SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'J82'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		3 / 3 GLU A1008
HIS A 934
ASP A 807
 None
None
J82  A2000 ( 4.9A)
 0.79A 1i9gA-4bfrA:
undetectable		 1i9gA-4bfrA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		6 / 12 LEU A 909
GLY A 933
ASP A 913
ILE A 930
ALA A 905
ILE A 911
 None
None
None
J82  A2000 (-3.6A)
None
None
 1.44A 1rl8B-4bfrA:
undetectable		 1rl8B-4bfrA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		4 / 6 ILE A 911
ARG A 914
ILE A 930
LEU A 811
 None
None
J82  A2000 (-3.6A)
None
 0.99A 4m51A-4bfrA:
undetectable		 4m51A-4bfrA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		5 / 12 ILE A 845
VAL A 848
THR A 853
MET A 920
ILE A 930
 J82  A2000 ( 4.4A)
J82  A2000 (-3.8A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
 1.08A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		6 / 12 MET A 773
PRO A 779
TRP A 781
ILE A 797
ASP A 856
ASP A 931
 J82  A2000 (-3.9A)
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
J82  A2000 (-4.9A)
 1.02A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		6 / 12 MET A 773
PRO A 779
TRP A 781
ILE A 797
ASP A 856
ILE A 930
 J82  A2000 (-3.9A)
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
J82  A2000 (-3.6A)
 1.05A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		6 / 12 MET A 773
PRO A 779
TRP A 781
ILE A 797
TYR A 833
ILE A 930
 J82  A2000 (-3.9A)
J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
J82  A2000 (-3.7A)
J82  A2000 (-3.6A)
 0.90A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		6 / 12 PRO A 779
TRP A 781
ILE A 797
ASP A 856
THR A 853
ASP A 931
 J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
None
J82  A2000 (-4.9A)
 1.40A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		7 / 12 PRO A 779
TRP A 781
ILE A 797
ASP A 856
THR A 853
MET A 920
ILE A 930
 J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
None
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
 1.28A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		7 / 12 PRO A 779
TRP A 781
ILE A 797
TYR A 833
THR A 853
MET A 920
ILE A 930
 J82  A2000 (-4.5A)
None
J82  A2000 (-4.4A)
J82  A2000 (-3.7A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
 0.79A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		7 / 12 TRP A 781
ILE A 797
TYR A 833
VAL A 848
THR A 853
MET A 920
ILE A 930
 None
J82  A2000 (-4.4A)
J82  A2000 (-3.7A)
J82  A2000 (-3.8A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
 0.75A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		5 / 12 TYR A 833
VAL A 847
THR A 853
MET A 920
ILE A 930
 J82  A2000 (-3.7A)
J82  A2000 (-3.7A)
None
J82  A2000 (-3.6A)
J82  A2000 (-3.6A)
 1.38A 4xe0A-4bfrA:
40.7		 4xe0A-4bfrA:
57.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM
(Mus
musculus) 		3 / 3 GLU A1008
HIS A 934
ASP A 807
 None
None
J82  A2000 ( 4.9A)
 0.72A 5c0oG-4bfrA:
undetectable		 5c0oG-4bfrA:
14.71