SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KAP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_A_SAMA500_0 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	3du4	ADENOSYLMETHIONINE-8 -AMINO-7-OXONONANOAT E AMINOTRANSFERASE (Bacillus subtilis)	6 / 12	ILE A 178 ALA A 223 GLY A 225 VAL A 415 ASN A 144 PHE A 162	None KAP A 451 ( 4.2A) None None None None	1.23A	2okcA-3du4A: undetectable	2okcA-3du4A: 23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_B_SAMB500_0 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	3du4	ADENOSYLMETHIONINE-8 -AMINO-7-OXONONANOAT E AMINOTRANSFERASE (Bacillus subtilis)	6 / 12	ILE A 178 ALA A 223 GLY A 225 VAL A 415 ASN A 144 PHE A 162	None KAP A 451 ( 4.2A) None None None None	1.26A	2okcB-3du4A: undetectable	2okcB-3du4A: 23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWD_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	4a0h	ADENOSYLMETHIONINE-8 -AMINO-7-OXONONANOAT E AMINOTRANSFERASE (Arabidopsis thaliana)	4 / 8	VAL A 780 VAL A 736 TYR A 782 TRP A 370	None None None KAP A1808 ( 4.8A)	1.08A	4pwdC-4a0hA: 2.9	4pwdC-4a0hA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MSD_A_BEZA1202_0 (CARBOXYLIC ACID REDUCTASE)	3du4	ADENOSYLMETHIONINE-8 -AMINO-7-OXONONANOAT E AMINOTRANSFERASE (Bacillus subtilis)	4 / 5	HIS A 163 ILE A 159 PHE A 17 ALA A 223	None None KAP A 451 ( 4.1A) KAP A 451 ( 4.2A)	1.05A	5msdA-3du4A: undetectable	5msdA-3du4A: 18.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OKC_A_SAMA500_0","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","3du4","ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE","Bacillus subtilis",6,"ILE A 178;ALA A 223;GLY A 225;VAL A 415;ASN A 144;PHE A 162","None;KAP A 451 ( 4.2A);None;None;None;None","1.23A","2okcA-3du4A:undetectable",null],["2OKC_B_SAMB500_0","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","3du4","ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE","Bacillus subtilis",6,"ILE A 178;ALA A 223;GLY A 225;VAL A 415;ASN A 144;PHE A 162","None;KAP A 451 ( 4.2A);None;None;None;None","1.26A","2okcB-3du4A:undetectable","2okcA-3du4A:23.87"],["4PWD_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","4a0h","ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE","Arabidopsis thaliana",4,"VAL A 780;VAL A 736;TYR A 782;TRP A 370","None;None;None;KAP A1808 ( 4.8A)","1.08A","4pwdC-4a0hA:2.9","2okcB-3du4A:23.87"],["5MSD_A_BEZA1202_0","CARBOXYLIC ACID REDUCTASE","3du4","ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE","Bacillus subtilis",4,"HIS A 163;ILE A 159;PHE A  17;ALA A 223","None;None;KAP A 451 ( 4.1A);KAP A 451 ( 4.2A)","1.05A","5msdA-3du4A:undetectable","4pwdC-4a0hA:20.92"]]