SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KEG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ASP A  36
PHE A  44
SER A  92
TYR A  96
 None
KEG  A 902 (-3.8A)
None
None
 0.81A 3pglA-2hhlA:
28.9		 3pglA-2hhlA:
75.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5suq ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 227
ARG A 228
ILE A 257
 None
KEG  A 502 (-3.8A)
None
 0.84A 4b7qA-5suqA:
undetectable		 4b7qA-5suqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5suq ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 227
ARG A 228
ILE A 257
 None
KEG  A 502 (-3.8A)
None
 0.80A 4b7qC-5suqA:
undetectable		 4b7qC-5suqA:
21.28