SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KKK'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RV5_C_DXCC92_0 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	5li8	PUTATIVE CYTOCHROME P450 126 (Mycobacterium tuberculosis)	4 / 4	VAL A 94 PHE A 246 PHE A 251 VAL A 176	None KKK A 502 (-4.7A) None None	1.48A	3rv5C-5li8A: 1.2 3rv5D-5li8A: 0.9	3rv5C-5li8A: 11.92 3rv5D-5li8A: 11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RV5_C_DXCC92_0 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	5li8	PUTATIVE CYTOCHROME P450 126 (Mycobacterium tuberculosis)	4 / 4	VAL A 225 PHE A 246 PHE A 251 VAL A 164	None KKK A 502 (-4.7A) None None	1.36A	3rv5C-5li8A: 1.2 3rv5D-5li8A: 0.9	3rv5C-5li8A: 11.92 3rv5D-5li8A: 11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HS1_A_VORA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5li8	PUTATIVE CYTOCHROME P450 126 (Mycobacterium tuberculosis)	4 / 8	ILE A 119 GLY A 365 LEU A 250 LEU A 162	None HEM A 501 (-3.3A) KKK A 502 ( 4.4A) None	0.76A	5hs1A-5li8A: 27.9	5hs1A-5li8A: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N5D_A_SAMA306_0 (METHYLTRANSFERASE)	5li8	PUTATIVE CYTOCHROME P450 126 (Mycobacterium tuberculosis)	5 / 12	ALA A 226 VAL A 225 GLU A 208 ARG A 201 PHE A 246	None None None None KKK A 502 (-4.7A)	1.17A	5n5dA-5li8A: undetectable	5n5dA-5li8A: 22.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3RV5_C_DXCC92_0","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","5li8","PUTATIVE CYTOCHROME P450 126","Mycobacterium tuberculosis",4,"VAL A  94;PHE A 246;PHE A 251;VAL A 176","None;KKK A 502 (-4.7A);None;None","1.48A","3rv5C-5li8A:1.2;3rv5D-5li8A:0.9",null],["3RV5_C_DXCC92_0","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","5li8","PUTATIVE CYTOCHROME P450 126","Mycobacterium tuberculosis",4,"VAL A 225;PHE A 246;PHE A 251;VAL A 164","None;KKK A 502 (-4.7A);None;None","1.36A","3rv5C-5li8A:1.2;3rv5D-5li8A:0.9","3rv5C-5li8A:11.92;3rv5D-5li8A:11.92"],["5HS1_A_VORA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","5li8","PUTATIVE CYTOCHROME P450 126","Mycobacterium tuberculosis",4,"ILE A 119;GLY A 365;LEU A 250;LEU A 162","None;HEM A 501 (-3.3A);KKK A 502 ( 4.4A);None","0.76A","5hs1A-5li8A:27.9","3rv5C-5li8A:11.92;3rv5D-5li8A:11.92"],["5N5D_A_SAMA306_0","METHYLTRANSFERASE","5li8","PUTATIVE CYTOCHROME P450 126","Mycobacterium tuberculosis",5,"ALA A 226;VAL A 225;GLU A 208;ARG A 201;PHE A 246","None;None;None;None;KKK A 502 (-4.7A)","1.17A","5n5dA-5li8A:undetectable","5hs1A-5li8A:22.45"]]