SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KPR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	11GS_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE)	5lnt	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1 (Arabidopsis thaliana)	4 / 7	PHE A 250 GLY A 230 ARG A 166 GLY A 252	KPR A 401 (-4.2A) KPR A 401 (-3.4A) None KPR A 401 (-3.4A)	0.84A	11gsB-5lntA: undetectable	11gsB-5lntA: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UXP_B_CLMB1211_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR)	5lnt	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1 (Arabidopsis thaliana)	5 / 11	HIS A 180 ALA A 229 CYH A 146 GLY A 145 ILE A 163	None KPR A 401 (-3.2A) None None None	1.18A	2uxpB-5lntA: undetectable	2uxpB-5lntA: 21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA2)	5lnt	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1 (Arabidopsis thaliana)	4 / 6	SER A 121 ARG A 164 GLY A 231 GLY A 170	KPR A 401 (-3.2A) KPR A 401 (-4.0A) KPR A 401 (-3.6A) KPR A 401 (-3.9A)	0.88A	4koeA-5lntA: undetectable 4koeB-5lntA: undetectable 4koeC-5lntA: undetectable	4koeA-5lntA: 22.76 4koeB-5lntA: 22.76 4koeC-5lntA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA4)	5lnt	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1 (Arabidopsis thaliana)	4 / 7	ARG A 164 SER A 121 GLY A 231 GLY A 170	KPR A 401 (-4.0A) KPR A 401 (-3.2A) KPR A 401 (-3.6A) KPR A 401 (-3.9A)	0.85A	4koeA-5lntA: undetectable 4koeB-5lntA: undetectable 4koeD-5lntA: undetectable	4koeA-5lntA: 22.76 4koeB-5lntA: 22.76 4koeD-5lntA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	5lnt	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1 (Arabidopsis thaliana)	4 / 6	GLY A 231 GLY A 170 SER A 121 ARG A 164	KPR A 401 (-3.6A) KPR A 401 (-3.9A) KPR A 401 (-3.2A) KPR A 401 (-4.0A)	0.85A	4z53A-5lntA: undetectable 4z53B-5lntA: undetectable	4z53A-5lntA: 20.00 4z53B-5lntA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	5lnt	PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1 (Arabidopsis thaliana)	4 / 7	ARG A 164 GLY A 231 GLY A 170 SER A 121	KPR A 401 (-4.0A) KPR A 401 (-3.6A) KPR A 401 (-3.9A) KPR A 401 (-3.2A)	0.82A	4z53A-5lntA: undetectable 4z53B-5lntA: undetectable	4z53A-5lntA: 20.00 4z53B-5lntA: 20.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["11GS_B_EAAB211_1","GLUTATHIONE S-TRANSFERASE","5lnt","PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1","Arabidopsis thaliana",4,"PHE A 250;GLY A 230;ARG A 166;GLY A 252","KPR A 401 (-4.2A);KPR A 401 (-3.4A);None;KPR A 401 (-3.4A)","0.84A","11gsB-5lntA:undetectable",null],["2UXP_B_CLMB1211_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR","5lnt","PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1","Arabidopsis thaliana",5,"HIS A 180;ALA A 229;CYH A 146;GLY A 145;ILE A 163","None;KPR A 401 (-3.2A);None;None;None","1.18A","2uxpB-5lntA:undetectable","11gsB-5lntA:23.40"],["4KOE_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA2","5lnt","PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1","Arabidopsis thaliana",4,"SER A 121;ARG A 164;GLY A 231;GLY A 170","KPR A 401 (-3.2A);KPR A 401 (-4.0A);KPR A 401 (-3.6A);KPR A 401 (-3.9A)","0.88A","4koeA-5lntA:undetectable;4koeB-5lntA:undetectable;4koeC-5lntA:undetectable","2uxpB-5lntA:21.94"],["4KOE_H_TR6H101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA4","5lnt","PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1","Arabidopsis thaliana",4,"ARG A 164;SER A 121;GLY A 231;GLY A 170","KPR A 401 (-4.0A);KPR A 401 (-3.2A);KPR A 401 (-3.6A);KPR A 401 (-3.9A)","0.85A","4koeA-5lntA:undetectable;4koeB-5lntA:undetectable;4koeD-5lntA:undetectable","4koeA-5lntA:22.76;4koeB-5lntA:22.76;4koeC-5lntA:21.52"],["4Z53_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","5lnt","PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1","Arabidopsis thaliana",4,"GLY A 231;GLY A 170;SER A 121;ARG A 164","KPR A 401 (-3.6A);KPR A 401 (-3.9A);KPR A 401 (-3.2A);KPR A 401 (-4.0A)","0.85A","4z53A-5lntA:undetectable;4z53B-5lntA:undetectable","4koeA-5lntA:22.76;4koeB-5lntA:22.76;4koeD-5lntA:21.52"],["4Z53_H_TR6H101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","5lnt","PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT PDX1.1","Arabidopsis thaliana",4,"ARG A 164;GLY A 231;GLY A 170;SER A 121","KPR A 401 (-4.0A);KPR A 401 (-3.6A);KPR A 401 (-3.9A);KPR A 401 (-3.2A)","0.82A","4z53A-5lntA:undetectable;4z53B-5lntA:undetectable","4z53A-5lntA:20.00;4z53B-5lntA:20.00"]]