SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L3A'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 11 LEU A 201
HIS A 150
HIS A 212
ILE A 225
PHE A 248
 None
EDO  A 409 ( 3.7A)
ZN  A 403 ( 3.3A)
None
L3A  A 401 (-4.4A)
 1.50A 1fmjA-3s2jA:
0.0		 1fmjA-3s2jA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 ASP A  22
GLU A 123
HIS A 191
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
ZN  A 402 (-2.4A)
ZN  A 403 ( 3.2A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.33A 1ituA-3s2jA:
57.9		 1ituA-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		9 / 12 ASP A  22
TYR A  68
GLU A 123
HIS A 150
HIS A 191
HIS A 212
ARG A 223
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 403 ( 3.2A)
ZN  A 403 ( 3.3A)
L3A  A 401 (-4.0A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 0.44A 1ituA-3s2jA:
57.9		 1ituA-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		6 / 12 TYR A  68
GLU A 123
HIS A 150
HIS A  20
ASP A 320
PRO A 325
 L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 402 ( 3.3A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.17A 1ituA-3s2jA:
57.9		 1ituA-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 ASP A  22
GLU A 123
HIS A 191
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
ZN  A 402 (-2.4A)
ZN  A 403 ( 3.2A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.31A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		9 / 12 ASP A  22
TYR A  68
GLU A 123
HIS A 150
HIS A 191
HIS A 212
ARG A 223
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 403 ( 3.2A)
ZN  A 403 ( 3.3A)
L3A  A 401 (-4.0A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 0.45A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 GLU A 123
HIS A 191
HIS A  20
ASP A 320
VAL A 245
 ZN  A 402 (-2.4A)
ZN  A 403 ( 3.2A)
ZN  A 402 ( 3.3A)
L3A  A 401 (-3.1A)
None
 1.43A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		6 / 12 TYR A  68
GLU A 123
HIS A 150
HIS A  20
ASP A 320
PRO A 325
 L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 402 ( 3.3A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.16A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 6 TYR A 145
ASP A 320
HIS A  20
ILE A 317
 None
L3A  A 401 (-3.1A)
ZN  A 402 ( 3.3A)
None
 1.00A 5ih0A-3s2jA:
undetectable		 5ih0A-3s2jA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 7 TRP A  25
SER A  66
HIS A 150
GLY A 124
 L3A  A 401 (-4.4A)
ZN  A 402 ( 3.9A)
EDO  A 409 ( 3.7A)
None
 1.06A 6btxA-3s2jA:
undetectable		 6btxA-3s2jA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 6 ASN A 151
ASP A 152
SER A  71
ARG A  70
 L3A  A 401 (-4.7A)
EDO  A 409 (-3.3A)
EDO  A 409 (-3.2A)
None
 1.10A 6dwdA-3s2jA:
undetectable
6dwdC-3s2jA:
undetectable		 6dwdA-3s2jA:
21.93
6dwdC-3s2jA:
21.93