SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L2P'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETB_1_T441128_1 (TRANSTHYRETIN)	3a7k	HALORHODOPSIN (Natronomonas pharaonis)	4 / 6	MET A 133 LEU A 125 ALA A 128 LEU A 164	L2P A 295 (-4.2A) None None None	0.99A	1etb1-3a7kA: undetectable	1etb1-3a7kA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_A_HSMA401_1 (NITROPHORIN 1)	4fbz	DELTARHODOPSIN (Haloterrigena thermotolerans)	4 / 4	ASP A 114 LEU A 94 LEU A 91 LEU A 93	None None L2P A 304 ( 4.9A) None	1.28A	1u18A-4fbzA: undetectable	1u18A-4fbzA: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GTQ_A_ACTA205_0 (N-ACETYLTRANSFERASE)	2z55	ARCHAERHODOPSIN-2 (Halobacterium sp. AUS-2)	4 / 4	ALA A 60 ALA A 63 ALA A 86 ALA A 89	L2P A 280 ( 4.8A) L2P A 280 ( 4.1A) L2P A 280 ( 4.8A) L2P A 280 (-3.5A)	0.51A	6gtqA-2z55A: undetectable 6gtqB-2z55A: undetectable	6gtqA-2z55A: 23.19 6gtqB-2z55A: 23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GTQ_A_ACTA205_0 (N-ACETYLTRANSFERASE)	2z55	ARCHAERHODOPSIN-2 (Halobacterium sp. AUS-2)	4 / 4	ALA A 86 ALA A 89 ALA A 60 ALA A 63	L2P A 280 ( 4.8A) L2P A 280 (-3.5A) L2P A 280 ( 4.8A) L2P A 280 ( 4.1A)	0.50A	6gtqA-2z55A: undetectable 6gtqB-2z55A: undetectable	6gtqA-2z55A: 23.19 6gtqB-2z55A: 23.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ETB_1_T441128_1","TRANSTHYRETIN","3a7k","HALORHODOPSIN","Natronomonas pharaonis",4,"MET A 133;LEU A 125;ALA A 128;LEU A 164","L2P A 295 (-4.2A);None;None;None","0.99A","1etb1-3a7kA:undetectable",null],["1U18_A_HSMA401_1","NITROPHORIN 1","4fbz","DELTARHODOPSIN","Haloterrigena thermotolerans",4,"ASP A 114;LEU A  94;LEU A  91;LEU A  93","None;None;L2P A 304 ( 4.9A);None","1.28A","1u18A-4fbzA:undetectable","1etb1-3a7kA:19.86"],["6GTQ_A_ACTA205_0","N-ACETYLTRANSFERASE","2z55","ARCHAERHODOPSIN-2","Halobacterium sp. AUS-2",4,"ALA A  60;ALA A  63;ALA A  86;ALA A  89","L2P A 280 ( 4.8A);L2P A 280 ( 4.1A);L2P A 280 ( 4.8A);L2P A 280 (-3.5A)","0.51A","6gtqA-2z55A:undetectable;6gtqB-2z55A:undetectable","1u18A-4fbzA:19.34"],["6GTQ_A_ACTA205_0","N-ACETYLTRANSFERASE","2z55","ARCHAERHODOPSIN-2","Halobacterium sp. AUS-2",4,"ALA A  86;ALA A  89;ALA A  60;ALA A  63","L2P A 280 ( 4.8A);L2P A 280 (-3.5A);L2P A 280 ( 4.8A);L2P A 280 ( 4.1A)","0.50A","6gtqA-2z55A:undetectable;6gtqB-2z55A:undetectable","6gtqA-2z55A:23.19;6gtqB-2z55A:23.19"]]