SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KIW'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_B_DCFB853_2 (ADENOSINE DEAMINASE)	4kiw	3-DEHYDROQUINATE DEHYDRATASE (Mycobacterium tuberculosis)	4 / 5	LEU A 13 SER A 115 LEU A 117 GLY A 77	KIW A 500 ( 4.3A) None None KIW A 500 (-3.6A)	1.14A	1a4lB-4kiwA: undetectable	1a4lB-4kiwA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HKU_A_TORA300_2 (CARBONIC ANHYDRASE 2)	4kiw	3-DEHYDROQUINATE DEHYDRATASE (Mycobacterium tuberculosis)	3 / 3	GLU A 99 HIS A 101 THR A 80	None KIW A 500 (-4.2A) None	0.85A	3hkuA-4kiwA: undetectable	3hkuA-4kiwA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IB0_A_DIFA701_1 (LACTOTRANSFERRIN)	4kiw	3-DEHYDROQUINATE DEHYDRATASE (Mycobacterium tuberculosis)	4 / 4	PRO A 21 TYR A 24 GLY A 17 THR A 28	None KIW A 500 (-4.2A) None None	1.49A	3ib0A-4kiwA: undetectable	3ib0A-4kiwA: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_A_MMSA511_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	4kiw	3-DEHYDROQUINATE DEHYDRATASE (Mycobacterium tuberculosis)	4 / 7	HIS A 81 HIS A 101 LEU A 74 SER A 118	KIW A 500 (-3.6A) KIW A 500 (-4.2A) None None	1.06A	5m8rA-4kiwA: undetectable	5m8rA-4kiwA: 16.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A4L_B_DCFB853_2","ADENOSINE DEAMINASE","4kiw","3-DEHYDROQUINATE DEHYDRATASE","Mycobacterium tuberculosis",4,"LEU A  13;SER A 115;LEU A 117;GLY A  77","KIW A 500 ( 4.3A);None;None;KIW A 500 (-3.6A)","1.14A","1a4lB-4kiwA:undetectable",null],["3HKU_A_TORA300_2","CARBONIC ANHYDRASE 2","4kiw","3-DEHYDROQUINATE DEHYDRATASE","Mycobacterium tuberculosis",3,"GLU A  99;HIS A 101;THR A  80","None;KIW A 500 (-4.2A);None","0.85A","3hkuA-4kiwA:undetectable","1a4lB-4kiwA:18.93"],["3IB0_A_DIFA701_1","LACTOTRANSFERRIN","4kiw","3-DEHYDROQUINATE DEHYDRATASE","Mycobacterium tuberculosis",4,"PRO A  21;TYR A  24;GLY A  17;THR A  28","None;KIW A 500 (-4.2A);None;None","1.49A","3ib0A-4kiwA:undetectable","3hkuA-4kiwA:18.46"],["5M8R_A_MMSA511_1","5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE","4kiw","3-DEHYDROQUINATE DEHYDRATASE","Mycobacterium tuberculosis",4,"HIS A  81;HIS A 101;LEU A  74;SER A 118","KIW A 500 (-3.6A);KIW A 500 (-4.2A);None;None","1.06A","5m8rA-4kiwA:undetectable","3ib0A-4kiwA:19.58"]]