SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'J24'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_A_SAMA2001_1 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	5v41	POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE) (Mycobacterium tuberculosis)	4 / 6	TYR A1663 GLY A1681 TYR A1674 ASP A1680	J24 A1801 (-4.3A) None J24 A1801 (-3.8A) None	1.28A	2g72A-5v41A: undetectable	2g72A-5v41A: 22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GSS_A_EAAA212_1 (GLUTATHIONE S-TRANSFERASE P1-1)	5v41	POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE) (Mycobacterium tuberculosis)	4 / 7	TYR A1637 VAL A1611 ILE A1575 GLY A1609	J24 A1801 (-4.3A) None None None	0.99A	3gssA-5v41A: undetectable	3gssA-5v41A: 24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GSS_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE P1-1)	5v41	POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE) (Mycobacterium tuberculosis)	4 / 7	TYR A1637 VAL A1611 ILE A1575 GLY A1609	J24 A1801 (-4.3A) None None None	0.99A	3gssB-5v41A: undetectable	3gssB-5v41A: 24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROD_C_NCAC302_0 (NICOTINAMIDE N-METHYLTRANSFERASE)	5v41	POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE) (Mycobacterium tuberculosis)	5 / 10	TYR A1663 TYR A1674 ASP A1639 ALA A1477 ALA A1642	J24 A1801 (-4.3A) J24 A1801 (-3.8A) None None None	1.50A	3rodC-5v41A: 1.2	3rodC-5v41A: 22.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2G72_A_SAMA2001_1","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","5v41","POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE)","Mycobacterium tuberculosis",4,"TYR A1663;GLY A1681;TYR A1674;ASP A1680","J24 A1801 (-4.3A);None;J24 A1801 (-3.8A);None","1.28A","2g72A-5v41A:undetectable",null],["3GSS_A_EAAA212_1","GLUTATHIONE S-TRANSFERASE P1-1","5v41","POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE)","Mycobacterium tuberculosis",4,"TYR A1637;VAL A1611;ILE A1575;GLY A1609","J24 A1801 (-4.3A);None;None;None","0.99A","3gssA-5v41A:undetectable","2g72A-5v41A:22.84"],["3GSS_B_EAAB211_1","GLUTATHIONE S-TRANSFERASE P1-1","5v41","POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE)","Mycobacterium tuberculosis",4,"TYR A1637;VAL A1611;ILE A1575;GLY A1609","J24 A1801 (-4.3A);None;None;None","0.99A","3gssB-5v41A:undetectable","3gssA-5v41A:24.91"],["3ROD_C_NCAC302_0","NICOTINAMIDE N-METHYLTRANSFERASE","5v41","POLYKETIDE SYNTHASE PKS13 (TERMINATION POLYKETIDE SYNTHASE)","Mycobacterium tuberculosis",5,"TYR A1663;TYR A1674;ASP A1639;ALA A1477;ALA A1642","J24 A1801 (-4.3A);J24 A1801 (-3.8A);None;None;None","1.50A","3rodC-5v41A:1.2","3gssB-5v41A:24.91"]]