SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KMP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 ASN A 354
ILE A 219
SER A 146
ASN A 378
 U2F  A1457 (-3.8A)
None
KMP  A1456 (-4.1A)
None
 1.20A 1h7xB-2c1zA:
3.9		 1h7xB-2c1zA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 5 PHE A 121
THR A 141
LEU A 147
ALA A 120
 KMP  A1456 (-4.5A)
U2F  A1457 (-3.9A)
None
None
 1.36A 2e1qD-2c1zA:
undetectable		 2e1qD-2c1zA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 7 PRO A 138
GLY A 208
ALA A 125
GLN A 188
 None
None
None
KMP  A1456 (-4.2A)
 0.74A 4g0uB-2c1zA:
2.2		 4g0uB-2c1zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 PRO A 138
GLY A 208
ALA A 125
GLN A 188
 None
None
None
KMP  A1456 (-4.2A)
 0.85A 4g0uA-2c1zA:
2.0		 4g0uA-2c1zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		3 / 3 LEU A 377
GLY A 143
PHE A 121
 None
None
KMP  A1456 (-4.5A)
 0.58A 6exiC-2c1zA:
5.7		 6exiC-2c1zA:
10.37