SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KPC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE
(Xanthobacter
autotrophicus) 		5 / 9 ALA A 249
TYR A 247
GLY A 186
GLY A 245
ILE A 210
 None
None
KPC  A1252 (-4.7A)
None
None
 1.04A 2v7bA-2cfcA:
4.4		 2v7bA-2cfcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE
(Xanthobacter
autotrophicus) 		5 / 9 ALA A 249
TYR A 247
GLY A 186
GLY A 245
ILE A 210
 None
None
KPC  A1252 (-4.7A)
None
None
 1.02A 2v7bB-2cfcA:
3.4		 2v7bB-2cfcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE
(Xanthobacter
autotrophicus) 		4 / 8 PRO A 185
SER A 142
GLY A 216
MET A 187
 NAD  A1251 (-3.5A)
KPC  A1252 (-3.5A)
None
NAD  A1251 (-3.8A)
 1.09A 3hcrA-2cfcA:
3.4		 3hcrA-2cfcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE
(Xanthobacter
autotrophicus) 		5 / 9 ALA A 249
TYR A 247
GLY A 186
GLY A 245
ILE A 210
 None
None
KPC  A1252 (-4.7A)
None
None
 1.05A 4eatB-2cfcA:
undetectable		 4eatB-2cfcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE
(Xanthobacter
autotrophicus) 		5 / 10 GLY A 186
LEU A 241
ALA A 224
ASP A 223
ALA A 219
 KPC  A1252 (-4.7A)
None
None
None
None
 1.13A 4wnuD-2cfcA:
undetectable		 4wnuD-2cfcA:
20.17