SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IYR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		6 / 12 ILE A  16
ALA A 209
ALA A  18
ALA A 191
VAL A  63
LEU A  44
 None
None
None
IYR  A  91 ( 4.3A)
None
None
 1.42A 1xiuB-3vn3A:
undetectable		 1xiuB-3vn3A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		6 / 12 ILE A  16
ALA A 209
ALA A  18
ALA A 191
VAL A  63
LEU A  44
 None
None
None
IYR  A  91 ( 4.3A)
None
None
 1.45A 3oapA-3vn3A:
undetectable		 3oapA-3vn3A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		4 / 5 LEU A 190
LEU A   8
GLY A   9
GLY A  12
 IYR  A  91 ( 4.0A)
EDO  A 301 ( 4.9A)
None
None
 0.83A 3si7C-3vn3A:
undetectable
3si7D-3vn3A:
undetectable		 3si7C-3vn3A:
23.43
3si7D-3vn3A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4tvc DEXTRANSUCRASE
(Leuconostoc
mesenteroides) 		5 / 12 PHE A2641
LEU A2166
PHE A2214
VAL A2711
GLU A2327
 None
None
None
IYR  A2712 ( 3.0A)
None
 1.19A 4fiaA-4tvcA:
undetectable		 4fiaA-4tvcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4tvc DEXTRANSUCRASE
(Leuconostoc
mesenteroides) 		5 / 12 PHE A2641
LEU A2166
PHE A2214
VAL A2711
GLU A2327
 None
None
None
IYR  A2712 ( 3.0A)
None
 1.19A 4fiaA-4tvcA:
undetectable		 4fiaA-4tvcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 VAL A 173
ALA A 174
GLY A 127
SER A 124
GLY A 148
 IYR  A  91 ( 3.8A)
IYR  A  91 ( 3.7A)
None
None
None
 1.18A 4mmdB-3vn3A:
undetectable		 4mmdB-3vn3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		6 / 12 ILE A  16
ALA A 209
ALA A  18
ALA A 191
VAL A  63
LEU A  44
 None
None
None
IYR  A  91 ( 4.3A)
None
None
 1.42A 5z12B-3vn3A:
undetectable		 5z12B-3vn3A:
15.70