SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KRS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K87_A_ADNA602_1 (PROLINE--TRNA LIGASE)	6aqh	LYSINE--TRNA LIGASE (Mycolicibacteriu m thermoresistibil e)	4 / 8	ARG A 258 PHE A 270 THR A 422 ARG A 478	LYS A 601 ( 3.4A) KRS A 602 (-3.5A) LYS A 601 ( 4.3A) KRS A 602 (-3.5A)	0.75A	4k87A-6aqhA: 11.3	4k87A-6aqhA: 24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_A_ADNA602_1 (LYSINE--TRNA LIGASE)	5hgq	LYSINE--TRNA LIGASE (Loa loa)	7 / 10	ARG A 255 GLU A 257 HIS A 263 PHE A 267 GLU A 427 GLY A 483 ARG A 486	LYS A 601 (-3.4A) KRS A 602 (-3.1A) KRS A 602 (-4.4A) KRS A 602 (-3.6A) KRS A 602 (-4.3A) KRS A 602 (-3.5A) KRS A 602 (-3.2A)	0.80A	6bniA-5hgqA: 43.9	6bniA-5hgqA: 8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_A_ADNA602_1 (LYSINE--TRNA LIGASE)	5hgq	LYSINE--TRNA LIGASE (Loa loa)	7 / 10	ARG A 255 HIS A 263 PHE A 267 GLU A 427 GLY A 483 ARG A 486 ILE A 497	LYS A 601 (-3.4A) KRS A 602 (-4.4A) KRS A 602 (-3.6A) KRS A 602 (-4.3A) KRS A 602 (-3.5A) KRS A 602 (-3.2A) None	0.38A	6bniA-5hgqA: 43.9	6bniA-5hgqA: 8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_A_ADNA602_1 (LYSINE--TRNA LIGASE)	6aqh	LYSINE--TRNA LIGASE (Mycolicibacteriu m thermoresistibil e)	7 / 10	ARG A 258 HIS A 266 PHE A 270 GLU A 419 GLY A 475 ARG A 478 ILE A 488	LYS A 601 ( 3.4A) KRS A 602 (-4.5A) KRS A 602 (-3.5A) KRS A 602 (-3.8A) KRS A 602 (-3.8A) KRS A 602 (-3.5A) None	0.53A	6bniA-6aqhA: 43.9	6bniA-6aqhA: 10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_B_ADNB602_1 (LYSINE--TRNA LIGASE)	5hgq	LYSINE--TRNA LIGASE (Loa loa)	8 / 10	ARG A 255 GLU A 257 HIS A 263 PHE A 267 GLU A 427 GLY A 483 ARG A 486 ILE A 497	LYS A 601 (-3.4A) KRS A 602 (-3.1A) KRS A 602 (-4.4A) KRS A 602 (-3.6A) KRS A 602 (-4.3A) KRS A 602 (-3.5A) KRS A 602 (-3.2A) None	0.72A	6bniB-5hgqA: 44.1	6bniB-5hgqA: 8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_B_ADNB602_1 (LYSINE--TRNA LIGASE)	6aqh	LYSINE--TRNA LIGASE (Mycolicibacteriu m thermoresistibil e)	7 / 10	ARG A 258 HIS A 266 PHE A 270 GLU A 419 GLY A 475 ARG A 478 ILE A 488	LYS A 601 ( 3.4A) KRS A 602 (-4.5A) KRS A 602 (-3.5A) KRS A 602 (-3.8A) KRS A 602 (-3.8A) KRS A 602 (-3.5A) None	0.53A	6bniB-6aqhA: 44.0	6bniB-6aqhA: 10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	6aqh	LYSINE--TRNA LIGASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	ASP A 412 VAL A 387 GLU A 419 ALA A 213	None None KRS A 602 (-3.8A) LYS A 601 (-3.4A)	1.18A	6djzB-6aqhA: undetectable	6djzB-6aqhA: 19.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4K87_A_ADNA602_1","PROLINE--TRNA LIGASE","6aqh","LYSINE--TRNA LIGASE","Mycolicibacterium thermoresistibile",4,"ARG A 258;PHE A 270;THR A 422;ARG A 478","LYS A 601 ( 3.4A);KRS A 602 (-3.5A);LYS A 601 ( 4.3A);KRS A 602 (-3.5A)","0.75A","4k87A-6aqhA:11.3",null],["6BNI_A_ADNA602_1","LYSINE--TRNA LIGASE","5hgq","LYSINE--TRNA LIGASE","Loa loa",7,"ARG A 255;GLU A 257;HIS A 263;PHE A 267;GLU A 427;GLY A 483;ARG A 486","LYS A 601 (-3.4A);KRS A 602 (-3.1A);KRS A 602 (-4.4A);KRS A 602 (-3.6A);KRS A 602 (-4.3A);KRS A 602 (-3.5A);KRS A 602 (-3.2A)","0.80A","6bniA-5hgqA:43.9","4k87A-6aqhA:24.21"],["6BNI_A_ADNA602_1","LYSINE--TRNA LIGASE","5hgq","LYSINE--TRNA LIGASE","Loa loa",7,"ARG A 255;HIS A 263;PHE A 267;GLU A 427;GLY A 483;ARG A 486;ILE A 497","LYS A 601 (-3.4A);KRS A 602 (-4.4A);KRS A 602 (-3.6A);KRS A 602 (-4.3A);KRS A 602 (-3.5A);KRS A 602 (-3.2A);None","0.38A","6bniA-5hgqA:43.9","6bniA-5hgqA:8.75"],["6BNI_A_ADNA602_1","LYSINE--TRNA LIGASE","6aqh","LYSINE--TRNA LIGASE","Mycolicibacterium thermoresistibile",7,"ARG A 258;HIS A 266;PHE A 270;GLU A 419;GLY A 475;ARG A 478;ILE A 488","LYS A 601 ( 3.4A);KRS A 602 (-4.5A);KRS A 602 (-3.5A);KRS A 602 (-3.8A);KRS A 602 (-3.8A);KRS A 602 (-3.5A);None","0.53A","6bniA-6aqhA:43.9","6bniA-5hgqA:8.75"],["6BNI_B_ADNB602_1","LYSINE--TRNA LIGASE","5hgq","LYSINE--TRNA LIGASE","Loa loa",8,"ARG A 255;GLU A 257;HIS A 263;PHE A 267;GLU A 427;GLY A 483;ARG A 486;ILE A 497","LYS A 601 (-3.4A);KRS A 602 (-3.1A);KRS A 602 (-4.4A);KRS A 602 (-3.6A);KRS A 602 (-4.3A);KRS A 602 (-3.5A);KRS A 602 (-3.2A);None","0.72A","6bniB-5hgqA:44.1","6bniA-6aqhA:10.82"],["6BNI_B_ADNB602_1","LYSINE--TRNA LIGASE","6aqh","LYSINE--TRNA LIGASE","Mycolicibacterium thermoresistibile",7,"ARG A 258;HIS A 266;PHE A 270;GLU A 419;GLY A 475;ARG A 478;ILE A 488","LYS A 601 ( 3.4A);KRS A 602 (-4.5A);KRS A 602 (-3.5A);KRS A 602 (-3.8A);KRS A 602 (-3.8A);KRS A 602 (-3.5A);None","0.53A","6bniB-6aqhA:44.0","6bniB-5hgqA:8.75"],["6DJZ_B_GMJB301_1","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","6aqh","LYSINE--TRNA LIGASE","Mycolicibacterium thermoresistibile",4,"ASP A 412;VAL A 387;GLU A 419;ALA A 213","None;None;KRS A 602 (-3.8A);LYS A 601 (-3.4A)","1.18A","6djzB-6aqhA:undetectable","6bniB-6aqhA:10.82"]]