SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KIV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 208
PRO A 176
THR A 178
 None
KIV  A 402 (-4.2A)
KIV  A 402 (-2.8A)
 0.92A 1dscC-4ov4A:
undetectable		 1dscC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 178
THR A 208
PRO A 176
 KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
 0.77A 1dscC-4ov4A:
undetectable		 1dscC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 178
THR A 208
PRO A 176
 KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
 0.73A 1fjaC-4ov4A:
undetectable		 1fjaC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 178
THR A 208
PRO A 176
 KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
 0.74A 1fjaD-4ov4A:
undetectable		 1fjaD-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 178
THR A 208
PRO A 176
 KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
 0.86A 1unjW-4ov4A:
undetectable		 1unjW-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 208
PRO A 176
THR A 178
 None
KIV  A 402 (-4.2A)
KIV  A 402 (-2.8A)
 0.87A 1unmF-4ov4A:
undetectable		 1unmF-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 178
THR A 208
PRO A 176
 KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
 0.79A 209dC-4ov4A:
undetectable		 209dC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		3 / 3 THR A 208
PRO A 176
THR A 178
 None
KIV  A 402 (-4.2A)
KIV  A 402 (-2.8A)
 0.85A 316dC-4ov4A:
undetectable		 316dC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		5 / 12 VAL A 120
PHE A 157
PHE A 143
LEU A 175
VAL A 101
 None
None
None
None
KIV  A 402 ( 4.6A)
 1.36A 4nc3A-4ov4A:
undetectable		 4nc3A-4ov4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ov4 2-ISOPROPYLMALATE
SYNTHASE
(Leptospira
biflexa) 		4 / 8 ILE A  72
GLY A  47
VAL A 101
SER A 144
 None
None
KIV  A 402 ( 4.6A)
KIV  A 402 ( 3.7A)
 0.71A 4r20A-4ov4A:
undetectable		 4r20A-4ov4A:
21.66