SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'JHZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 11 TYR A  76
ASP A  33
GLU A 111
HIS A 225
PHE A  72
 SAH  A 502 (-4.4A)
JHZ  A 503 ( 4.3A)
SAH  A 502 ( 4.8A)
JHZ  A 503 (-4.1A)
SAH  A 502 (-3.6A)
 1.28A 2dg3A-5t67A:
undetectable		 2dg3A-5t67A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 10 ILE A 118
HIS A 254
TYR A 174
GLU A 111
ASN A 177
 None
JHZ  A 504 (-3.9A)
None
SAH  A 503 ( 4.8A)
SAH  A 503 ( 3.9A)
 1.46A 2jkcA-4e2zA:
0.0		 2jkcA-4e2zA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 10 ILE A 118
HIS A 254
TYR A 174
GLU A 111
ASN A 177
 None
JHZ  A 503 (-3.8A)
None
SAH  A 502 ( 4.8A)
SAH  A 502 ( 3.7A)
 1.45A 2jkcA-5t67A:
4.0		 2jkcA-5t67A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		3 / 3 SER A 233
HIS A 225
ASP A 219
 None
JHZ  A 503 (-4.1A)
None
 0.86A 2oxtA-5t67A:
6.5		 2oxtA-5t67A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 LEU A 380
GLY A 324
GLY A 322
VAL A 365
THR A 326
 None
JHZ  A 504 (-3.6A)
None
None
JHZ  A 504 (-4.0A)
 1.22A 3dh0A-4e2zA:
14.5		 3dh0A-4e2zA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 504 (-3.6A)
JHZ  A 504 (-2.7A)
JHZ  A 504 (-4.2A)
JHZ  A 504 (-2.9A)
JHZ  A 504 (-3.6A)
 1.03A 3g89A-4e2zA:
10.0		 3g89A-4e2zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 503 (-3.6A)
JHZ  A 503 (-2.6A)
JHZ  A 503 (-4.1A)
JHZ  A 503 (-2.9A)
JHZ  A 503 ( 3.8A)
 0.91A 3g89A-5t67A:
9.8		 3g89A-5t67A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 504 (-3.6A)
JHZ  A 504 (-2.7A)
JHZ  A 504 (-4.2A)
JHZ  A 504 (-2.9A)
JHZ  A 504 (-3.6A)
 0.94A 3g8bA-4e2zA:
10.2		 3g8bA-4e2zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 503 (-3.6A)
JHZ  A 503 (-2.6A)
JHZ  A 503 (-4.1A)
JHZ  A 503 (-2.9A)
JHZ  A 503 ( 3.8A)
 0.83A 3g8bA-5t67A:
9.8		 3g8bA-5t67A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 504 (-3.6A)
JHZ  A 504 (-2.7A)
JHZ  A 504 (-4.2A)
JHZ  A 504 (-2.9A)
JHZ  A 504 (-3.6A)
 1.02A 3g8bB-4e2zA:
9.9		 3g8bB-4e2zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 503 (-3.6A)
JHZ  A 503 (-2.6A)
JHZ  A 503 (-4.1A)
JHZ  A 503 (-2.9A)
JHZ  A 503 ( 3.8A)
 0.89A 3g8bB-5t67A:
9.4		 3g8bB-5t67A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		12 / 12 PHE A  72
TYR A  76
TYR A  78
PHE A  90
GLU A 111
ILE A 112
PHE A 133
PHE A 154
PHE A 155
ALA A 176
THR A 178
ILE A 182
 SAH  A 503 (-3.6A)
SAH  A 503 ( 4.4A)
JHZ  A 504 (-3.2A)
SAH  A 503 (-4.5A)
SAH  A 503 ( 4.8A)
SAH  A 503 (-4.5A)
None
SAH  A 503 (-4.9A)
None
SAH  A 503 (-3.5A)
SAH  A 503 (-3.3A)
SAH  A 503 (-4.4A)
 0.16A 3ndiA-4e2zA:
70.4		 3ndiA-4e2zA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		12 / 12 PHE A  72
TYR A  76
TYR A  78
PHE A  90
GLU A 111
ILE A 112
PHE A 133
PHE A 154
PHE A 155
ALA A 176
THR A 178
ILE A 182
 SAH  A 502 (-3.6A)
SAH  A 502 (-4.4A)
JHZ  A 503 (-3.2A)
SAH  A 502 (-4.5A)
SAH  A 502 ( 4.8A)
SAH  A 502 (-4.4A)
None
SAH  A 502 (-4.9A)
None
SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-4.4A)
 0.26A 3ndiA-5t67A:
66.5		 3ndiA-5t67A:
77.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		9 / 9 SER A  80
GLY A 113
ASN A 115
GLU A 134
PRO A 135
SER A 136
ASN A 177
HIS A 181
TYR A 184
 SAH  A 502 (-2.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.3A)
SAH  A 502 (-2.7A)
SAH  A 502 (-3.9A)
SAH  A 502 (-2.8A)
SAH  A 502 ( 3.7A)
JHZ  A 503 (-3.9A)
EDO  A 506 (-3.9A)
 0.17A 3ndiA-5t67A:
66.5		 3ndiA-5t67A:
77.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 7 TYR A  76
ASP A  33
SER A  32
HIS A 181
 SAH  A 503 ( 4.4A)
JHZ  A 504 ( 4.4A)
None
SAH  A 503 (-4.4A)
 1.29A 4arcA-4e2zA:
undetectable		 4arcA-4e2zA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 TYR A  76
ASP A  33
SER A  32
TYR A  47
 SAH  A 502 (-4.4A)
JHZ  A 503 ( 4.3A)
None
None
 1.32A 4arcA-5t67A:
undetectable		 4arcA-5t67A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 JHZ  A 504 ( 4.9A)
JHZ  A 504 (-4.0A)
JHZ  A 504 (-3.6A)
None
 1.04A 4qw0K-4e2zA:
undetectable		 4qw0K-4e2zA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.5A)
None
 1.01A 4qw0K-5t67A:
undetectable		 4qw0K-5t67A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 JHZ  A 504 ( 4.9A)
JHZ  A 504 (-4.0A)
JHZ  A 504 (-3.6A)
None
 1.03A 4qw0Y-4e2zA:
undetectable		 4qw0Y-4e2zA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.5A)
None
 1.01A 4qw0Y-5t67A:
undetectable		 4qw0Y-5t67A:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		7 / 12 TYR A  76
ILE A 112
GLY A 113
PRO A 135
PHE A 155
HIS A 181
ILE A 182
 SAH  A 502 (-4.4A)
SAH  A 502 (-4.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.9A)
None
JHZ  A 503 (-3.9A)
SAH  A 502 (-4.4A)
 0.35A 4rvdA-5t67A:
53.7		 4rvdA-5t67A:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		7 / 12 ILE A 112
GLY A 113
ASN A 115
PRO A 135
PHE A 155
HIS A 181
ILE A 182
 SAH  A 502 (-4.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.3A)
SAH  A 502 (-3.9A)
None
JHZ  A 503 (-3.9A)
SAH  A 502 (-4.4A)
 0.36A 4rvgA-5t67A:
54.1		 4rvgA-5t67A:
39.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A  82
TYR A  78
HIS A 254
ALA A 327
ILE A 390
 None
JHZ  A 503 (-3.2A)
JHZ  A 503 (-3.8A)
JHZ  A 503 (-3.5A)
JHZ  A 503 (-4.6A)
 1.25A 5igvA-5t67A:
undetectable		 5igvA-5t67A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 6 PHE A  90
SER A  83
HIS A 386
HIS A 254
 SAH  A 502 (-4.5A)
None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.8A)
 1.46A 5ycnA-5t67A:
undetectable		 5ycnA-5t67A:
21.52