SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KYD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 299
LEU A 276
ILE A 345
PRO A 346
PHE A 312
 None
None
KYD  A1386 ( 4.2A)
None
None
 1.05A 2ygqA-5fpnA:
undetectable		 2ygqA-5fpnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 340
GLY A 341
GLY A 232
ASP A 234
ARG A 274
 None
KYD  A1386 (-3.7A)
None
None
None
 0.95A 3huoB-5fpnA:
undetectable		 3huoB-5fpnA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		7 / 10 GLY A 203
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 1.02A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 340
SER A 342
ILE A 345
 None
None
None
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 0.94A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.93A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 204
GLY A 232
LYS A 273
ARG A 274
SER A 277
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
None
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.2A)
 0.77A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 0.50A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
SER A 342
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 1.25A 5aqfA-5fpnA:
59.0		 5aqfA-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 1.05A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.91A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 204
GLY A 232
LYS A 273
ARG A 274
SER A 277
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
None
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.2A)
 0.76A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 0.50A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
SER A 342
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 1.25A 5aqfC-5fpnA:
58.8		 5aqfC-5fpnA:
66.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 203
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 1.05A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 231
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.98A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 204
GLY A 232
GLY A 341
SER A 342
ILE A 348
 None
None
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
None
 0.93A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 204
GLY A 232
LYS A 273
ARG A 274
SER A 277
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
None
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.2A)
 0.78A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		8 / 10 GLY A 204
GLY A 232
LYS A 273
SER A 277
GLY A 341
SER A 342
ARG A 344
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 (-3.7A)
KYD  A1386 ( 4.3A)
KYD  A1386 (-4.3A)
KYD  A1386 ( 4.2A)
 0.50A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		6 / 10 GLY A 231
GLY A 232
LYS A 273
SER A 277
SER A 342
ILE A 345
 None
None
KYD  A1386 ( 3.8A)
KYD  A1386 (-1.9A)
KYD  A1386 ( 4.3A)
KYD  A1386 ( 4.2A)
 1.28A 5aqyA-5fpnA:
60.3		 5aqyA-5fpnA:
53.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 341
GLY A 340
PHE A 312
ILE A 348
PHE A 235
 KYD  A1386 (-3.7A)
None
None
None
None
 1.50A 5lbtA-5fpnA:
undetectable
5lbtB-5fpnA:
undetectable		 5lbtA-5fpnA:
16.17
5lbtB-5fpnA:
16.17