SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4G_B_ZMRB466_1 (NEURAMINIDASE)	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	5 / 12	ARG A 149 GLU A 434 ARG A 307 ASN A 432 TYR A 253	PEG A1775 ( 2.9A) L42 A1784 (-3.5A) L42 A1784 (-3.4A) GOL A1773 (-3.7A) L42 A1784 ( 3.4A)	1.45A	1a4gB-2wdaA: undetectable	1a4gB-2wdaA: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F9G_A_ASCA950_0 (HYALURONATE LYASE)	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	5 / 7	ARG A 149 ASN A 139 ARG A 307 ARG A 311 ASN A 432	PEG A1775 ( 2.9A) GOL A1773 (-2.8A) L42 A1784 (-3.4A) L42 A1784 (-2.8A) GOL A1773 (-3.7A)	1.34A	1f9gA-2wdaA: 43.4	1f9gA-2wdaA: 25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F9G_A_ASCA950_0 (HYALURONATE LYASE)	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	4 / 7	ARG A 149 TYR A 249 ARG A 307 ARG A 311	PEG A1775 ( 2.9A) None L42 A1784 (-3.4A) L42 A1784 (-2.8A)	1.17A	1f9gA-2wdaA: 43.4	1f9gA-2wdaA: 25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F9G_A_ASCA950_0 (HYALURONATE LYASE)	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	6 / 7	ASN A 139 TRP A 141 TYR A 253 ARG A 307 ARG A 311 ASN A 432	GOL A1773 (-2.8A) L42 A1784 (-3.8A) L42 A1784 ( 3.4A) L42 A1784 (-3.4A) L42 A1784 (-2.8A) GOL A1773 (-3.7A)	0.51A	1f9gA-2wdaA: 43.4	1f9gA-2wdaA: 25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KXH_A_ACRA598_1 (ALPHA-AMYLASE)	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	5 / 12	GLN A 243 VAL A 256 GLY A 254 ALA A 308 GLU A 434	None PEG A1775 (-3.8A) None L42 A1784 ( 4.9A) L42 A1784 (-3.5A)	1.20A	1kxhA-2wdaA: 3.9	1kxhA-2wdaA: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_H_377H401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	4 / 6	ASN A 139 GLU A 434 GLU A 429 TYR A 253	GOL A1773 (-2.8A) L42 A1784 (-3.5A) None L42 A1784 ( 3.4A)	1.47A	4twdG-2wdaA: undetectable 4twdH-2wdaA: undetectable	4twdG-2wdaA: 16.36 4twdH-2wdaA: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YSH_B_GLYB402_0 (GLYCINE OXIDASE)	2wda	PUTATIVE SECRETED LYASE (Streptomyces violaceoruber)	4 / 5	GLU A 429 TYR A 253 ARG A 311 ARG A 307	None L42 A1784 ( 3.4A) L42 A1784 (-2.8A) L42 A1784 (-3.4A)	1.29A	4yshB-2wdaA: 0.0	4yshB-2wdaA: 21.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A4G_B_ZMRB466_1","NEURAMINIDASE","2wda","PUTATIVE SECRETED LYASE","Streptomyces violaceoruber",5,"ARG A 149;GLU A 434;ARG A 307;ASN A 432;TYR A 253","PEG A1775 ( 2.9A);L42 A1784 (-3.5A);L42 A1784 (-3.4A);GOL A1773 (-3.7A);L42 A1784 ( 3.4A)","1.45A","1a4gB-2wdaA:undetectable",null],["1F9G_A_ASCA950_0","HYALURONATE LYASE","2wda","PUTATIVE SECRETED LYASE","Streptomyces violaceoruber",5,"ARG A 149;ASN A 139;ARG A 307;ARG A 311;ASN A 432","PEG A1775 ( 2.9A);GOL A1773 (-2.8A);L42 A1784 (-3.4A);L42 A1784 (-2.8A);GOL A1773 (-3.7A)","1.34A","1f9gA-2wdaA:43.4","1a4gB-2wdaA:19.14"],["1F9G_A_ASCA950_0","HYALURONATE LYASE","2wda","PUTATIVE SECRETED LYASE","Streptomyces violaceoruber",4,"ARG A 149;TYR A 249;ARG A 307;ARG A 311","PEG A1775 ( 2.9A);None;L42 A1784 (-3.4A);L42 A1784 (-2.8A)","1.17A","1f9gA-2wdaA:43.4","1f9gA-2wdaA:25.52"],["1F9G_A_ASCA950_0","HYALURONATE LYASE","2wda","PUTATIVE SECRETED LYASE","Streptomyces violaceoruber",6,"ASN A 139;TRP A 141;TYR A 253;ARG A 307;ARG A 311;ASN A 432","GOL A1773 (-2.8A);L42 A1784 (-3.8A);L42 A1784 ( 3.4A);L42 A1784 (-3.4A);L42 A1784 (-2.8A);GOL A1773 (-3.7A)","0.51A","1f9gA-2wdaA:43.4","1f9gA-2wdaA:25.52"],["1KXH_A_ACRA598_1","ALPHA-AMYLASE","2wda","PUTATIVE SECRETED LYASE","Streptomyces violaceoruber",5,"GLN A 243;VAL A 256;GLY A 254;ALA A 308;GLU A 434","None;PEG A1775 (-3.8A);None;L42 A1784 ( 4.9A);L42 A1784 (-3.5A)","1.20A","1kxhA-2wdaA:3.9","1f9gA-2wdaA:25.52"],["4TWD_H_377H401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","2wda","PUTATIVE SECRETED LYASE","Streptomyces violaceoruber",4,"ASN A 139;GLU A 434;GLU A 429;TYR A 253","GOL A1773 (-2.8A);L42 A1784 (-3.5A);None;L42 A1784 ( 3.4A)","1.47A","4twdG-2wdaA:undetectable;4twdH-2wdaA:undetectable","1kxhA-2wdaA:20.10"],["4YSH_B_GLYB402_0","GLYCINE OXIDASE","2wda","PUTATIVE SECRETED LYASE","Streptomyces violaceoruber",4,"GLU A 429;TYR A 253;ARG A 311;ARG A 307","None;L42 A1784 ( 3.4A);L42 A1784 (-2.8A);L42 A1784 (-3.4A)","1.29A","4yshB-2wdaA:0.0","4twdG-2wdaA:16.36;4twdH-2wdaA:16.36"]]