SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'JPA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_A_BEZA349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifA-2foiA: 2.8	1kifA-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_B_BEZB349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifB-2foiA: 2.8	1kifB-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_C_BEZC349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifC-2foiA: 2.8	1kifC-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_D_BEZD349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifD-2foiA: 2.8	1kifD-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_E_BEZE349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifE-2foiA: 2.8	1kifE-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_F_BEZF349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifF-2foiA: 2.8	1kifF-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_G_BEZG349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifG-2foiA: 2.8	1kifG-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_H_BEZH349_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	0.97A	1kifH-2foiA: 2.8	1kifH-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VE9_A_BEZA352_0 (D-AMINO ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	1.00A	1ve9A-2foiA: 2.7	1ve9A-2foiA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DU8_G_BEZG2352_0 (D-AMINO-ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	1.01A	2du8G-2foiA: 2.8	2du8G-2foiA: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DU8_J_BEZJ3352_0 (D-AMINO-ACID OXIDASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 5	TYR A 267 TYR A 277 ILE A 323 GLY A 313	JPA A 500 (-3.7A) JPA A 500 (-4.4A) JPA A 500 (-4.1A) NAD A 450 (-4.9A)	1.03A	2du8J-2foiA: 2.7	2du8J-2foiA: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TWP_A_SALA404_1 (ANTHRANILATE PHOSPHORIBOSYLTRANSF ERASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 7	ASN A 218 ALA A 219 ALA A 322 ARG A 318	NAD A 450 (-4.1A) JPA A 500 (-4.0A) None None	1.07A	3twpA-2foiA: undetectable	3twpA-2foiA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TWP_B_SALB404_1 (ANTHRANILATE PHOSPHORIBOSYLTRANSF ERASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 7	ASN A 218 ALA A 219 ALA A 322 ARG A 318	NAD A 450 (-4.1A) JPA A 500 (-4.0A) None None	1.03A	3twpB-2foiA: undetectable	3twpB-2foiA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TWP_C_SALC404_1 (ANTHRANILATE PHOSPHORIBOSYLTRANSF ERASE)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	4 / 7	ASN A 218 ALA A 219 ALA A 322 ARG A 318	NAD A 450 (-4.1A) JPA A 500 (-4.0A) None None	1.03A	3twpC-2foiA: undetectable	3twpC-2foiA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BKL_G_EU7G101_0 (MATRIX PROTEIN 2)	2foi	ENOYL-ACYL CARRIER REDUCTASE (Plasmodium falciparum)	5 / 9	ALA A 284 ALA A 219 GLY A 280 GLY A 233 SER A 239	None JPA A 500 (-4.0A) None None None	1.16A	6bklE-2foiA: undetectable 6bklF-2foiA: undetectable 6bklG-2foiA: undetectable 6bklH-2foiA: undetectable	6bklE-2foiA: 6.93 6bklF-2foiA: 6.93 6bklG-2foiA: 6.93 6bklH-2foiA: 6.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KIF_A_BEZA349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifA-2foiA:2.8",null],["1KIF_B_BEZB349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifB-2foiA:2.8","1kifA-2foiA:19.55"],["1KIF_C_BEZC349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifC-2foiA:2.8","1kifB-2foiA:19.55"],["1KIF_D_BEZD349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifD-2foiA:2.8","1kifC-2foiA:19.55"],["1KIF_E_BEZE349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifE-2foiA:2.8","1kifD-2foiA:19.55"],["1KIF_F_BEZF349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifF-2foiA:2.8","1kifE-2foiA:19.55"],["1KIF_G_BEZG349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifG-2foiA:2.8","1kifF-2foiA:19.55"],["1KIF_H_BEZH349_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","0.97A","1kifH-2foiA:2.8","1kifG-2foiA:19.55"],["1VE9_A_BEZA352_0","D-AMINO ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","1.00A","1ve9A-2foiA:2.7","1kifH-2foiA:19.55"],["2DU8_G_BEZG2352_0","D-AMINO-ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","1.01A","2du8G-2foiA:2.8","1ve9A-2foiA:19.55"],["2DU8_J_BEZJ3352_0","D-AMINO-ACID OXIDASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"TYR A 267;TYR A 277;ILE A 323;GLY A 313","JPA A 500 (-3.7A);JPA A 500 (-4.4A);JPA A 500 (-4.1A);NAD A 450 (-4.9A)","1.03A","2du8J-2foiA:2.7","2du8G-2foiA:21.55"],["3TWP_A_SALA404_1","ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"ASN A 218;ALA A 219;ALA A 322;ARG A 318","NAD A 450 (-4.1A);JPA A 500 (-4.0A);None;None","1.07A","3twpA-2foiA:undetectable","2du8J-2foiA:21.55"],["3TWP_B_SALB404_1","ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"ASN A 218;ALA A 219;ALA A 322;ARG A 318","NAD A 450 (-4.1A);JPA A 500 (-4.0A);None;None","1.03A","3twpB-2foiA:undetectable","3twpA-2foiA:18.13"],["3TWP_C_SALC404_1","ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",4,"ASN A 218;ALA A 219;ALA A 322;ARG A 318","NAD A 450 (-4.1A);JPA A 500 (-4.0A);None;None","1.03A","3twpC-2foiA:undetectable","3twpB-2foiA:18.13"],["6BKL_G_EU7G101_0","MATRIX PROTEIN 2","2foi","ENOYL-ACYL CARRIER REDUCTASE","Plasmodium falciparum",5,"ALA A 284;ALA A 219;GLY A 280;GLY A 233;SER A 239","None;JPA A 500 (-4.0A);None;None;None","1.16A","6bklE-2foiA:undetectable;6bklF-2foiA:undetectable;6bklG-2foiA:undetectable;6bklH-2foiA:undetectable","3twpC-2foiA:18.13"]]