SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KJ2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 123
SER A 126
LEU A  34
ILE A  12
ALA A  97
 None
None
KJ2  A1214 ( 4.8A)
None
None
 1.48A 2a58A-2breA:
undetectable
2a58E-2breA:
undetectable		 2a58A-2breA:
23.18
2a58E-2breA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  12
ALA A  97
GLY A 123
SER A 126
LEU A  34
 None
None
None
None
KJ2  A1214 ( 4.8A)
 1.47A 2a58C-2breA:
undetectable
2a58D-2breA:
undetectable		 2a58C-2breA:
23.18
2a58D-2breA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 SER A 138
SER A 140
LEU A  42
THR A 171
 None
None
None
KJ2  A1214 (-4.0A)
 0.91A 4ikjA-2breA:
undetectable
4ikjB-2breA:
undetectable		 4ikjA-2breA:
20.83
4ikjB-2breA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  42
THR A 171
SER A 138
SER A 140
 None
KJ2  A1214 (-4.0A)
None
None
 0.95A 4ikkA-2breA:
undetectable
4ikkB-2breA:
undetectable		 4ikkA-2breA:
20.83
4ikkB-2breA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 SER A  80
LEU A  89
MET A  84
 None
None
KJ2  A1214 (-4.0A)
 0.85A 5ikrB-2breA:
undetectable		 5ikrB-2breA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 142
ASP A  52
ASP A  79
THR A 171
THR A  58
 None
None
KJ2  A1214 (-2.8A)
KJ2  A1214 (-4.0A)
None
 1.17A 6mn1A-2breA:
0.0		 6mn1A-2breA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 142
ASP A  52
ASP A  79
THR A 171
THR A  58
 None
None
KJ2  A1214 (-2.8A)
KJ2  A1214 (-4.0A)
None
 1.15A 6mn1B-2breA:
0.0		 6mn1B-2breA:
21.71