SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KEE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		4 / 5 HIS A 803
LEU A 943
SER A 931
GLY A 975
 KEE  A2033 (-4.0A)
None
None
KEE  A2033 ( 4.9A)
 1.01A 1a4lB-4cbyA:
undetectable		 1a4lB-4cbyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 11 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.68A 1c3sA-4cbyA:
39.8		 1c3sA-4cbyA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 11 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.62A 1c3sA-4cbyA:
39.8		 1c3sA-4cbyA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 9 GLY A 811
PRO A 676
GLY A 974
GLY A 975
ASP A 934
 KEE  A2033 ( 4.2A)
None
KEE  A2033 (-3.6A)
KEE  A2033 ( 4.9A)
ZN  A2034 ( 2.4A)
 1.08A 1mxdA-4cbyA:
undetectable		 1mxdA-4cbyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 GLY A 811
PRO A 676
GLY A 974
GLY A 975
ASP A 934
 KEE  A2033 ( 4.2A)
None
KEE  A2033 (-3.6A)
KEE  A2033 ( 4.9A)
ZN  A2034 ( 2.4A)
 1.08A 1mxgA-4cbyA:
undetectable		 1mxgA-4cbyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.39A 1t69A-4cbyA:
40.0		 1t69A-4cbyA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
PHE A 871
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.69A 1t69A-4cbyA:
40.0		 1t69A-4cbyA:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 HIS A 802
HIS A 803
ASP A 840
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 ( 2.4A)
None
 1.20A 1zz1A-4cbyA:
47.0		 1zz1A-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.48A 1zz1A-4cbyA:
47.0		 1zz1A-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 HIS A 802
HIS A 803
PHE A 812
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.73A 1zz1A-4cbyA:
47.0		 1zz1A-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.39A 1zz1B-4cbyA:
47.1
1zz1C-4cbyA:
47.2		 1zz1B-4cbyA:
32.83
1zz1C-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 HIS A 802
HIS A 803
PHE A 812
HIS A 842
PHE A 871
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.73A 1zz1B-4cbyA:
47.1
1zz1C-4cbyA:
47.2		 1zz1B-4cbyA:
32.83
1zz1C-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.45A 1zz1C-4cbyA:
47.2		 1zz1C-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 9 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.44A 1zz1D-4cbyA:
47.1		 1zz1D-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 9 HIS A 802
HIS A 803
PHE A 812
HIS A 842
PHE A 871
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
 0.75A 1zz1D-4cbyA:
47.1		 1zz1D-4cbyA:
32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 ASP A 840
GLY A 974
GLY A 975
ALA A 980
GLY A 944
 ZN  A2034 (-2.0A)
KEE  A2033 (-3.6A)
KEE  A2033 ( 4.9A)
None
None
 1.05A 2pkkA-4cbyA:
2.1		 2pkkA-4cbyA:
24.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 5 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
 0.21A 3c0zA-4cbyA:
62.9		 3c0zA-4cbyA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 8 HIS A 802
HIS A 803
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.56A 3c0zB-4cbyA:
61.7		 3c0zB-4cbyA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		4 / 8 PHE A 871
ASP A 934
PHE A 812
ASP A 840
 KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
 0.90A 3c0zB-4cbyA:
61.7		 3c0zB-4cbyA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 6 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
 0.19A 3c0zC-4cbyA:
61.6		 3c0zC-4cbyA:
69.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 10 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.26A 4bz6A-4cbyA:
39.2		 4bz6A-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 10 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.26A 4bz6A-4cbyA:
39.2		 4bz6A-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.30A 4bz6A-4cbyA:
39.2
4bz6B-4cbyA:
39.1		 4bz6A-4cbyA:
24.12
4bz6B-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.25A 4bz6A-4cbyA:
39.2
4bz6B-4cbyA:
39.1		 4bz6A-4cbyA:
24.12
4bz6B-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.36A 4bz6C-4cbyA:
39.2		 4bz6C-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.24A 4bz6C-4cbyA:
39.2		 4bz6C-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 10 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.26A 4bz6D-4cbyA:
39.5		 4bz6D-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 10 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.25A 4bz6D-4cbyA:
39.5		 4bz6D-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.38A 4lxzA-4cbyA:
42.4		 4lxzA-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.6A)
 0.57A 4lxzA-4cbyA:
42.4		 4lxzA-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.40A 4lxzB-4cbyA:
42.4		 4lxzB-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 11 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.6A)
 0.62A 4lxzB-4cbyA:
42.4		 4lxzB-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 PRO A 676
HIS A 803
HIS A 842
ASP A 934
GLY A 974
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 1.38A 4lxzB-4cbyA:
42.4		 4lxzB-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.44A 4lxzC-4cbyA:
42.4		 4lxzC-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.61A 4lxzC-4cbyA:
42.4		 4lxzC-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.36A 4qa0A-4cbyA:
40.0		 4qa0A-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.68A 4qa0A-4cbyA:
40.0		 4qa0A-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.41A 4qa0B-4cbyA:
40.0		 4qa0B-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 11 HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.69A 4qa0B-4cbyA:
40.0		 4qa0B-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.60A 4qa2A-4cbyA:
40.0		 4qa2A-4cbyA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.58A 4qa2B-4cbyA:
40.2		 4qa2B-4cbyA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.24A 4qa2B-4cbyA:
40.2		 4qa2B-4cbyA:
28.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.58A 5eeiA-4cbyA:
55.0		 5eeiA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
PHE A 871
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
KEE  A2033 (-3.8A)
 0.63A 5eeiA-4cbyA:
55.0		 5eeiA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.28A 5eeiA-4cbyA:
55.0		 5eeiA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.60A 5eeiB-4cbyA:
55.3		 5eeiB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
PHE A 871
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
KEE  A2033 (-3.8A)
 0.64A 5eeiB-4cbyA:
55.3		 5eeiB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.30A 5eeiB-4cbyA:
55.3		 5eeiB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
ASP A 840
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.24A 5eenA-4cbyA:
55.5		 5eenA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.39A 5eenA-4cbyA:
55.5		 5eenA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.65A 5eenA-4cbyA:
55.5		 5eenA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.58A 5eenB-4cbyA:
55.0		 5eenB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
PHE A 871
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
KEE  A2033 (-3.8A)
None
 0.84A 5eenB-4cbyA:
55.0		 5eenB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.32A 5eenB-4cbyA:
55.0		 5eenB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.37A 5ef8A-4cbyA:
55.2		 5ef8A-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
 0.66A 5ef8A-4cbyA:
55.2		 5ef8A-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.55A 5ef8B-4cbyA:
55.0		 5ef8B-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
None
 0.78A 5ef8B-4cbyA:
55.0		 5ef8B-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.27A 5ef8B-4cbyA:
55.0		 5ef8B-4cbyA:
43.69