SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'JW5'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JZS_A_MRCA1301_1 (ISOLEUCYL-TRNA SYNTHETASE)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	5 / 11	GLY A 418 SER A 373 GLY A 450 ASP A 259 ILE A 277	JW5  A 482 ( 4.9A) None JW5  A 482 (-3.4A) JW5  A 482 (-2.9A) None	1.24A	1jzsA-2qcmA: undetectable	1jzsA-2qcmA: 16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG7_A_MTXA161_2 (DIHYDROFOLATE REDUCTASE)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	3 / 3	ILE A 446 ILE A 448 THR A 252	None JW5  A 482 ( 4.6A) None	0.61A	1rg7A-2qcmA: undetectable	1rg7A-2qcmA: 20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DU8_A_BEZA352_0 (D-AMINO-ACID OXIDASE)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	4 / 6	LEU A 254 TYR A 466 ILE A 453 GLY A 418	None None None JW5  A 482 ( 4.9A)	0.81A	2du8A-2qcmA: undetectable	2du8A-2qcmA: 24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DU8_B_BEZB1352_0 (D-AMINO-ACID OXIDASE)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	4 / 6	LEU A 254 TYR A 466 ILE A 453 GLY A 418	None None None JW5  A 482 ( 4.9A)	0.84A	2du8B-2qcmA: undetectable	2du8B-2qcmA: 24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_A_SAMA401_1 (METHYLTRANSFERASE NSUN4)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	3 / 3	ASP A 285 ARG A 313 ASP A 259	None None JW5  A 482 (-2.9A)	0.86A	4fp9A-2qcmA: undetectable	4fp9A-2qcmA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_C_SAMC401_1 (METHYLTRANSFERASE NSUN4)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	3 / 3	ASP A 285 ARG A 313 ASP A 259	None None JW5  A 482 (-2.9A)	0.86A	4fp9C-2qcmA: undetectable	4fp9C-2qcmA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_F_SAMF401_1 (METHYLTRANSFERASE NSUN4)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	3 / 3	ASP A 285 ARG A 313 ASP A 259	None None JW5  A 482 (-2.9A)	0.88A	4fp9F-2qcmA: undetectable	4fp9F-2qcmA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNG_B_QPSB601_3 (-)	2qcm	URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (Homo sapiens)	3 / 3	ASP A 289 ASP A 285 ASN A 341	None None JW5  A 482 (-4.3A)	0.83A	6gngB-2qcmA: undetectable	6gngB-2qcmA: 19.64