SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ITI'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 ALA A 719
LEU A 764
THR A 766
LEU A 768
GLY A 772
LEU A 820
THR A 830
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
1.00A 1m17A-3lzbA:
34.0
1m17A-3lzbA:
86.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 ALA A 719
THR A 766
LEU A 768
GLY A 772
LEU A 820
THR A 830
ASP A 831
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.83A 1m17A-3lzbA:
34.0
1m17A-3lzbA:
86.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 694
ALA A 719
THR A 766
LEU A 768
GLY A 772
THR A 830
ASP A 831
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.96A 1m17A-3lzbA:
34.0
1m17A-3lzbA:
86.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
12 / 12 ALA A 719
MET A 742
THR A 766
GLY A 772
CYH A 773
LEU A 775
ASP A 776
ARG A 779
LEU A 820
THR A 830
ASP A 831
PHE A 832
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
None
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
0.75A 1xkkA-3lzbA:
38.3
1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 LEU A 694
VAL A 702
CYH A 751
LEU A 753
LEU A 768
MET A 769
ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.7A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
1.14A 1xkkA-3lzbA:
38.3
1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 LEU A 694
VAL A 702
LEU A 753
LEU A 764
LEU A 768
MET A 769
ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
0.93A 1xkkA-3lzbA:
38.3
1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 LEU A 694
VAL A 702
LYS A 721
LEU A 753
LEU A 764
LEU A 768
ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
0.81A 1xkkA-3lzbA:
38.3
1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A 702
CYH A 751
LEU A 753
LEU A 768
MET A 769
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-3.7A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
None
1.19A 1xkkA-3lzbA:
38.3
1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A 702
LEU A 753
LEU A 764
LEU A 768
MET A 769
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
None
1.01A 1xkkA-3lzbA:
38.3
1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A 702
LYS A 721
LEU A 753
LEU A 764
LEU A 768
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
None
0.95A 1xkkA-3lzbA:
38.3
1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 694
ALA A 719
LEU A 764
THR A 766
GLY A 772
ASP A 776
LEU A 820
THR A 830
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
0.89A 2itoA-3lzbA:
34.0
2itoA-3lzbA:
87.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 694
ALA A 719
THR A 766
GLY A 772
ASP A 776
LEU A 820
THR A 830
ASP A 831
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.76A 2itzA-3lzbA:
34.3
2itzA-3lzbA:
87.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 694
VAL A 702
ALA A 719
THR A 766
ASP A 776
LEU A 820
THR A 830
ASP A 831
ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.87A 2itzA-3lzbA:
34.3
2itzA-3lzbA:
87.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
3 / 3 LEU A 764
LEU A 768
MET A 769
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
0.62A 2itzA-3lzbA:
34.3
2itzA-3lzbA:
87.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
4 / 6 LYS A 704
LEU A 694
ALA A 719
THR A 766
None
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
1.10A 2roxB-3lzbA:
undetectable
2roxB-3lzbA:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
11 / 12 ALA A 719
MET A 742
LEU A 753
THR A 766
LEU A 768
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
0.92A 3bbtB-3lzbA:
37.8
3bbtB-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
11 / 12 VAL A 702
ALA A 719
MET A 742
LEU A 753
THR A 766
LEU A 768
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
0.92A 3bbtB-3lzbA:
37.8
3bbtB-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 ALA A 719
LEU A 764
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
0.88A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 ALA A 719
LEU A 764
THR A 766
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
0.91A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 ALA A 719
MET A 742
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
1.07A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 ALA A 719
MET A 742
THR A 766
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
1.03A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A 702
ALA A 719
LEU A 764
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
0.84A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A 702
ALA A 719
LEU A 764
THR A 766
LEU A 820
THR A 830
ASP A 831
PHE A 832
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
0.87A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A 702
ALA A 719
LYS A 721
LEU A 764
ASP A 831
PHE A 832
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 ( 4.2A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
1.03A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A 702
ALA A 719
LYS A 721
LEU A 764
THR A 766
ASP A 831
PHE A 832
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
1.04A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A 702
ALA A 719
MET A 742
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
1.04A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A 702
ALA A 719
MET A 742
THR A 766
LEU A 820
THR A 830
ASP A 831
PHE A 832
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
1.00A 3bbtD-3lzbA:
37.8
3bbtD-3lzbA:
69.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 8 ALA A 719
LEU A 764
THR A 766
LEU A 768
MET A 769
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
0.82A 3lfaA-3lzbA:
19.2
3lfaA-3lzbA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 8 ALA A 719
LYS A 721
LEU A 764
THR A 766
LEU A 768
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
0.44A 3lfaA-3lzbA:
19.2
3lfaA-3lzbA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 GLY A 697
GLY A 700
VAL A 702
ALA A 719
LEU A 723
LEU A 820
ASP A 831
None
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
None
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
1.13A 3v5wA-3lzbA:
7.5
3v5wA-3lzbA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 GLY A 697
GLY A 700
VAL A 702
ALA A 719
LYS A 721
LEU A 723
ASP A 831
None
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
None
ITI  A   1 ( 4.6A)
1.11A 3v5wA-3lzbA:
7.5
3v5wA-3lzbA:
16.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 ALA A 719
THR A 766
MET A 769
GLY A 772
CYH A 773
LEU A 820
THR A 830
ASP A 831
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.95A 4hjoA-3lzbA:
38.7
4hjoA-3lzbA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A 702
ALA A 719
THR A 766
MET A 769
CYH A 773
LEU A 820
THR A 830
ASP A 831
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
1.03A 4hjoA-3lzbA:
38.7
4hjoA-3lzbA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 LYS A 721
ASN A 818
ASP A 831
PHE A 832
GLY A 833
ITI  A   1 (-2.6A)
None
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
0.92A 4lmnA-3lzbA:
24.5
4lmnA-3lzbA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 11 LEU A 694
ALA A 719
THR A 766
GLY A 772
ASN A 818
LEU A 820
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
0.68A 4wa9A-3lzbA:
28.4
4wa9A-3lzbA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 ALA A 719
LEU A 764
THR A 766
LEU A 768
GLY A 772
ASP A 776
LEU A 820
THR A 830
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
0.88A 4wkqA-3lzbA:
34.6
4wkqA-3lzbA:
86.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 694
ALA A 719
LEU A 764
THR A 766
LEU A 768
GLY A 772
ASP A 776
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
None
0.98A 4wkqA-3lzbA:
34.6
4wkqA-3lzbA:
86.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 753
THR A 766
LEU A 768
GLY A 772
ASP A 776
LEU A 820
THR A 830
ITI  A   1 (-3.8A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
1.42A 4wkqA-3lzbA:
34.6
4wkqA-3lzbA:
86.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
4 / 6 ALA A 719
LEU A 768
MET A 769
LEU A 820
ITI  A   1 (-2.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
0.88A 4xoyA-3lzbA:
20.7
4xoyA-3lzbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
4 / 6 ALA A 719
LEU A 768
MET A 769
LEU A 820
ITI  A   1 (-2.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
0.81A 4xp3A-3lzbA:
21.0
4xp3A-3lzbA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 LEU A 694
ALA A 719
THR A 766
LEU A 768
GLY A 772
LEU A 820
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
0.90A 5h2uA-3lzbA:
32.1
5h2uA-3lzbA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 694
VAL A 702
ALA A 719
LYS A 721
THR A 766
LEU A 768
LEU A 820
ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
0.91A 5h2uA-3lzbA:
32.1
5h2uA-3lzbA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 694
ALA A 719
THR A 766
LEU A 768
GLY A 772
LEU A 820
ASP A 831
ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
1.00A 5h2uB-3lzbA:
32.3
5h2uB-3lzbA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 694
VAL A 702
ALA A 719
LYS A 721
THR A 766
LEU A 768
LEU A 820
ASP A 831
ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
0.99A 5h2uB-3lzbA:
32.3
5h2uB-3lzbA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 GLY A 695
VAL A 702
ALA A 719
LYS A 721
THR A 766
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
0.58A 5hieC-3lzbA:
26.5
5hieC-3lzbA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
4 / 7 GLY A 695
GLY A 697
LYS A 721
LEU A 723
ITI  A   1 ( 4.8A)
None
ITI  A   1 (-2.6A)
None
0.77A 5izfA-3lzbA:
20.4
5izfA-3lzbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 7 GLY A 695
GLY A 697
GLY A 700
VAL A 702
LEU A 723
ITI  A   1 ( 4.8A)
None
None
ITI  A   1 (-4.8A)
None
0.76A 5izjB-3lzbA:
20.1
5izjB-3lzbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
4 / 7 GLY A 695
GLY A 697
VAL A 702
LYS A 721
ITI  A   1 ( 4.8A)
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.6A)
0.44A 5izjA-3lzbA:
20.2
5izjA-3lzbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 9 GLY A 695
VAL A 702
ALA A 719
LEU A 768
LEU A 820
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
0.92A 5lw1H-3lzbA:
19.3
5lw1H-3lzbA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
4 / 5 LEU A 753
CYH A 751
LEU A 820
ASP A 831
ITI  A   1 (-3.8A)
ITI  A   1 (-3.7A)
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
1.46A 5mafA-3lzbA:
22.9
5mafA-3lzbA:
11.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
10 / 12 LEU A 694
GLY A 695
VAL A 702
ALA A 719
LYS A 721
MET A 742
LEU A 764
CYH A 773
THR A 830
ASP A 831
ITI  A   1 (-3.9A)
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.79A 5yu9A-3lzbA:
39.0
5yu9A-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
10 / 12 LEU A 694
GLY A 695
VAL A 702
ALA A 719
MET A 742
LEU A 764
CYH A 773
LEU A 820
THR A 830
ASP A 831
ITI  A   1 (-3.9A)
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.76A 5yu9A-3lzbA:
39.0
5yu9A-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
11 / 12 GLY A 695
VAL A 702
ALA A 719
LYS A 721
MET A 742
LEU A 764
CYH A 773
ASP A 776
LEU A 820
THR A 830
ASP A 831
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.69A 5yu9B-3lzbA:
38.9
5yu9B-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
9 / 12 ALA A 719
LYS A 721
MET A 742
LEU A 764
GLY A 772
CYH A 773
ASP A 776
THR A 830
ASP A 831
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.76A 5yu9C-3lzbA:
38.9
5yu9C-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 LEU A 753
GLY A 772
CYH A 773
ASP A 776
THR A 830
ASP A 831
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
1.29A 5yu9C-3lzbA:
38.9
5yu9C-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
9 / 12 VAL A 702
ALA A 719
LYS A 721
MET A 742
LEU A 764
CYH A 773
ASP A 776
THR A 830
ASP A 831
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.75A 5yu9C-3lzbA:
38.9
5yu9C-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
10 / 12 ALA A 719
LYS A 721
MET A 742
GLY A 772
CYH A 773
ASP A 776
LEU A 820
THR A 830
ASP A 831
LEU A 834
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
None
0.79A 5yu9D-3lzbA:
39.0
5yu9D-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
10 / 12 VAL A 702
ALA A 719
LYS A 721
MET A 742
CYH A 773
ASP A 776
LEU A 820
THR A 830
ASP A 831
LEU A 834
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
None
0.80A 5yu9D-3lzbA:
39.0
5yu9D-3lzbA:
95.00