SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KPA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		4 / 4 ASP A 136
ASP A 252
ASP A 108
GLY A 375
 KPA  A 500 (-4.7A)
SO4  A 501 (-4.9A)
None
None
 1.39A 2igtC-1vb3A:
2.2		 2igtC-1vb3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		4 / 7 VAL A 312
ASN A 249
GLY A 248
VAL A 279
 None
KPA  A 500 ( 4.1A)
SO4  A 501 (-3.7A)
None
 0.81A 2y05A-1vb3A:
2.2
2y05B-1vb3A:
2.3		 2y05A-1vb3A:
22.71
2y05B-1vb3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		4 / 8 PHE A 106
THR A 137
ALA A 377
ALA A 105
 None
KPA  A 500 (-2.9A)
None
None
 0.84A 3ax9B-1vb3A:
undetectable		 3ax9B-1vb3A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		4 / 6 SER A 134
GLN A 166
PHE A 382
HIS A 353
 KPA  A 500 (-3.1A)
None
None
None
 1.37A 3lskB-1vb3A:
0.0		 3lskB-1vb3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		4 / 6 SER A 134
GLN A 166
PHE A 382
HIS A 353
 KPA  A 500 (-3.1A)
None
None
None
 1.33A 3lskD-1vb3A:
0.0		 3lskD-1vb3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 106
THR A 137
ALA A 377
ALA A 105
 None
KPA  A 500 (-2.9A)
None
None
 0.85A 3ns1C-1vb3A:
undetectable		 3ns1C-1vb3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		4 / 8 PHE A 106
THR A 137
ALA A 377
ALA A 105
 None
KPA  A 500 (-2.9A)
None
None
 0.85A 3ns1L-1vb3A:
undetectable		 3ns1L-1vb3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		5 / 11 SER A 134
GLY A 135
ALA A 105
ILE A  58
LEU A 262
 KPA  A 500 (-3.1A)
KPA  A 500 ( 4.2A)
None
None
None
 1.00A 4kt0A-1vb3A:
undetectable
4kt0J-1vb3A:
undetectable		 4kt0A-1vb3A:
20.26
4kt0J-1vb3A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1vb3 THREONINE SYNTHASE
(Escherichia
coli) 		5 / 12 THR A 137
GLY A 135
HIS A 353
ILE A 155
SER A 210
 KPA  A 500 (-2.9A)
KPA  A 500 ( 4.2A)
None
None
None
 1.27A 4pooB-1vb3A:
2.2		 4pooB-1vb3A:
19.33