  A1615 (-4.0A)
None
 1.46A 3qx3A-5fnuA:
undetectable		 3qx3A-5fnuA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 605
GLY A 462
GLY A 603
VAL A 377
ILE A 416
 None
L6I  A1615 ( 3.2A)
L6I  A1615 (-3.3A)
None
None
 1.00A 4q5mA-5fnuA:
undetectable		 4q5mA-5fnuA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 556
GLY A 524
ILE A 519
ALA A 466
GLY A 464
 L6I  A1615 (-2.9A)
None
None
None
None
 1.06A 4r29D-5fnuA:
undetectable		 4r29D-5fnuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
L6I  A1615 (-3.0A)
None
 1.06A 5c0oE-5fnuA:
undetectable		 5c0oE-5fnuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
L6I  A1615 (-3.0A)
None
 0.91A 5c0oH-5fnuA:
undetectable		 5c0oH-5fnuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 12 GLY A 605
LEU A 557
LEU A 358
GLY A 379
GLY A 509
 None
None
None
None
L6I  A1615 (-3.0A)
 1.10A 5d4uB-5fnuA:
undetectable		 5d4uB-5fnuA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		4 / 4 LEU A 365
GLY A 364
SER A 363
SER A 338
 None
L6I  A1615 (-3.1A)
L6I  A1615 (-2.9A)
None
 1.22A 5uunB-5fnuA:
undetectable		 5uunB-5fnuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		5 / 9 GLY A 603
ALA A 556
GLY A 333
LEU A 339
SER A 338
 L6I  A1615 (-3.3A)
L6I  A1615 (-2.9A)
None
None
None
 1.24A 5vw4A-5fnuA:
undetectable		 5vw4A-5fnuA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Mus
musculus) 		3 / 3 HIS A 436
ARG A 415
ILE A 461
 None
L6I  A1615 (-4.0A)
None
 0.76A 6fgdA-5fnuA:
undetectable		 6fgdA-5fnuA:
21.61