SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'KAA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_A_ADNA433_2 (ADENOSYLHOMOCYSTEINA SE)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	3 / 3	THR A 337 GLU A 494 HIS A 331	KAA A 601 (-4.4A) KAA A 601 (-3.0A) KAA A 601 (-4.2A)	0.89A	1xwfA-6chdA: undetectable	1xwfA-6chdA: 13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_B_ADNB433_2 (ADENOSYLHOMOCYSTEINA SE)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	3 / 3	THR A 337 GLU A 494 HIS A 331	KAA A 601 (-4.4A) KAA A 601 (-3.0A) KAA A 601 (-4.2A)	0.90A	1xwfB-6chdA: undetectable	1xwfB-6chdA: 13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_D_ADND433_2 (ADENOSYLHOMOCYSTEINA SE)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	3 / 3	THR A 337 GLU A 494 HIS A 331	KAA A 601 (-4.4A) KAA A 601 (-3.0A) KAA A 601 (-4.2A)	0.87A	1xwfD-6chdA: undetectable	1xwfD-6chdA: 13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K87_A_ADNA602_1 (PROLINE--TRNA LIGASE)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	4 / 8	ARG A 323 PHE A 335 GLY A 548 THR A 337	KAA A 601 (-2.5A) KAA A 601 (-3.3A) KAA A 601 (-3.7A) KAA A 601 (-4.4A)	0.97A	4k87A-6chdA: 11.2	4k87A-6chdA: 9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PCL_B_SAMB301_0 (O-METHYLTRANSFERASE FAMILY PROTEIN)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	5 / 12	GLN A 515 GLU A 301 GLY A 277 ASN A 272 TYR A 303	None KAA A 601 (-3.0A) KAA A 601 (-4.7A) None None	1.32A	4pclB-6chdA: undetectable	4pclB-6chdA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_A_ADNA602_1 (LYSINE--TRNA LIGASE)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	8 / 10	ARG A 323 GLU A 325 HIS A 331 PHE A 335 GLU A 494 GLY A 550 ARG A 553 ILE A 564	KAA A 601 (-2.5A) KAA A 601 (-3.9A) KAA A 601 (-4.2A) KAA A 601 (-3.3A) KAA A 601 (-3.0A) KAA A 601 (-3.2A) KAA A 601 (-3.8A) None	0.52A	6bniA-6chdA: 51.7	6bniA-6chdA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_B_ADNB602_1 (LYSINE--TRNA LIGASE)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	8 / 10	ARG A 323 GLU A 325 HIS A 331 PHE A 335 GLU A 494 GLY A 550 ARG A 553 ILE A 564	KAA A 601 (-2.5A) KAA A 601 (-3.9A) KAA A 601 (-4.2A) KAA A 601 (-3.3A) KAA A 601 (-3.0A) KAA A 601 (-3.2A) KAA A 601 (-3.8A) None	0.47A	6bniB-6chdA: 52.4	6bniB-6chdA: 18.82

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1XWF_A_ADNA433_2","ADENOSYLHOMOCYSTEINASE","6chd","LYSINE--TRNA LIGASE","Homo sapiens",3,"THR A 337;GLU A 494;HIS A 331","KAA A 601 (-4.4A);KAA A 601 (-3.0A);KAA A 601 (-4.2A)","0.89A","1xwfA-6chdA:undetectable",null],["1XWF_B_ADNB433_2","ADENOSYLHOMOCYSTEINASE","6chd","LYSINE--TRNA LIGASE","Homo sapiens",3,"THR A 337;GLU A 494;HIS A 331","KAA A 601 (-4.4A);KAA A 601 (-3.0A);KAA A 601 (-4.2A)","0.90A","1xwfB-6chdA:undetectable","1xwfA-6chdA:13.64"],["1XWF_D_ADND433_2","ADENOSYLHOMOCYSTEINASE","6chd","LYSINE--TRNA LIGASE","Homo sapiens",3,"THR A 337;GLU A 494;HIS A 331","KAA A 601 (-4.4A);KAA A 601 (-3.0A);KAA A 601 (-4.2A)","0.87A","1xwfD-6chdA:undetectable","1xwfB-6chdA:13.64"],["4K87_A_ADNA602_1","PROLINE--TRNA LIGASE","6chd","LYSINE--TRNA LIGASE","Homo sapiens",4,"ARG A 323;PHE A 335;GLY A 548;THR A 337","KAA A 601 (-2.5A);KAA A 601 (-3.3A);KAA A 601 (-3.7A);KAA A 601 (-4.4A)","0.97A","4k87A-6chdA:11.2","1xwfD-6chdA:13.64"],["4PCL_B_SAMB301_0","O-METHYLTRANSFERASE FAMILY PROTEIN","6chd","LYSINE--TRNA LIGASE","Homo sapiens",5,"GLN A 515;GLU A 301;GLY A 277;ASN A 272;TYR A 303","None;KAA A 601 (-3.0A);KAA A 601 (-4.7A);None;None","1.32A","4pclB-6chdA:undetectable","4k87A-6chdA:9.19"],["6BNI_A_ADNA602_1","LYSINE--TRNA LIGASE","6chd","LYSINE--TRNA LIGASE","Homo sapiens",8,"ARG A 323;GLU A 325;HIS A 331;PHE A 335;GLU A 494;GLY A 550;ARG A 553;ILE A 564","KAA A 601 (-2.5A);KAA A 601 (-3.9A);KAA A 601 (-4.2A);KAA A 601 (-3.3A);KAA A 601 (-3.0A);KAA A 601 (-3.2A);KAA A 601 (-3.8A);None","0.52A","6bniA-6chdA:51.7","4pclB-6chdA:undetectable"],["6BNI_B_ADNB602_1","LYSINE--TRNA LIGASE","6chd","LYSINE--TRNA LIGASE","Homo sapiens",8,"ARG A 323;GLU A 325;HIS A 331;PHE A 335;GLU A 494;GLY A 550;ARG A 553;ILE A 564","KAA A 601 (-2.5A);KAA A 601 (-3.9A);KAA A 601 (-4.2A);KAA A 601 (-3.3A);KAA A 601 (-3.0A);KAA A 601 (-3.2A);KAA A 601 (-3.8A);None","0.47A","6bniB-6chdA:52.4","6bniA-6chdA:18.82"]]