SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_A_SVRA508_2 (PHOSPHOLIPASE A2)	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	5 / 9	VAL A 308 GLY A 310 PRO A 314 THR A 316 GLY A 179	None L34 A 402 (-3.6A) L34 A 402 (-4.5A) NAD A 401 (-3.2A) None	1.21A	3bjwG-5tc4A: undetectable	3bjwG-5tc4A: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	5 / 12	GLN A 132 LEU A 133 PRO A 134 ASP A 155 THR A 176	L34 A 402 (-3.4A) L34 A 402 (-4.1A) None L34 A 402 (-2.9A) NAD A 401 (-3.2A)	0.80A	6debB-5tc4A: 41.6	6debB-5tc4A: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	10 / 12	LEU A 130 GLN A 132 LEU A 133 PRO A 134 ASP A 155 PHE A 157 THR A 176 SER A 202 VAL A 205 THR A 316	L34 A 402 ( 4.7A) L34 A 402 (-3.4A) L34 A 402 (-4.1A) None L34 A 402 (-2.9A) L34 A 402 (-4.9A) NAD A 401 (-3.2A) NAD A 401 (-2.4A) NAD A 401 (-4.1A) NAD A 401 (-3.2A)	0.63A	6debB-5tc4A: 41.6	6debB-5tc4A: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	5 / 12	LEU A 130 LEU A 133 PRO A 134 ASP A 155 THR A 316	L34 A 402 ( 4.7A) L34 A 402 (-4.1A) None L34 A 402 (-2.9A) NAD A 401 (-3.2A)	0.97A	6debB-5tc4A: 41.6	6debB-5tc4A: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB303_1 (BIFUNCTIONAL PROTEIN FOLD)	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	4 / 5	LYS A 88 GLN A 132 GLY A 255 ILE A 276	L34 A 402 (-2.8A) L34 A 402 (-3.4A) NAD A 401 (-3.2A) NAD A 401 ( 3.2A)	0.95A	6debB-5tc4A: 41.6	6debB-5tc4A: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB303_1 (BIFUNCTIONAL PROTEIN FOLD)	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	4 / 5	TYR A 84 LYS A 88 GLN A 132 GLY A 255	L34 A 402 (-3.4A) L34 A 402 (-2.8A) L34 A 402 (-3.4A) NAD A 401 (-3.2A)	0.47A	6debB-5tc4A: 41.6	6debB-5tc4A: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB303_1 (BIFUNCTIONAL PROTEIN FOLD)	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	4 / 5	TYR A 84 LYS A 88 GLN A 132 GLY A 291	L34 A 402 (-3.4A) L34 A 402 (-2.8A) L34 A 402 (-3.4A) None	1.49A	6debB-5tc4A: 41.6	6debB-5tc4A: 15.94

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3BJW_A_SVRA508_2","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","5tc4","BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE\/CYCLOHYDROLASE, MITOCHONDRIAL","Homo sapiens",5,"VAL A 308;GLY A 310;PRO A 314;THR A 316;GLY A 179","None;L34 A 402 (-3.6A);L34 A 402 (-4.5A);NAD A 401 (-3.2A);None","1.21A","3bjwG-5tc4A:undetectable",null],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","5tc4","BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE\/CYCLOHYDROLASE, MITOCHONDRIAL","Homo sapiens",5,"GLN A 132;LEU A 133;PRO A 134;ASP A 155;THR A 176","L34 A 402 (-3.4A);L34 A 402 (-4.1A);None;L34 A 402 (-2.9A);NAD A 401 (-3.2A)","0.80A","6debB-5tc4A:41.6","3bjwG-5tc4A:16.56"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","5tc4","BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE\/CYCLOHYDROLASE, MITOCHONDRIAL","Homo sapiens",10,"LEU A 130;GLN A 132;LEU A 133;PRO A 134;ASP A 155;PHE A 157;THR A 176;SER A 202;VAL A 205;THR A 316","L34 A 402 ( 4.7A);L34 A 402 (-3.4A);L34 A 402 (-4.1A);None;L34 A 402 (-2.9A);L34 A 402 (-4.9A);NAD A 401 (-3.2A);NAD A 401 (-2.4A);NAD A 401 (-4.1A);NAD A 401 (-3.2A)","0.63A","6debB-5tc4A:41.6","6debB-5tc4A:15.94"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","5tc4","BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE\/CYCLOHYDROLASE, MITOCHONDRIAL","Homo sapiens",5,"LEU A 130;LEU A 133;PRO A 134;ASP A 155;THR A 316","L34 A 402 ( 4.7A);L34 A 402 (-4.1A);None;L34 A 402 (-2.9A);NAD A 401 (-3.2A)","0.97A","6debB-5tc4A:41.6","6debB-5tc4A:15.94"],["6DEB_B_MTXB303_1","BIFUNCTIONAL PROTEIN FOLD","5tc4","BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE\/CYCLOHYDROLASE, MITOCHONDRIAL","Homo sapiens",4,"LYS A  88;GLN A 132;GLY A 255;ILE A 276","L34 A 402 (-2.8A);L34 A 402 (-3.4A);NAD A 401 (-3.2A);NAD A 401 ( 3.2A)","0.95A","6debB-5tc4A:41.6","6debB-5tc4A:15.94"],["6DEB_B_MTXB303_1","BIFUNCTIONAL PROTEIN FOLD","5tc4","BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE\/CYCLOHYDROLASE, MITOCHONDRIAL","Homo sapiens",4,"TYR A  84;LYS A  88;GLN A 132;GLY A 255","L34 A 402 (-3.4A);L34 A 402 (-2.8A);L34 A 402 (-3.4A);NAD A 401 (-3.2A)","0.47A","6debB-5tc4A:41.6","6debB-5tc4A:15.94"],["6DEB_B_MTXB303_1","BIFUNCTIONAL PROTEIN FOLD","5tc4","BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE\/CYCLOHYDROLASE, MITOCHONDRIAL","Homo sapiens",4,"TYR A  84;LYS A  88;GLN A 132;GLY A 291","L34 A 402 (-3.4A);L34 A 402 (-2.8A);L34 A 402 (-3.4A);None","1.49A","6debB-5tc4A:41.6","6debB-5tc4A:15.94"]]