SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'J60'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
VAL A  82
VAL A 101
ASN A 149
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
None
 0.76A 1fmoE-2jamA:
19.7		 1fmoE-2jamA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.71A 1fmoE-3hztA:
21.5		 1fmoE-3hztA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 LYS A  49
ILE A  93
ARG A 139
LEU A 147
 None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
 0.73A 1iepB-2xikA:
19.0		 1iepB-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 4 THR A  79
GLY A 101
ASP A 105
ALA A 144
 J60  A1294 ( 4.2A)
J60  A1294 ( 3.8A)
J60  A1294 (-3.2A)
None
 1.24A 1sg9A-2xikA:
undetectable		 1sg9A-2xikA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A  70
LEU A 131
HIS A 138
 J60  A1294 (-3.3A)
None
None
None
None
 0.40A 1uwhA-2xikA:
16.8		 1uwhA-2xikA:
29.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
 0.52A 1uwjA-2xikA:
7.8		 1uwjA-2xikA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
 0.51A 1uwjB-2xikA:
7.8		 1uwjB-2xikA:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 9 LEU A  29
VAL A  37
LEU A  84
LEU A  96
LEU A 100
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
None
None
J60  A1305 (-4.4A)
 0.42A 1xkkA-2jamA:
14.8		 1xkkA-2jamA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 9 VAL A  37
LYS A  52
LEU A  84
LEU A  96
LEU A 100
 J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
None
None
J60  A1305 (-4.4A)
 0.59A 1xkkA-2jamA:
14.8		 1xkkA-2jamA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 11 GLY A  27
VAL A  34
ALA A  47
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.64A 2evaA-2xikA:
19.6		 2evaA-2xikA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
VAL A 101
ASN A 149
ASP A 165
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 (-3.9A)
None
J60  A1305 ( 3.6A)
 0.94A 2fumA-2jamA:
21.2		 2fumA-2jamA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
ASP A 140
LYS A 142
ALA A 144
ASN A 145
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 ( 4.6A)
 0.63A 2fumA-2xikA:
22.0		 2fumA-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
VAL A 101
ASN A 149
ASP A 165
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 (-3.9A)
None
J60  A1305 ( 3.6A)
 0.90A 2fumB-2jamA:
20.9		 2fumB-2jamA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
LYS A 142
ASN A 145
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
None
J60  A1294 ( 4.6A)
 0.68A 2fumB-2xikA:
22.0		 2fumB-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.62A 2fumB-3hztA:
23.3		 2fumB-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		6 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
VAL A 101
ASN A 149
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 (-3.9A)
None
 0.78A 2fumC-2jamA:
21.4		 2fumC-2jamA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
ASN A 145
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
 0.69A 2fumC-2xikA:
20.8		 2fumC-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.80A 2fumC-3hztA:
22.1		 2fumC-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.64A 2fumD-3hztA:
22.1		 2fumD-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.63A 2gqgA-2xikA:
21.0		 2gqgA-2xikA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.55A 2gqgB-2xikA:
28.0		 2gqgB-2xikA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 2hyyA-2xikA:
19.1		 2hyyA-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.78A 2hyyB-2xikA:
19.0		 2hyyB-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.92A 2hyyD-2xikA:
18.9		 2hyyD-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 2oiqA-2xikA:
19.6		 2oiqA-2xikA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.86A 2pl0A-2xikA:
19.9		 2pl0A-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.94A 2pl0A-2xikA:
19.9		 2pl0A-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.73A 2y6oA-2xikA:
20.4		 2y6oA-2xikA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 ALA A  47
GLU A  66
VAL A  69
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.79A 3cs9A-2xikA:
18.8		 3cs9A-2xikA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
VAL A  69
GLY A 101
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.64A 3cs9B-2xikA:
19.7		 3cs9B-2xikA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		4 / 6 LEU A  29
VAL A  37
LYS A  52
LEU A 151
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
None
 0.68A 3cs9D-2jamA:
17.8		 3cs9D-2jamA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 LEU A  82
VAL A  90
LYS A 105
LEU A 206
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
 0.60A 3cs9D-3hztA:
17.7		 3cs9D-3hztA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
LYS A  49
MET A  95
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
 0.71A 3eygA-2xikA:
20.9		 3eygA-2xikA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
MET A  95
SER A 102
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.74A 3eygA-2xikA:
20.9		 3eygA-2xikA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		9 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.74A 3eygA-3hztA:
19.4		 3eygA-3hztA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		9 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.51A 3eygA-3hztA:
19.4		 3eygA-3hztA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
LYS A  49
MET A  95
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.89A 3fupA-2xikA:
27.6		 3fupA-2xikA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 GLY A  27
GLY A  32
VAL A  34
ALA A  47
MET A  95
TYR A  97
SER A 102
LEU A 147
ASP A 158
 J60  A1294 ( 4.1A)
None
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.96A 3fupA-2xikA:
27.6		 3fupA-2xikA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		8 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.77A 3fupA-3hztA:
19.6		 3fupA-3hztA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		8 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.52A 3fupA-3hztA:
19.6		 3fupA-3hztA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.44A 3fupB-3hztA:
19.5		 3fupB-3hztA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
ILE A  93
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.55A 3g5dA-2xikA:
21.0		 3g5dA-2xikA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
ILE A  93
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.50A 3g5dA-2xikA:
21.0		 3g5dA-2xikA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.74A 3g5dB-2xikA:
21.0		 3g5dB-2xikA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 5 LYS A  49
VAL A  69
ILE A  93
TYR A  97
 None
None
None
J60  A1294 (-4.5A)
 1.08A 3gvuA-2xikA:
19.2		 3gvuA-2xikA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.73A 3k5vA-2xikA:
23.7		 3k5vA-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.73A 3k5vB-2xikA:
18.4		 3k5vB-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LYS A  52
VAL A  82
ASP A 165
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
J60  A1305 ( 4.7A)
J60  A1305 ( 3.6A)
 0.75A 3lxkA-2jamA:
20.0		 3lxkA-2jamA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
MET A  95
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.89A 3lxkA-2xikA:
27.4		 3lxkA-2xikA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 1.01A 3lxkA-2xikA:
27.4		 3lxkA-2xikA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.53A 3lxkA-3hztA:
19.7		 3lxkA-3hztA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.67A 3lxnA-2xikA:
27.8		 3lxnA-2xikA:
29.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
VAL A  69
ILE A  93
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.92A 3oezB-2xikA:
19.7		 3oezB-2xikA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.17A 3qfxA-2xikA:
undetectable		 3qfxA-2xikA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.16A 3qfxB-2xikA:
undetectable		 3qfxB-2xikA:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.69A 3qlgA-2xikA:
19.9		 3qlgA-2xikA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.60A 3qlgB-2xikA:
20.6		 3qlgB-2xikA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
TYR A  97
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
None
None
J60  A1294 ( 4.2A)
 0.86A 3rgfA-2xikA:
18.4		 3rgfA-2xikA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		7 / 12 LEU A  29
VAL A  37
ALA A  50
LYS A  52
LEU A  96
MET A  98
LEU A 100
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
None
EDO  A1304 (-4.6A)
J60  A1305 (-4.4A)
 0.67A 3ug2A-2jamA:
16.6		 3ug2A-2jamA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
 0.50A 3wzdA-2xikA:
18.7		 3wzdA-2xikA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
None
None
 0.51A 3wzeA-2xikA:
18.5		 3wzeA-2xikA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.71A 3zosA-2xikA:
17.8		 3zosA-2xikA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.76A 3zosB-2xikA:
17.9		 3zosB-2xikA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.55A 4agcA-2xikA:
17.8		 4agcA-2xikA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 12 LYS A 105
LEU A 128
MET A 153
ASP A 199
ASN A 204
ASP A 220
 GOL  A   1 (-2.7A)
None
GOL  A   1 ( 3.0A)
None
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 1.47A 4an2A-3hztA:
22.0		 4an2A-3hztA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LYS A 105
LEU A 128
MET A 153
ASP A 199
LYS A 201
ASN A 204
ASP A 220
 GOL  A   1 (-2.7A)
None
GOL  A   1 ( 3.0A)
None
None
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 1.26A 4an2A-3hztA:
22.0		 4an2A-3hztA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
None
None
 0.56A 4asdA-2xikA:
23.6		 4asdA-2xikA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A  70
ILE A  93
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.67A 4c8bA-2xikA:
17.9		 4c8bA-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
LEU A  70
ILE A  93
HIS A 138
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
None
None
J60  A1294 (-4.8A)
 0.91A 4c8bA-2xikA:
17.9		 4c8bA-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A  70
ILE A  78
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.60A 4c8bB-2xikA:
17.9		 4c8bB-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
LEU A  70
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.81A 4c8bB-2xikA:
17.9		 4c8bB-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 GLY A  27
GLY A  29
VAL A  34
ALA A  47
TYR A  97
GLY A 101
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
 0.90A 4ckiA-2xikA:
22.9		 4ckiA-2xikA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
ASP A 140
LYS A 142
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.56A 4i41A-2xikA:
29.0		 4i41A-2xikA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 10 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.05A 4km0A-2xikA:
undetectable		 4km0A-2xikA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A 157
THR A 204
LEU A 208
ILE A 124
THR A  79
 J60  A1294 ( 4.2A)
None
None
None
J60  A1294 ( 4.2A)
 1.03A 4km0B-2xikA:
undetectable		 4km0B-2xikA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 10 ALA A  47
MET A  95
LEU A  98
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.6A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.40A 4ks8A-2xikA:
38.7		 4ks8A-2xikA:
38.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 VAL A  34
ALA A  47
MET A  95
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.39A 4l9iA-2xikA:
24.9		 4l9iA-2xikA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 ALA A 225
LEU A 121
LEU A 151
ILE A 107
MET A 137
 GOL  A 602 (-3.2A)
None
GOL  A   1 (-3.4A)
GOL  A 544 ( 4.8A)
J60  A 540 ( 3.5A)
 1.12A 4lnxA-3hztA:
undetectable		 4lnxA-3hztA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.6A)
 0.78A 4mxoA-2xikA:
21.0		 4mxoA-2xikA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.80A 4mxoB-2xikA:
21.1		 4mxoB-2xikA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
ILE A  93
TYR A  97
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.76A 4mxoB-2xikA:
21.1		 4mxoB-2xikA:
29.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		10 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
MET A  95
TYR A  97
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.83A 4mxyA-2xikA:
20.3		 4mxyA-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
MET A  95
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.64A 4mxyB-2xikA:
20.5		 4mxyB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.71A 4mxyB-2xikA:
20.5		 4mxyB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		10 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
MET A  95
TYR A  97
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.83A 4mxzA-2xikA:
20.3		 4mxzA-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
MET A  95
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.64A 4mxzB-2xikA:
20.5		 4mxzB-2xikA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
TYR A  97
GLY A 101
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.71A 4mxzB-2xikA:
20.5		 4mxzB-2xikA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 11 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.96A 4o0sA-3hztA:
23.7		 4o0sA-3hztA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 6 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LEU A 206
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.6A)
 0.51A 4o0wA-3hztA:
23.5		 4o0wA-3hztA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 8 GLY A  29
VAL A  34
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.61A 4ogrA-2xikA:
30.8		 4ogrA-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 8 GLY A  85
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 GOL  A 542 ( 4.8A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.75A 4ogrA-3hztA:
20.6		 4ogrA-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 7 GLY A  30
ALA A  50
ASN A 149
LEU A 151
ASP A 165
 None
J60  A1305 (-3.3A)
None
None
J60  A1305 ( 3.6A)
 1.09A 4ogrE-2jamA:
19.1		 4ogrE-2jamA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 7 GLY A  27
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.91A 4ogrE-2xikA:
29.5		 4ogrE-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 7 GLY A  83
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 ( 4.3A)
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.99A 4ogrE-3hztA:
20.0		 4ogrE-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 9 GLY A  29
VAL A  34
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.62A 4ogrI-2xikA:
21.7		 4ogrI-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 9 GLY A  85
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 GOL  A 542 ( 4.8A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.74A 4ogrI-3hztA:
20.6		 4ogrI-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.63A 4otiA-3hztA:
19.6		 4otiA-3hztA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		9 / 12 ALA A  47
LYS A  49
GLU A  66
THR A  79
ILE A  93
TYR A  97
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 4.2A)
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.62A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
ILE A  93
MET A  95
LEU A 147
ALA A 157
LYS A 288
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
None
 1.40A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
THR A  79
ILE A  93
MET A  95
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
J60  A1294 ( 4.2A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.65A 4qmnA-2xikA:
35.8		 4qmnA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
LEU A  98
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.63A 4qmsA-2xikA:
35.8		 4qmsA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 ALA A  47
LYS A  49
ILE A  93
MET A  95
TYR A  97
LEU A  98
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.69A 4qmsA-2xikA:
35.8		 4qmsA-2xikA:
84.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		10 / 12 GLY A  27
VAL A  34
ALA A  47
THR A  79
MET A  95
TYR A  97
LEU A  98
GLY A  99
LEU A 147
TYR A 287
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 4.2A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.6A)
J60  A1294 ( 3.7A)
J60  A1294 (-4.8A)
None
 0.55A 4qmzA-2xikA:
35.7		 4qmzA-2xikA:
84.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
ARG A 139
ALA A 157
 J60  A1294 (-3.3A)
None
None
TPO  A 174 ( 2.9A)
J60  A1294 ( 4.2A)
 0.85A 4qrcA-2xikA:
18.7		 4qrcA-2xikA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		4 / 8 LEU A  29
VAL A  37
LYS A  52
LEU A 151
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
None
 0.82A 4qrcA-2jamA:
19.4		 4qrcA-2jamA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 10 ALA A  50
LYS A  52
LEU A 100
VAL A 101
LEU A 151
 J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
J60  A1305 (-4.4A)
J60  A1305 (-3.9A)
None
 0.85A 4rz7A-2jamA:
6.1		 4rz7A-2jamA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 VAL A  90
ALA A 103
LYS A 105
PHE A 221
GLY A 222
 None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 (-4.1A)
GOL  A 602 ( 3.7A)
 0.74A 4rzvB-3hztA:
22.1		 4rzvB-3hztA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.71A 4twpA-2xikA:
21.6		 4twpA-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.76A 4twpB-2xikA:
21.4		 4twpB-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 6 VAL A  34
LYS A  49
ARG A 139
ILE A  78
 J60  A1294 ( 4.9A)
None
TPO  A 174 ( 2.9A)
None
 0.73A 4tyjA-2xikA:
19.4		 4tyjA-2xikA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 LEU A  82
VAL A  90
ILE A 136
ILE A 218
 J60  A 540 (-3.8A)
None
None
None
 0.40A 4tyjA-3hztA:
19.2		 4tyjA-3hztA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 LEU A  82
VAL A  90
LYS A 105
ILE A 136
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
None
 0.53A 4tyjA-3hztA:
19.2		 4tyjA-3hztA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 11 VAL A  34
ALA A  47
TYR A  97
GLY A 101
ASN A 145
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.49A 4u5jA-2xikA:
21.1		 4u5jA-2xikA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
LEU A 131
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.56A 4uxqA-2xikA:
19.0		 4uxqA-2xikA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.60A 4v01A-2xikA:
19.3		 4v01A-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.55A 4v01B-2xikA:
19.5		 4v01B-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.63A 4v04A-2xikA:
18.5		 4v04A-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.61A 4v04B-2xikA:
18.6		 4v04B-2xikA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.98A 4wa9B-2xikA:
20.5		 4wa9B-2xikA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.55A 4xliA-2xikA:
21.3		 4xliA-2xikA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.62A 4xliB-2xikA:
20.9		 4xliB-2xikA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 8 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 100
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 (-4.4A)
 0.38A 4zauA-2jamA:
18.7		 4zauA-2jamA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 SER A 465
MET A 527
PHE A 520
GLU A 160
GLY A  83
 None
None
None
GOL  A 542 (-3.8A)
J60  A 540 ( 4.3A)
 1.45A 4zjlA-3hztA:
undetectable		 4zjlA-3hztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		8 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.77A 5bvwA-2xikA:
17.9		 5bvwA-2xikA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.73A 5i9xA-2xikA:
24.9		 5i9xA-2xikA:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		4 / 7 GLY A  30
GLY A  32
PHE A  34
VAL A  37
 None
None
None
J60  A1305 (-4.8A)
 0.26A 5izjB-2jamA:
20.1		 5izjB-2jamA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 7 GLY A  30
GLY A  32
PHE A  34
VAL A  37
LYS A  52
 None
None
None
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
 0.33A 5izjA-2jamA:
20.0		 5izjA-2jamA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		4 / 7 GLY A  30
GLY A  32
VAL A  37
LYS A  52
 None
None
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
 0.31A 5j5xA-2jamA:
19.7		 5j5xA-2jamA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 11 LEU A  82
GLY A  83
VAL A  90
ALA A 103
GLU A 203
LEU A 206
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 (-4.3A)
GOL  A 542 ( 4.6A)
 0.60A 5lvnA-3hztA:
22.0		 5lvnA-3hztA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		6 / 10 LEU A  29
VAL A  37
ALA A  50
VAL A  82
MET A  98
VAL A 101
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 ( 4.7A)
EDO  A1304 (-4.6A)
J60  A1305 (-3.9A)
 0.68A 5n3hA-2jamA:
20.1		 5n3hA-2jamA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 8 ALA A  47
GLU A  66
LEU A 147
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.51A 5owrA-2xikA:
23.0		 5owrA-2xikA:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 ALA A  47
GLU A  66
TYR A  97
GLY A 101
ASP A 105
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-3.2A)
J60  A1294 ( 4.6A)
 0.63A 5vc3A-2xikA:
20.4		 5vc3A-2xikA:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		4 / 4 VAL A  82
LEU A 100
ASN A 149
ASP A 165
 J60  A1305 ( 4.7A)
J60  A1305 (-4.4A)
None
J60  A1305 ( 3.6A)
 1.16A 5vcyA-2jamA:
19.1		 5vcyA-2jamA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.62A 5y80A-2xikA:
25.1		 5y80A-2xikA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 8 LEU A  82
VAL A  90
LYS A 105
ASP A 220
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
J60  A 540 ( 3.6A)
 0.75A 5y9mA-3hztA:
20.1		 5y9mA-3hztA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		6 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LYS A  52
LEU A  96
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
None
 0.54A 5yu9A-2jamA:
16.1		 5yu9A-2jamA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 GLY A  27
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.1A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.77A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		6 / 12 VAL A  34
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.57A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 LYS A  49
LEU A 147
ASP A 158
 None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.69A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		3 / 3 TYR A  97
LEU A 147
ASP A 158
 J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.70A 5zv2B-2xikA:
19.0		 5zv2B-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.69A 6bsdA-2xikA:
17.7		 6bsdA-2xikA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 9 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.28A 6czmA-2jamA:
undetectable
6czmB-2jamA:
undetectable		 6czmA-2jamA:
22.05
6czmB-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 9 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.30A 6czmB-2jamA:
undetectable
6czmC-2jamA:
undetectable		 6czmB-2jamA:
22.05
6czmC-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 8 LEU A 100
THR A 164
VAL A  37
VAL A  82
LEU A  29
 J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
 1.28A 6czmD-2jamA:
undetectable
6czmF-2jamA:
undetectable		 6czmD-2jamA:
22.05
6czmF-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 9 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.30A 6czmD-2jamA:
undetectable
6czmE-2jamA:
undetectable		 6czmD-2jamA:
22.05
6czmE-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens) 		5 / 10 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.29A 6czmE-2jamA:
undetectable
6czmF-2jamA:
undetectable		 6czmE-2jamA:
22.05
6czmF-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 6hd4A-2xikA:
18.3		 6hd4A-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.79A 6hd4B-2xikA:
18.3		 6hd4B-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 6hd6A-2xikA:
23.6		 6hd6A-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 ILE A  93
GLY A 101
ARG A 139
ALA A 157
 None
J60  A1294 ( 3.8A)
TPO  A 174 ( 2.9A)
J60  A1294 ( 4.2A)
 0.64A 6hd6B-2xikA:
18.3		 6hd6B-2xikA:
15.05