SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'K26'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		8 / 12 THR A 460
HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.46A 1j36A-5l44A:
19.8		 1j36A-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		8 / 12 THR A 460
HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.46A 1j36B-5l44A:
19.6		 1j36B-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.48A 1j37A-5l44A:
19.6		 1j37A-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.47A 1j37B-5l44A:
19.7		 1j37B-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.44A 1o86A-5l44A:
6.0		 1o86A-5l44A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 1v7zA-5l44A:
undetectable		 1v7zA-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 1v7zB-5l44A:
undetectable		 1v7zB-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 1v7zC-5l44A:
undetectable		 1v7zC-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.89A 1v7zD-5l44A:
undetectable		 1v7zD-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.89A 1v7zE-5l44A:
undetectable		 1v7zE-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.87A 1v7zF-5l44A:
undetectable		 1v7zF-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 12 ALA A 418
GLU A 464
HIS A 467
GLU A 492
TYR A 599
 None
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
None
 1.27A 2c6nA-5l44A:
19.6		 2c6nA-5l44A:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		8 / 12 ALA A 418
HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.40A 2c6nA-5l44A:
19.6		 2c6nA-5l44A:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.44A 2c6nB-5l44A:
17.9		 2c6nB-5l44A:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 THR A 460
HIS A 463
GLU A 464
HIS A 467
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
 0.23A 2jihB-5l44A:
undetectable		 2jihB-5l44A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 12 PHE A 591
TRP A 608
SER A 605
TYR A 606
VAL A 491
 None
None
None
SO4  A1004 ( 3.7A)
K26  A1005 (-4.7A)
 1.36A 2rguA-5l44A:
undetectable		 2rguA-5l44A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.40A 2x8zA-5l44A:
19.8		 2x8zA-5l44A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.42A 2x91A-5l44A:
19.8		 2x91A-5l44A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.85A 3a6jA-5l44A:
undetectable		 3a6jA-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.82A 3a6jB-5l44A:
undetectable		 3a6jB-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.83A 3a6jC-5l44A:
undetectable		 3a6jC-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 3a6jE-5l44A:
undetectable		 3a6jE-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.83A 3a6jF-5l44A:
undetectable		 3a6jF-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.54A 4c2pA-5l44A:
17.5		 4c2pA-5l44A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		6 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
TYR A 544
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
None
SO4  A1004 ( 3.7A)
 1.49A 4c2pA-5l44A:
17.5		 4c2pA-5l44A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
SO4  A1004 ( 3.7A)
 0.46A 4r7lA-5l44A:
7.5		 4r7lA-5l44A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_C_MMZC503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 4 TYR A  34
ASN A  84
SER A  87
SER A  86
 None
None
K26  A1005 ( 4.2A)
None
 1.23A 5gsnC-5l44A:
1.1		 5gsnC-5l44A:
21.43