SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'L04'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.43A 1os2A-1hfsA:
29.2		 1os2A-1hfsA:
58.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.20A 1os2D-1hfsA:
29.2		 1os2D-1hfsA:
58.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 1uttA-1hfsA:
29.6		 1uttA-1hfsA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.23A 1utzA-1hfsA:
29.5		 1utzA-1hfsA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 1utzB-1hfsA:
29.7		 1utzB-1hfsA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 6 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.51A 1y93A-1hfsA:
29.2		 1y93A-1hfsA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.19A 2hu6A-1hfsA:
29.8		 2hu6A-1hfsA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 9 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 2jihA-1hfsA:
10.4		 2jihA-1hfsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 8 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 2jihB-1hfsA:
10.6		 2jihB-1hfsA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 6 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.64A 2ow9A-1hfsA:
29.0		 2ow9A-1hfsA:
60.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.28A 2ow9B-1hfsA:
29.1		 2ow9B-1hfsA:
60.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.31A 2ozrC-1hfsA:
29.4		 2ozrC-1hfsA:
60.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.34A 2ozrD-1hfsA:
29.6		 2ozrD-1hfsA:
60.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.37A 2ozrE-1hfsA:
28.6		 2ozrE-1hfsA:
60.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		3 / 3 HIS A 166
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
 0.41A 3ba0A-1hfsA:
26.7		 3ba0A-1hfsA:
59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 9 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.40A 3hy7A-1hfsA:
10.7		 3hy7A-1hfsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 9 LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.35A 3hy7B-1hfsA:
10.6		 3hy7B-1hfsA:
23.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.27A 3kecA-1hfsA:
29.0		 3kecA-1hfsA:
61.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		3 / 3 HIS A 201
GLU A 202
HIS A 205
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
 0.22A 3kecB-1hfsA:
28.9		 3kecB-1hfsA:
61.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.59A 3likA-1hfsA:
29.5		 3likA-1hfsA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 3lilA-1hfsA:
29.9		 3lilA-1hfsA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 3ljgA-1hfsA:
30.0		 3ljgA-1hfsA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.55A 3lkaA-1hfsA:
29.7		 3lkaA-1hfsA:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		5 / 6 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.63A 4a7bA-1hfsA:
28.8		 4a7bA-1hfsA:
61.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
 0.26A 4a7bB-1hfsA:
28.9		 4a7bB-1hfsA:
61.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 5 GLN A 243
THR A 128
LEU A 218
LEU A 234
 None
None
L04  A 256 ( 4.7A)
None
 1.00A 4lvcB-1hfsA:
undetectable		 4lvcB-1hfsA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 GLN A 243
THR A 128
LEU A 218
LEU A 234
 None
None
L04  A 256 ( 4.7A)
None
 0.99A 5m5kB-1hfsA:
2.5		 5m5kB-1hfsA:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 4 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.21A 5n5jA-1hfsA:
30.0		 5n5jA-1hfsA:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hfs STROMELYSIN-1
(Homo
sapiens) 		4 / 5 HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.22A 5n5kA-1hfsA:
29.6		 5n5kA-1hfsA:
58.12