SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KPL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 8 LEU A  42
ILE A 212
GLU A 181
VAL A 179
ILE A 200
 KPL  A 265 (-4.9A)
KPL  A 265 ( 4.0A)
KPL  A 265 (-3.0A)
None
None
 1.38A 1linA-1m3uA:
undetectable		 1linA-1m3uA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 11 THR A 140
PRO A 141
THR A  69
ALA A 108
VAL A 103
 None
KPL  A 265 (-4.5A)
None
None
None
 0.96A 1rv7A-1m3uA:
0.0
1rv7B-1m3uA:
0.0		 1rv7A-1m3uA:
17.80
1rv7B-1m3uA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 THR A  21
THR A  23
VAL A 214
GLY A 203
LEU A 177
 None
KPL  A 265 (-4.1A)
KPL  A 265 (-4.7A)
None
None
 1.14A 2cbrA-1m3uA:
undetectable		 2cbrA-1m3uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 7 LEU A 139
THR A 140
PRO A 141
GLY A 135
 None
None
KPL  A 265 (-4.5A)
None
 0.90A 2ddwB-1m3uA:
undetectable		 2ddwB-1m3uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 MET A 215
HIS A 216
GLY A  44
LEU A  81
ASP A  26
 None
None
KPL  A 265 (-3.2A)
None
None
 1.19A 3i5uA-1m3uA:
undetectable		 3i5uA-1m3uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 MET A 215
HIS A 216
GLY A  44
LEU A  81
ASP A  26
 None
None
KPL  A 265 (-3.2A)
None
None
 1.18A 3i5uB-1m3uA:
undetectable		 3i5uB-1m3uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 11 VAL A  43
LEU A  42
VAL A 103
GLY A 107
ALA A 108
 None
KPL  A 265 (-4.9A)
None
None
None
 1.06A 3pghB-1m3uA:
0.0		 3pghB-1m3uA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 6 ILE A 212
GLY A 203
VAL A 183
HIS A 136
 KPL  A 265 ( 4.0A)
None
None
KPL  A 265 (-4.5A)
 1.04A 4oltB-1m3uA:
undetectable		 4oltB-1m3uA:
21.92