SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'JIM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 110
LEU A 102
LEU A 101
ALA A  99
 None
None
None
JIM  A 193 ( 4.0A)
 0.81A 2wekA-3kq0A:
undetectable		 2wekA-3kq0A:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		8 / 12 PHE A  49
PHE A  51
LEU A  62
GLU A  64
ARG A  90
ALA A  99
SER A 125
TYR A 127
 JIM  A 193 (-3.8A)
None
None
None
JIM  A 193 (-4.3A)
JIM  A 193 ( 4.0A)
None
None
 0.80A 3apvA-3kq0A:
27.8		 3apvA-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A  51
HIS A  97
ALA A  99
SER A 125
TYR A 127
 None
None
JIM  A 193 ( 4.0A)
None
None
 0.76A 3apvA-3kq0A:
27.8		 3apvA-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A  51
LEU A  62
ARG A  90
ALA A  99
TYR A 110
 None
None
JIM  A 193 (-4.3A)
JIM  A 193 ( 4.0A)
None
 1.46A 3apvA-3kq0A:
27.8		 3apvA-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		8 / 12 VAL A  41
PHE A  49
PHE A  51
LEU A  62
ARG A  90
ALA A  99
SER A 125
TYR A 127
 None
JIM  A 193 (-3.8A)
None
None
JIM  A 193 (-4.3A)
JIM  A 193 ( 4.0A)
None
None
 0.70A 3apvA-3kq0A:
27.8		 3apvA-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		7 / 12 PHE A  32
PHE A  49
PHE A  51
HIS A  97
ALA A  99
SER A 125
TYR A 127
 None
JIM  A 193 (-3.8A)
None
None
JIM  A 193 ( 4.0A)
None
None
 0.89A 3apvB-3kq0A:
28.1		 3apvB-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		9 / 12 PHE A  32
VAL A  41
PHE A  49
PHE A  51
LEU A  62
GLU A  64
ALA A  99
SER A 125
TYR A 127
 None
None
JIM  A 193 (-3.8A)
None
None
None
JIM  A 193 ( 4.0A)
None
None
 0.68A 3apvB-3kq0A:
28.1		 3apvB-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		8 / 12 PHE A  32
VAL A  41
PHE A  49
PHE A  51
LEU A  62
GLU A  64
ARG A  90
ALA A  99
 None
None
JIM  A 193 (-3.8A)
None
None
None
JIM  A 193 (-4.3A)
JIM  A 193 ( 4.0A)
 0.91A 3apvB-3kq0A:
28.1		 3apvB-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A  51
LEU A  62
ARG A  90
ALA A  99
TYR A 110
 None
None
JIM  A 193 (-4.3A)
JIM  A 193 ( 4.0A)
None
 1.44A 3apvB-3kq0A:
28.1		 3apvB-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		10 / 12 TYR A  27
PHE A  32
VAL A  41
ILE A  44
PHE A  49
PHE A  51
GLU A  64
ALA A  99
SER A 125
TYR A 127
 None
None
None
None
JIM  A 193 (-3.8A)
None
None
JIM  A 193 ( 4.0A)
None
None
 0.73A 3apwA-3kq0A:
28.0		 3apwA-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		9 / 12 VAL A  41
ILE A  44
PHE A  49
PHE A  51
LEU A  62
GLN A  66
ARG A  90
SER A 125
TYR A 127
 None
None
JIM  A 193 (-3.8A)
None
None
None
JIM  A 193 (-4.3A)
None
None
 0.74A 3apwB-3kq0A:
27.6		 3apwB-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		10 / 12 VAL A  41
ILE A  44
PHE A  49
PHE A  51
LEU A  62
GLU A  64
ARG A  90
ALA A  99
SER A 125
TYR A 127
 None
None
JIM  A 193 (-3.8A)
None
None
None
JIM  A 193 (-4.3A)
JIM  A 193 ( 4.0A)
None
None
 0.64A 3apwB-3kq0A:
27.6		 3apwB-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		9 / 12 PHE A  32
VAL A  41
THR A  47
PHE A  49
PHE A  51
GLU A  64
LEU A  79
ALA A  99
TYR A 127
 None
None
None
JIM  A 193 (-3.8A)
None
None
None
JIM  A 193 ( 4.0A)
None
 0.84A 3apxA-3kq0A:
27.6		 3apxA-3kq0A:
86.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens) 		9 / 12 PHE A  32
VAL A  41
THR A  47
PHE A  49
PHE A  51
GLU A  64
LEU A  79
ARG A  90
TYR A 127
 None
None
None
JIM  A 193 (-3.8A)
None
None
None
JIM  A 193 (-4.3A)
None
 0.86A 3apxA-3kq0A:
27.6		 3apxA-3kq0A:
86.24