SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L5P'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA2)	4wxz	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Geobacillus kaustophilus)	4 / 6	SER A 104 ARG A 147 GLY A 214 GLY A 153	L5P A 81 ( 3.8A) None L5P A 81 ( 3.7A) L5P A 81 ( 3.8A)	0.86A	4koeA-4wxzA: undetectable 4koeB-4wxzA: undetectable 4koeC-4wxzA: undetectable	4koeA-4wxzA: 21.33 4koeB-4wxzA: 21.33 4koeC-4wxzA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA4)	4wxz	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Geobacillus kaustophilus)	4 / 7	ARG A 147 SER A 104 GLY A 214 GLY A 153	None L5P A 81 ( 3.8A) L5P A 81 ( 3.7A) L5P A 81 ( 3.8A)	0.86A	4koeA-4wxzA: undetectable 4koeB-4wxzA: undetectable 4koeD-4wxzA: undetectable	4koeA-4wxzA: 21.33 4koeB-4wxzA: 21.33 4koeD-4wxzA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R38_C_RBFC201_2 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	4wxz	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Geobacillus kaustophilus)	5 / 9	ILE A 116 LEU A 45 LEU A 93 ILE A 67 PHE A 125	None L5P A 81 ( 4.8A) None None None	1.32A	4r38C-4wxzA: undetectable	4r38C-4wxzA: 19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	4wxz	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Geobacillus kaustophilus)	4 / 6	GLY A 214 GLY A 153 SER A 104 ARG A 147	L5P A 81 ( 3.7A) L5P A 81 ( 3.8A) L5P A 81 ( 3.8A) None	0.83A	4z53A-4wxzA: undetectable 4z53B-4wxzA: undetectable	4z53A-4wxzA: 18.45 4z53B-4wxzA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	4wxz	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Geobacillus kaustophilus)	4 / 7	ARG A 147 GLY A 214 GLY A 153 SER A 104	None L5P A 81 ( 3.7A) L5P A 81 ( 3.8A) L5P A 81 ( 3.8A)	0.81A	4z53A-4wxzA: undetectable 4z53B-4wxzA: undetectable	4z53A-4wxzA: 18.45 4z53B-4wxzA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_B_SAMB301_0 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	4wxz	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Geobacillus kaustophilus)	5 / 12	ALA A 211 GLY A 231 ALA A 160 ALA A 221 PRO A 152	None None None None L5P A 81 ( 4.2A)	1.02A	5jglB-4wxzA: undetectable	5jglB-4wxzA: 19.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4KOE_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA2","4wxz","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Geobacillus kaustophilus",4,"SER A 104;ARG A 147;GLY A 214;GLY A 153","L5P A  81 ( 3.8A);None;L5P A  81 ( 3.7A);L5P A  81 ( 3.8A)","0.86A","4koeA-4wxzA:undetectable;4koeB-4wxzA:undetectable;4koeC-4wxzA:undetectable",null],["4KOE_H_TR6H101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA4","4wxz","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Geobacillus kaustophilus",4,"ARG A 147;SER A 104;GLY A 214;GLY A 153","None;L5P A  81 ( 3.8A);L5P A  81 ( 3.7A);L5P A  81 ( 3.8A)","0.86A","4koeA-4wxzA:undetectable;4koeB-4wxzA:undetectable;4koeD-4wxzA:undetectable","4koeA-4wxzA:21.33;4koeB-4wxzA:21.33;4koeC-4wxzA:21.67"],["4R38_C_RBFC201_2","BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2","4wxz","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Geobacillus kaustophilus",5,"ILE A 116;LEU A  45;LEU A  93;ILE A  67;PHE A 125","None;L5P A  81 ( 4.8A);None;None;None","1.32A","4r38C-4wxzA:undetectable","4koeA-4wxzA:21.33;4koeB-4wxzA:21.33;4koeD-4wxzA:21.67"],["4Z53_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","4wxz","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Geobacillus kaustophilus",4,"GLY A 214;GLY A 153;SER A 104;ARG A 147","L5P A  81 ( 3.7A);L5P A  81 ( 3.8A);L5P A  81 ( 3.8A);None","0.83A","4z53A-4wxzA:undetectable;4z53B-4wxzA:undetectable","4r38C-4wxzA:19.66"],["4Z53_H_TR6H101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","4wxz","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Geobacillus kaustophilus",4,"ARG A 147;GLY A 214;GLY A 153;SER A 104","None;L5P A  81 ( 3.7A);L5P A  81 ( 3.8A);L5P A  81 ( 3.8A)","0.81A","4z53A-4wxzA:undetectable;4z53B-4wxzA:undetectable","4z53A-4wxzA:18.45;4z53B-4wxzA:18.45"],["5JGL_B_SAMB301_0","UBIE\/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE","4wxz","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Geobacillus kaustophilus",5,"ALA A 211;GLY A 231;ALA A 160;ALA A 221;PRO A 152","None;None;None;None;L5P A  81 ( 4.2A)","1.02A","5jglB-4wxzA:undetectable","4z53A-4wxzA:18.45;4z53B-4wxzA:18.45"]]