SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'J5Z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IW1_A_ASDA1223_1 (CYTOCHROME P450 CYP125)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	ILE A 455 VAL A 223 GLN A 526 PHE A 227 ILE A 234	None None None J5Z A1001 (-4.4A) None	1.25A	3iw1A-3i6rA: undetectable	3iw1A-3i6rA: 22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KK6_B_CELB1701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	LEU A 176 SER A 468 PHE A 469 GLY A 478 SER A 529	J5Z A1001 ( 4.3A) None None FMN A1002 (-3.7A) FMN A1002 (-2.3A)	1.24A	3kk6B-3i6rA: undetectable	3kk6B-3i6rA: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OT2_A_NPSA601_1 (SERUM ALBUMIN)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	LEU A 531 GLY A 192 CYH A 233 LEU A 240 SER A 538	J5Z A1001 (-4.4A) None None None None	1.50A	4ot2A-3i6rA: undetectable	4ot2A-3i6rA: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D4U_A_SAMA301_0 (UNCHARACTERIZED PROTEIN MJ0489)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	HIS A 185 LEU A 187 GLY A 192 GLY A 241 PHE A 227	J5Z A1001 (-4.0A) None None None J5Z A1001 (-4.4A)	1.00A	5d4uA-3i6rA: undetectable	5d4uA-3i6rA: 21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5K9D_A_CE9A402_0 (DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	HIS A 185 LEU A 187 PHE A 227 TYR A 528 LEU A 531	J5Z A1001 (-4.0A) None J5Z A1001 (-4.4A) FMN A1002 (-3.9A) J5Z A1001 (-4.4A)	1.08A	5k9dA-3i6rA: 52.9	5k9dA-3i6rA: 37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VIM_A_SAMA301_0 (METHYLTRANSFERASE)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	GLY A 277 GLY A 226 VAL A 532 PHE A 533 ILE A 272	ORO A1003 (-3.4A) FMN A1002 (-3.0A) J5Z A1001 (-4.2A) None FMN A1002 ( 4.1A)	0.85A	5vimA-3i6rA: undetectable	5vimA-3i6rA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VIM_B_SAMB301_0 (METHYLTRANSFERASE)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	GLY A 277 GLY A 226 VAL A 532 PHE A 533 ILE A 272	ORO A1003 (-3.4A) FMN A1002 (-3.0A) J5Z A1001 (-4.2A) None FMN A1002 ( 4.1A)	0.88A	5vimB-3i6rA: undetectable	5vimB-3i6rA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A93_B_8NUB3001_0 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	5 / 12	VAL A 476 SER A 477 PHE A 533 LEU A 176 VAL A 532	None FMN A1002 (-3.0A) None J5Z A1001 ( 4.3A) J5Z A1001 (-4.2A)	1.33A	6a93B-3i6rA: undetectable	6a93B-3i6rA: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6J20_A_GBQA1201_1 (SUBSTANCE-P RECEPTOR,ENDOLYSIN)	3i6r	DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL (Plasmodium falciparum)	4 / 7	ILE A 272 GLU A 182 HIS A 185 VAL A 532	FMN A1002 ( 4.1A) None J5Z A1001 (-4.0A) J5Z A1001 (-4.2A)	1.11A	6j20A-3i6rA: undetectable	6j20A-3i6rA: 21.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3IW1_A_ASDA1223_1","CYTOCHROME P450 CYP125","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"ILE A 455;VAL A 223;GLN A 526;PHE A 227;ILE A 234","None;None;None;J5Z A1001 (-4.4A);None","1.25A","3iw1A-3i6rA:undetectable",null],["3KK6_B_CELB1701_1","PROSTAGLANDIN G\/H SYNTHASE 1","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"LEU A 176;SER A 468;PHE A 469;GLY A 478;SER A 529","J5Z A1001 ( 4.3A);None;None;FMN A1002 (-3.7A);FMN A1002 (-2.3A)","1.24A","3kk6B-3i6rA:undetectable","3iw1A-3i6rA:22.62"],["4OT2_A_NPSA601_1","SERUM ALBUMIN","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"LEU A 531;GLY A 192;CYH A 233;LEU A 240;SER A 538","J5Z A1001 (-4.4A);None;None;None;None","1.50A","4ot2A-3i6rA:undetectable","3kk6B-3i6rA:20.63"],["5D4U_A_SAMA301_0","UNCHARACTERIZED PROTEIN MJ0489","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"HIS A 185;LEU A 187;GLY A 192;GLY A 241;PHE A 227","J5Z A1001 (-4.0A);None;None;None;J5Z A1001 (-4.4A)","1.00A","5d4uA-3i6rA:undetectable","4ot2A-3i6rA:22.80"],["5K9D_A_CE9A402_0","DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"HIS A 185;LEU A 187;PHE A 227;TYR A 528;LEU A 531","J5Z A1001 (-4.0A);None;J5Z A1001 (-4.4A);FMN A1002 (-3.9A);J5Z A1001 (-4.4A)","1.08A","5k9dA-3i6rA:52.9","5d4uA-3i6rA:21.61"],["5VIM_A_SAMA301_0","METHYLTRANSFERASE","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"GLY A 277;GLY A 226;VAL A 532;PHE A 533;ILE A 272","ORO A1003 (-3.4A);FMN A1002 (-3.0A);J5Z A1001 (-4.2A);None;FMN A1002 ( 4.1A)","0.85A","5vimA-3i6rA:undetectable","5k9dA-3i6rA:37.59"],["5VIM_B_SAMB301_0","METHYLTRANSFERASE","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"GLY A 277;GLY A 226;VAL A 532;PHE A 533;ILE A 272","ORO A1003 (-3.4A);FMN A1002 (-3.0A);J5Z A1001 (-4.2A);None;FMN A1002 ( 4.1A)","0.88A","5vimB-3i6rA:undetectable","5vimA-3i6rA:21.70"],["6A93_B_8NUB3001_0","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",5,"VAL A 476;SER A 477;PHE A 533;LEU A 176;VAL A 532","None;FMN A1002 (-3.0A);None;J5Z A1001 ( 4.3A);J5Z A1001 (-4.2A)","1.33A","6a93B-3i6rA:undetectable","5vimB-3i6rA:21.70"],["6J20_A_GBQA1201_1","SUBSTANCE-P RECEPTOR,ENDOLYSIN","3i6r","DIHYDROOROTATE DEHYDROGENASE HOMOLOG, MITOCHONDRIAL","Plasmodium falciparum",4,"ILE A 272;GLU A 182;HIS A 185;VAL A 532","FMN A1002 ( 4.1A);None;J5Z A1001 (-4.0A);J5Z A1001 (-4.2A)","1.11A","6j20A-3i6rA:undetectable","6a93B-3i6rA:22.47"]]