SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'JE2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		4 / 8 LEU A   8
PHE A 156
LEU A 131
PHE A 154
 None
None
JE2  A3151 (-4.9A)
None
 0.99A 1wrlC-2anlA:
undetectable
1wrlD-2anlA:
undetectable		 1wrlC-2anlA:
15.19
1wrlD-2anlA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		5 / 12 ASP A  34
GLY A  36
ASN A  39
GLY A  78
ILE A 123
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-3.6A)
None
 0.85A 2f80A-2anlA:
6.1		 2f80A-2anlA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		5 / 12 ASP A  34
GLY A  36
ASN A  39
ILE A  75
ILE A 123
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
None
None
 0.77A 2qakA-2anlA:
6.1		 2qakA-2anlA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		7 / 12 ASP A  34
GLY A  36
SER A  37
TYR A  77
ASP A 214
GLY A 216
SER A 218
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
None
 0.56A 2v0zC-2anlA:
40.1		 2v0zC-2anlA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		7 / 12 ASP A  34
GLY A  36
SER A  37
TYR A  77
PHE A 120
ASP A 214
GLY A 216
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-3.6A)
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
 0.68A 2v0zC-2anlA:
40.1		 2v0zC-2anlA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ASP A  34
GLY A  36
ALA A 118
ASP A 214
GLY A 216
SER A 218
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
None
 0.58A 2v0zO-2anlA:
39.9		 2v0zO-2anlA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ASP A  34
GLY A  36
ALA A 118
PHE A 120
ASP A 214
GLY A 216
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
 1.11A 2v0zO-2anlA:
39.9		 2v0zO-2anlA:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		7 / 12 ASP A  34
GLY A  36
GLY A  78
PHE A 192
ASP A 214
THR A 217
ILE A 300
 JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-4.6A)
JE2  A3151 (-2.5A)
JE2  A3151 (-2.6A)
JE2  A3151 ( 4.5A)
 0.70A 3prsA-2anlA:
35.4		 3prsA-2anlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ASP A  34
GLY A  78
PHE A 192
ILE A 212
THR A 217
ILE A 300
 JE2  A3151 (-3.0A)
JE2  A3151 (-3.6A)
JE2  A3151 (-4.6A)
None
JE2  A3151 (-2.6A)
JE2  A3151 ( 4.5A)
 0.80A 3pwwA-2anlA:
35.2		 3pwwA-2anlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		5 / 8 GLY A  36
SER A  37
ILE A  75
TYR A  77
ASP A 214
 JE2  A3151 (-2.7A)
None
None
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
 0.51A 3pwwA-2anlA:
35.2		 3pwwA-2anlA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ASP A 214
GLY A 216
GLY A  78
ILE A 294
ASP A  34
ILE A 123
 JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
JE2  A3151 (-3.6A)
JE2  A3151 ( 4.8A)
JE2  A3151 (-3.0A)
None
 0.83A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ILE A  32
ASP A  34
GLY A  36
GLY A  78
ASP A 214
ILE A 300
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 4.5A)
 0.48A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ILE A  32
ASP A  34
GLY A  36
GLY A  78
ASP A 214
THR A 217
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 (-2.6A)
 0.52A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ILE A 212
ASP A 214
GLY A 216
GLY A  78
ILE A 294
ASP A  34
 None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
JE2  A3151 (-3.6A)
JE2  A3151 ( 4.8A)
JE2  A3151 (-3.0A)
 0.74A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		4 / 6 SER A  37
ILE A  75
TYR A  77
ASP A 121
 None
None
JE2  A3151 (-3.6A)
None
 0.99A 3q70A-2anlA:
11.9		 3q70A-2anlA:
30.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		7 / 12 ILE A  32
ASP A  34
GLY A  36
ILE A  75
GLY A  78
ASP A 214
ILE A 300
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 4.5A)
 0.61A 3tneA-2anlA:
34.1		 3tneA-2anlA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ILE A 123
ASP A  34
GLY A  36
GLY A  78
ASP A 214
ILE A 300
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 4.5A)
 1.48A 3tneA-2anlA:
34.1		 3tneA-2anlA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		7 / 12 ILE A  32
ASP A  34
GLY A  36
ILE A  75
GLY A  78
ASP A 214
ILE A 300
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
None
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 4.5A)
 0.65A 3tneB-2anlA:
34.1		 3tneB-2anlA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		6 / 12 ILE A 123
ASP A  34
GLY A  36
GLY A  78
ASP A 214
ILE A 300
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 4.5A)
 1.46A 3tneB-2anlA:
34.1		 3tneB-2anlA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		4 / 7 SER A  37
TYR A  77
ILE A 123
THR A 217
 None
JE2  A3151 (-3.6A)
None
JE2  A3151 (-2.6A)
 0.68A 3tneB-2anlA:
34.1		 3tneB-2anlA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		3 / 3 ASP A 214
ASP A  34
ASN A  39
 JE2  A3151 (-2.5A)
JE2  A3151 (-3.0A)
None
 0.65A 4q5mA-2anlA:
9.6		 4q5mA-2anlA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 2anl PLASMEPSIN IV
(Plasmodium
malariae) 		5 / 12 ASP A 214
GLY A 216
GLY A  78
LEU A 290
ILE A 300
 JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
JE2  A3151 (-3.6A)
None
JE2  A3151 ( 4.5A)
 0.78A 6dh6B-2anlA:
6.2		 6dh6B-2anlA:
16.00