SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KAI'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1353_1 (PROSTAGLANDIN REDUCTASE 2)	5ikb	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4 (Rattus norvegicus)	5 / 9	VAL A 60 GLY A 140 MET A 143 PHE A 169 ILE A 137	None KAI A 301 (-3.6A) None None KAI A 301 (-3.9A)	1.24A	2w98A-5ikbA: undetectable	2w98A-5ikbA: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	5ikb	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4 (Rattus norvegicus)	5 / 12	SER A 142 GLY A 140 GLY A 139 LEU A 211 ILE A 112	KAI A 301 (-2.6A) KAI A 301 (-3.6A) GOL A 302 (-4.3A) None None	0.95A	3douA-5ikbA: undetectable	3douA-5ikbA: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E9R_A_ACTA700_0 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	3u92	GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3 (Rattus norvegicus)	4 / 6	GLY A 62 GLY A 140 MET A 143 ASN A 71	None KAI A 258 (-3.3A) None None	0.97A	3e9rA-3u92A: undetectable	3e9rA-3u92A: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E9R_C_ACTC700_0 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	3u92	GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3 (Rattus norvegicus)	4 / 6	GLY A 62 GLY A 140 MET A 143 ASN A 71	None KAI A 258 (-3.3A) None None	0.96A	3e9rC-3u92A: undetectable	3e9rC-3u92A: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MI4_A_SPMA201_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	3u92	GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3 (Rattus norvegicus)	4 / 6	ASN A 172 GLU A 189 TYR A 195 GLU A 13	KAI A 258 (-3.1A) KAI A 258 (-2.5A) None KAI A 258 (-3.1A)	1.06A	4mi4A-3u92A: undetectable	4mi4A-3u92A: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MI4_C_SPMC201_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	3u92	GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3 (Rattus norvegicus)	4 / 7	ASN A 172 GLU A 189 TYR A 195 GLU A 13	KAI A 258 (-3.1A) KAI A 258 (-2.5A) None KAI A 258 (-3.1A)	1.07A	4mi4A-3u92A: undetectable 4mi4C-3u92A: undetectable	4mi4A-3u92A: 22.92 4mi4C-3u92A: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JHD_E_EDTE301_0 (BETA-2-MICROGLOBULIN TCRBETA CHAIN)	5ikb	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4 (Rattus norvegicus)	4 / 8	SER A 141 THR A 90 THR A 92 ILE A 110	KAI A 301 ( 3.3A) KAI A 301 (-3.9A) GOL A 302 (-3.0A) None	1.02A	5jhdE-5ikbA: undetectable 5jhdG-5ikbA: undetectable	5jhdE-5ikbA: 21.74 5jhdG-5ikbA: 15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKZ_O_ASCO1004_0 (CYTOCHROME B UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT)	5ikb	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4 (Rattus norvegicus)	4 / 7	HIS A 138 ILE A 137 TYR A 185 ARG A 179	None KAI A 301 (-3.9A) None None	1.15A	5kkzM-5ikbA: undetectable 5kkzO-5ikbA: undetectable	5kkzM-5ikbA: 19.70 5kkzO-5ikbA: 20.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W98_A_P1ZA1353_1","PROSTAGLANDIN REDUCTASE 2","5ikb","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4","Rattus norvegicus",5,"VAL A  60;GLY A 140;MET A 143;PHE A 169;ILE A 137","None;KAI A 301 (-3.6A);None;None;KAI A 301 (-3.9A)","1.24A","2w98A-5ikbA:undetectable",null],["3DOU_A_SAMA1_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","5ikb","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4","Rattus norvegicus",5,"SER A 142;GLY A 140;GLY A 139;LEU A 211;ILE A 112","KAI A 301 (-2.6A);KAI A 301 (-3.6A);GOL A 302 (-4.3A);None;None","0.95A","3douA-5ikbA:undetectable","2w98A-5ikbA:21.22"],["3E9R_A_ACTA700_0","PURINE-NUCLEOSIDE PHOSPHORYLASE","3u92","GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3","Rattus norvegicus",4,"GLY A  62;GLY A 140;MET A 143;ASN A  71","None;KAI A 258 (-3.3A);None;None","0.97A","3e9rA-3u92A:undetectable","3douA-5ikbA:21.85"],["3E9R_C_ACTC700_0","PURINE-NUCLEOSIDE PHOSPHORYLASE","3u92","GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3","Rattus norvegicus",4,"GLY A  62;GLY A 140;MET A 143;ASN A  71","None;KAI A 258 (-3.3A);None;None","0.96A","3e9rC-3u92A:undetectable","3e9rA-3u92A:19.93"],["4MI4_A_SPMA201_1","SPERMIDINE N1-ACETYLTRANSFERASE","3u92","GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3","Rattus norvegicus",4,"ASN A 172;GLU A 189;TYR A 195;GLU A  13","KAI A 258 (-3.1A);KAI A 258 (-2.5A);None;KAI A 258 (-3.1A)","1.06A","4mi4A-3u92A:undetectable","3e9rC-3u92A:19.93"],["4MI4_C_SPMC201_1","SPERMIDINE N1-ACETYLTRANSFERASE;SPERMIDINE N1-ACETYLTRANSFERASE","3u92","GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 3","Rattus norvegicus",4,"ASN A 172;GLU A 189;TYR A 195;GLU A  13","KAI A 258 (-3.1A);KAI A 258 (-2.5A);None;KAI A 258 (-3.1A)","1.07A","4mi4A-3u92A:undetectable;4mi4C-3u92A:undetectable","4mi4A-3u92A:22.92"],["5JHD_E_EDTE301_0","BETA-2-MICROGLOBULIN;TCRBETA CHAIN","5ikb","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4","Rattus norvegicus",4,"SER A 141;THR A  90;THR A  92;ILE A 110","KAI A 301 ( 3.3A);KAI A 301 (-3.9A);GOL A 302 (-3.0A);None","1.02A","5jhdE-5ikbA:undetectable;5jhdG-5ikbA:undetectable","4mi4A-3u92A:22.92;4mi4C-3u92A:22.92"],["5KKZ_O_ASCO1004_0","CYTOCHROME B;UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT","5ikb","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4,GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4","Rattus norvegicus",4,"HIS A 138;ILE A 137;TYR A 185;ARG A 179","None;KAI A 301 (-3.9A);None;None","1.15A","5kkzM-5ikbA:undetectable;5kkzO-5ikbA:undetectable","5jhdE-5ikbA:21.74;5jhdG-5ikbA:15.06"]]