SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KSA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
VAL A 104
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.50A 1fmoE-4wsqA:
26.0		 1fmoE-4wsqA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.93A 1iepA-4wsqA:
22.6		 1iepA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.69A 1iepA-4wsqA:
22.6		 1iepA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.79A 1iepA-4wsqA:
22.6		 1iepA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
ZN  A 403 ( 2.6A)
 1.02A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.77A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
PHE A 128
GLY A 131
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
None
 0.71A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 VAL A 104
ILE A 124
ARG A 175
LEU A 183
 None
None
None
KSA  A 405 (-4.6A)
 0.74A 1iepB-4wsqA:
22.6		 1iepB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
PHE A 128
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.57A 1opjA-4wsqA:
22.3		 1opjA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
VAL A 104
PHE A 128
GLY A 132
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
ZN  A 403 ( 2.6A)
 0.97A 1opjB-4wsqA:
22.0		 1opjB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
VAL A 104
PHE A 128
GLY A 132
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.88A 1opjB-4wsqA:
22.0		 1opjB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  60
ALA A  72
MET A  94
VAL A 104
PHE A 128
GLY A 131
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
None
 0.77A 1opjB-4wsqA:
22.0		 1opjB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  60
ALA A  72
GLU A  90
CYH A 129
LEU A 165
HIS A 174
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
None
None
 0.82A 1uwjA-4wsqA:
5.5		 1uwjA-4wsqA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  60
ALA A  72
GLU A  90
CYH A 129
LEU A 165
HIS A 174
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
None
None
 0.82A 1uwjB-4wsqA:
23.2		 1uwjB-4wsqA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  52
VAL A  60
ALA A  72
MET A 126
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.52A 1xbbA-4wsqA:
25.4		 1xbbA-4wsqA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
MET A 126
LYS A 178
ASN A 181
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
ZN  A 403 ( 4.3A)
KSA  A 405 (-4.0A)
ZN  A 403 ( 2.6A)
 0.87A 2fumB-4wsqA:
26.9		 2fumB-4wsqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
GLY A  55
VAL A  60
ALA A  72
MET A 126
LYS A 178
ASN A 181
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
ZN  A 403 ( 4.3A)
KSA  A 405 (-4.0A)
 0.93A 2fumD-4wsqA:
18.2		 2fumD-4wsqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
ALA A  72
LYS A  74
MET A  94
VAL A 104
ILE A 124
PHE A 128
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.89A 2gqgA-4wsqA:
25.0		 2gqgA-4wsqA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
ALA A  72
MET A  94
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.80A 2gqgA-4wsqA:
25.0		 2gqgA-4wsqA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
MET A  94
VAL A 104
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.66A 2gqgB-4wsqA:
25.1		 2gqgB-4wsqA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.93A 2hyyA-4wsqA:
22.9		 2hyyA-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.75A 2hyyA-4wsqA:
22.9		 2hyyA-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.72A 2hyyB-4wsqA:
22.9		 2hyyB-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.58A 2hyyB-4wsqA:
23.0		 2hyyB-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
VAL A 104
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.96A 2hyyC-4wsqA:
23.0		 2hyyC-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
VAL A 104
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.62A 2hyyC-4wsqA:
23.0		 2hyyC-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
LYS A  74
MET A  94
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.67A 2hyyC-4wsqA:
23.0		 2hyyC-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
ILE A 124
PHE A 128
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.96A 2hyyD-4wsqA:
22.5		 2hyyD-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
ILE A 124
PHE A 128
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.76A 2hyyD-4wsqA:
22.5		 2hyyD-4wsqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.83A 2oiqA-4wsqA:
22.6		 2oiqA-4wsqA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
 KSA  A 405 (-3.2A)
None
None
None
None
None
KSA  A 405 (-4.6A)
 0.86A 2pl0A-4wsqA:
21.7		 2pl0A-4wsqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  52
VAL A  60
ALA A  72
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.79A 2xp2A-4wsqA:
23.5		 2xp2A-4wsqA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
ALA A  72
VAL A 104
PHE A 128
CYH A 129
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.56A 3c7qA-4wsqA:
21.8		 3c7qA-4wsqA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 10 LEU A  52
VAL A  60
LYS A  74
VAL A 104
ILE A 124
PHE A 128
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.8A)
 0.70A 3cs9A-4wsqA:
22.6		 3cs9A-4wsqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  52
VAL A  60
LYS A  74
VAL A 104
ILE A 124
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.6A)
 0.71A 3cs9B-4wsqA:
22.7		 3cs9B-4wsqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
HIS A 174
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
None
ZN  A 403 ( 2.6A)
 1.19A 3cs9C-4wsqA:
22.0		 3cs9C-4wsqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  52
VAL A  60
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
None
 0.73A 3cs9C-4wsqA:
22.1		 3cs9C-4wsqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  72
MET A  94
PHE A 128
GLY A 132
HIS A 174
 KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
None
 0.56A 3cs9D-4wsqA:
21.9		 3cs9D-4wsqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
VAL A  60
LYS A  74
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
KSA  A 405 (-4.6A)
 0.85A 3cs9D-4wsqA:
21.9		 3cs9D-4wsqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 11 LEU A  52
VAL A  60
ALA A  72
VAL A 104
CYH A 129
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.58A 3g0eA-4wsqA:
21.3		 3g0eA-4wsqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 11 LEU A  52
VAL A  60
ALA A  72
CYH A 129
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.63A 3g0fA-4wsqA:
22.2		 3g0fA-4wsqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 10 LEU A  52
VAL A  60
ALA A  72
CYH A 129
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.54A 3g0fB-4wsqA:
22.6		 3g0fB-4wsqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.59A 3g5dA-4wsqA:
24.1		 3g5dA-4wsqA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
VAL A 104
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
 0.71A 3gvuA-4wsqA:
22.8		 3gvuA-4wsqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.95A 3k5vA-4wsqA:
22.2		 3k5vA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.80A 3k5vA-4wsqA:
22.2		 3k5vA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.68A 3k5vA-4wsqA:
22.2		 3k5vA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.93A 3k5vB-4wsqA:
22.1		 3k5vB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.77A 3k5vB-4wsqA:
22.1		 3k5vB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.0A)
None
None
None
 0.66A 3k5vB-4wsqA:
22.1		 3k5vB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.96A 3ms9A-4wsqA:
22.3		 3ms9A-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.79A 3ms9A-4wsqA:
22.3		 3ms9A-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.91A 3ms9B-4wsqA:
22.3		 3ms9B-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.76A 3ms9B-4wsqA:
22.3		 3ms9B-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.95A 3mssA-4wsqA:
22.5		 3mssA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.81A 3mssA-4wsqA:
22.5		 3mssA-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.68A 3mssB-4wsqA:
22.5		 3mssB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.75A 3mssB-4wsqA:
22.5		 3mssB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.96A 3mssC-4wsqA:
22.5		 3mssC-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
PHE A 128
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.80A 3mssC-4wsqA:
22.5		 3mssC-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.90A 3mssD-4wsqA:
22.4		 3mssD-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.75A 3mssD-4wsqA:
22.4		 3mssD-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 VAL A  60
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.9A)
None
None
None
 0.66A 3mssD-4wsqA:
22.4		 3mssD-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.61A 3octA-4wsqA:
23.3		 3octA-4wsqA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
GLU A  90
MET A  94
VAL A 104
GLY A 132
HIS A 174
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
None
 0.79A 3oxzA-4wsqA:
22.7		 3oxzA-4wsqA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.6A)
 0.48A 3pyyB-4wsqA:
22.4		 3pyyB-4wsqA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  60
ALA A  72
GLU A  90
MET A  94
VAL A 104
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
 0.68A 3pyyB-4wsqA:
22.4		 3pyyB-4wsqA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 ASP A 176
ASP A 194
GLY A 196
GLN A 133
 ZN  A 403 (-3.2A)
ZN  A 403 ( 2.6A)
None
KSA  A 405 (-3.2A)
 1.01A 3s3mA-4wsqA:
undetectable		 3s3mA-4wsqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 ASP A 176
ASP A 194
GLY A 196
GLN A 133
 ZN  A 403 (-3.2A)
ZN  A 403 ( 2.6A)
None
KSA  A 405 (-3.2A)
 1.00A 3s3nA-4wsqA:
undetectable		 3s3nA-4wsqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.60A 3sxrA-4wsqA:
24.8		 3sxrA-4wsqA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
VAL A 104
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.44A 3sxrA-4wsqA:
24.8		 3sxrA-4wsqA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.57A 3sxrB-4wsqA:
24.3		 3sxrB-4wsqA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
ALA A  72
GLU A  90
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.78A 3ue4A-4wsqA:
24.8		 3ue4A-4wsqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
ALA A  72
LYS A  74
GLU A  90
VAL A 104
ILE A 124
PHE A 128
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
 0.91A 3ue4A-4wsqA:
24.8		 3ue4A-4wsqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		10 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
MET A  94
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.72A 3ue4B-4wsqA:
24.4		 3ue4B-4wsqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  52
VAL A  60
ALA A  72
CYH A 129
GLY A 132
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.4A)
 0.53A 3wzdA-4wsqA:
22.4		 3wzdA-4wsqA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 LYS A  74
ILE A  93
VAL A 104
LEU A 183
 None
None
None
KSA  A 405 (-4.6A)
 1.03A 3wzdA-4wsqA:
22.4		 3wzdA-4wsqA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 VAL A 104
CYH A 129
LEU A 183
CYH A 193
ASP A 194
 None
KSA  A 405 (-4.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
ZN  A 403 ( 2.6A)
 0.68A 3wzeA-4wsqA:
22.9		 3wzeA-4wsqA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
ALA A  72
GLU A  90
LEU A 165
HIS A 174
ARG A 175
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
 0.84A 3zosA-4wsqA:
21.8		 3zosA-4wsqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
VAL A 104
PHE A 128
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.65A 4ag8A-4wsqA:
23.0		 4ag8A-4wsqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
VAL A 104
PHE A 128
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.40A 4ag8A-4wsqA:
23.0		 4ag8A-4wsqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  52
VAL A  60
ALA A  72
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.36A 4agcA-4wsqA:
22.5		 4agcA-4wsqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 11 LEU A  52
ALA A  72
VAL A 104
PHE A 128
CYH A 129
GLY A 132
LEU A 183
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.49A 4agdA-4wsqA:
22.1		 4agdA-4wsqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 124
MET A 126
ASP A 176
LYS A 178
ASN A 181
 None
KSA  A 405 ( 3.7A)
ZN  A 403 (-3.2A)
ZN  A 403 ( 4.3A)
KSA  A 405 (-4.0A)
 0.70A 4an2A-4wsqA:
23.2		 4an2A-4wsqA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 9 LEU A  52
VAL A  60
ALA A  72
MET A 126
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.87A 4ansA-4wsqA:
23.4		 4ansA-4wsqA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
GLU A  90
PHE A 128
GLY A 132
LEU A 165
HIS A 174
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
None
None
 0.80A 4asdA-4wsqA:
22.6		 4asdA-4wsqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 VAL A 104
CYH A 129
LEU A 183
CYH A 193
 None
KSA  A 405 (-4.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.51A 4asdA-4wsqA:
22.6		 4asdA-4wsqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
GLU A  90
ILE A  93
MET A  94
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.98A 4bkjB-4wsqA:
22.0		 4bkjB-4wsqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  60
ALA A  72
GLU A  90
ILE A  93
MET A  94
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
 0.94A 4bkjB-4wsqA:
22.0		 4bkjB-4wsqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
GLU A  90
ILE A  93
MET A  94
VAL A 104
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
 0.85A 4csvA-4wsqA:
22.9		 4csvA-4wsqA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 10 ALA A  72
VAL A 104
MET A 126
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 (-3.2A)
None
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.40A 4ks8A-4wsqA:
26.1		 4ks8A-4wsqA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
None
ZN  A 403 ( 2.6A)
 1.05A 4mxoA-4wsqA:
23.9		 4mxoA-4wsqA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
VAL A 104
ILE A 124
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.82A 4mxyA-4wsqA:
12.4		 4mxyA-4wsqA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
VAL A 104
ILE A 124
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.82A 4mxzA-4wsqA:
12.4		 4mxzA-4wsqA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 7 ALA A  72
CYH A 129
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.44A 4ogrE-4wsqA:
24.0		 4ogrE-4wsqA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 VAL A  60
ALA A  72
CYH A 129
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.57A 4ogrI-4wsqA:
24.7		 4ogrI-4wsqA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  72
GLU A  90
MET A  94
LEU A 165
ARG A 175
 KSA  A 405 (-3.2A)
None
None
None
None
 0.82A 4qrcA-4wsqA:
22.9		 4qrcA-4wsqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
PHE A 128
GLY A 132
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.74A 4twpA-4wsqA:
24.9		 4twpA-4wsqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
PHE A 128
GLY A 132
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.72A 4twpB-4wsqA:
24.9		 4twpB-4wsqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
VAL A  60
LYS A  74
ILE A 103
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
 0.59A 4tyjA-4wsqA:
22.5		 4tyjA-4wsqA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
VAL A  60
LYS A  74
ILE A 103
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
 0.68A 4tyjA-4wsqA:
22.5		 4tyjA-4wsqA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  72
CYH A 129
GLY A 132
HIS A 174
LEU A 183
CYH A 193
 KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
None
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.54A 4u0iA-4wsqA:
22.6		 4u0iA-4wsqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 11 LEU A  52
GLY A  55
VAL A  60
ALA A  72
GLY A 132
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.71A 4u5jA-4wsqA:
25.5		 4u5jA-4wsqA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  72
GLU A  90
MET A  94
LEU A 165
HIS A 174
 KSA  A 405 (-3.2A)
None
None
None
None
 0.85A 4v01A-4wsqA:
21.7		 4v01A-4wsqA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  72
GLU A  90
MET A  94
LEU A 165
HIS A 174
 KSA  A 405 (-3.2A)
None
None
None
None
 0.81A 4v01B-4wsqA:
22.2		 4v01B-4wsqA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  60
ALA A  72
LYS A  74
PHE A 128
GLY A 132
ASN A 181
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
 0.78A 4wa9B-4wsqA:
24.0		 4wa9B-4wsqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 LEU A  52
ALA A  72
MET A 126
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.6A)
 0.40A 4wboB-4wsqA:
24.3		 4wboB-4wsqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  52
ALA A  72
MET A 126
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.6A)
 0.44A 4wboC-4wsqA:
24.5		 4wboC-4wsqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.56A 4xeyA-4wsqA:
24.5		 4xeyA-4wsqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
MET A  94
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.58A 4xeyB-4wsqA:
24.1		 4xeyB-4wsqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  52
VAL A  60
ALA A  72
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.77A 5aaaA-4wsqA:
23.9		 5aaaA-4wsqA:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
ALA A  72
PHE A 128
CYH A 129
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.8A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.56A 5ajqA-4wsqA:
23.1		 5ajqA-4wsqA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A  52
ALA A  72
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.60A 5h2uC-4wsqA:
23.6		 5h2uC-4wsqA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  52
VAL A  60
ALA A  72
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.56A 5h2uD-4wsqA:
23.8		 5h2uD-4wsqA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  60
ALA A  72
ILE A 124
CYH A 193
PHE A 195
GLY A 196
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-3.4A)
None
None
 1.11A 5hesA-4wsqA:
7.1		 5hesA-4wsqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 10 LEU A  52
VAL A  60
LYS A  74
ILE A 124
PHE A 128
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.69A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 10 VAL A  60
LYS A  74
GLU A  90
ILE A 124
PHE A 128
GLY A 132
 KSA  A 405 ( 4.9A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.82A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  72
MET A  94
VAL A 104
HIS A 174
LEU A 183
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
 0.71A 5mo4A-4wsqA:
19.0		 5mo4A-4wsqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 10 LEU A  52
VAL A  60
ALA A  72
VAL A 104
MET A 126
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.6A)
 0.41A 5n3hA-4wsqA:
26.0		 5n3hA-4wsqA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 ALA A  72
CYH A 129
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.42A 5owrA-4wsqA:
21.1		 5owrA-4wsqA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 ALA A  72
GLU A  90
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.61A 5owrA-4wsqA:
21.1		 5owrA-4wsqA:
29.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		10 / 12 GLU A  50
ALA A  53
LEU A  62
ALA A  72
GLU A  90
MET A  94
VAL A 104
PHE A 128
GLY A 132
LEU A 183
 None
KSA  A 405 (-3.3A)
None
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.76A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 GLU A  50
ALA A  53
LEU A  62
ALA A  72
MET A  94
VAL A 104
PHE A 128
GLY A 131
 None
KSA  A 405 (-3.3A)
None
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
None
 0.88A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 GLU A  50
LEU A  62
ALA A  72
MET A  94
VAL A 104
PHE A 128
GLY A 132
GLN A 133
LEU A 183
 None
None
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
 0.67A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 5 LEU A  52
VAL A  60
MET A 126
CYH A 129
CYH A 193
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.4A)
 0.57A 5te0A-4wsqA:
47.3		 5te0A-4wsqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 4 VAL A  60
LYS A  74
VAL A 104
ASN A 181
 KSA  A 405 ( 4.9A)
None
None
KSA  A 405 (-4.0A)
 0.68A 5vc3A-4wsqA:
25.3		 5vc3A-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  52
ALA A  72
LYS A  74
GLU A  90
VAL A 104
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
 0.94A 5vcvA-4wsqA:
25.8		 5vcvA-4wsqA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 131
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
None
 0.80A 5vcyA-4wsqA:
26.2		 5vcyA-4wsqA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  52
ALA A  72
VAL A 104
MET A 126
CYH A 129
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
 0.59A 5w5vA-4wsqA:
14.0		 5w5vA-4wsqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 132
GLN A 133
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
 0.58A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 132
GLN A 133
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
 0.58A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.59A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.59A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
CYH A 193
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
ZN  A 403 ( 2.6A)
 0.65A 5y7zB-4wsqA:
33.9		 5y7zB-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 132
GLN A 133
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.81A 5y80A-4wsqA:
32.5		 5y80A-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.67A 5y80A-4wsqA:
32.5		 5y80A-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
 0.92A 5zv2B-4wsqA:
22.1		 5zv2B-4wsqA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 1.02A 6hd4A-4wsqA:
22.1		 6hd4A-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
None
KSA  A 405 (-4.6A)
 0.78A 6hd4A-4wsqA:
22.1		 6hd4A-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 1.00A 6hd4B-4wsqA:
22.0		 6hd4B-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
None
KSA  A 405 (-4.6A)
 0.74A 6hd4B-4wsqA:
22.0		 6hd4B-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ALA A  72
GLU A  90
MET A  94
VAL A 104
ILE A 124
PHE A 128
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.94A 6hd6A-4wsqA:
22.1		 6hd6A-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
PHE A 128
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.81A 6hd6A-4wsqA:
22.1		 6hd6A-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A  72
GLU A  90
MET A  94
VAL A 104
PHE A 128
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.96A 6hd6B-4wsqA:
22.0		 6hd6B-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
PHE A 128
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.85A 6hd6B-4wsqA:
22.0		 6hd6B-4wsqA:
14.33