SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ITI'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1M17_A_AQ4A999_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | ALA A 719LEU A 764THR A 766LEU A 768GLY A 772LEU A 820THR A 830 | ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 (-3.8A) | 1.00A | 1m17A-3lzbA:34.0 | 1m17A-3lzbA:86.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1M17_A_AQ4A999_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | ALA A 719THR A 766LEU A 768GLY A 772LEU A 820THR A 830ASP A 831 | ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.83A | 1m17A-3lzbA:34.0 | 1m17A-3lzbA:86.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1M17_A_AQ4A999_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | LEU A 694ALA A 719THR A 766LEU A 768GLY A 772THR A 830ASP A 831 | ITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.96A | 1m17A-3lzbA:34.0 | 1m17A-3lzbA:86.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 12 / 12 | ALA A 719MET A 742THR A 766GLY A 772CYH A 773LEU A 775ASP A 776ARG A 779LEU A 820THR A 830ASP A 831PHE A 832 | ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 (-3.8A)ITI A 1 (-3.5A)ITI A 1 (-4.8A)NoneNoneNoneITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A) | 0.75A | 1xkkA-3lzbA:38.3 | 1xkkA-3lzbA:87.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_2 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | LEU A 694VAL A 702CYH A 751LEU A 753LEU A 768MET A 769 | ITI A 1 (-3.9A)ITI A 1 (-4.8A)ITI A 1 (-3.7A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-4.8A) | 1.14A | 1xkkA-3lzbA:38.3 | 1xkkA-3lzbA:87.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_2 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | LEU A 694VAL A 702LEU A 753LEU A 764LEU A 768MET A 769 | ITI A 1 (-3.9A)ITI A 1 (-4.8A)ITI A 1 (-3.8A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A)ITI A 1 (-4.8A) | 0.93A | 1xkkA-3lzbA:38.3 | 1xkkA-3lzbA:87.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_2 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | LEU A 694VAL A 702LYS A 721LEU A 753LEU A 764LEU A 768 | ITI A 1 (-3.9A)ITI A 1 (-4.8A)ITI A 1 (-2.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A) | 0.81A | 1xkkA-3lzbA:38.3 | 1xkkA-3lzbA:87.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_2 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A 702CYH A 751LEU A 753LEU A 768MET A 769LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-3.7A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-4.8A)None | 1.19A | 1xkkA-3lzbA:38.3 | 1xkkA-3lzbA:87.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_2 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A 702LEU A 753LEU A 764LEU A 768MET A 769LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-3.8A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A)ITI A 1 (-4.8A)None | 1.01A | 1xkkA-3lzbA:38.3 | 1xkkA-3lzbA:87.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_2 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A 702LYS A 721LEU A 753LEU A 764LEU A 768LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-2.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A)None | 0.95A | 1xkkA-3lzbA:38.3 | 1xkkA-3lzbA:87.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITO_A_IREA2020_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | LEU A 694ALA A 719LEU A 764THR A 766GLY A 772ASP A 776LEU A 820THR A 830 | ITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-3.5A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A) | 0.89A | 2itoA-3lzbA:34.0 | 2itoA-3lzbA:87.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITZ_A_IREA2021_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | LEU A 694ALA A 719THR A 766GLY A 772ASP A 776LEU A 820THR A 830ASP A 831 | ITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-3.5A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.76A | 2itzA-3lzbA:34.3 | 2itzA-3lzbA:87.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITZ_A_IREA2021_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | LEU A 694VAL A 702ALA A 719THR A 766ASP A 776LEU A 820THR A 830ASP A 831 | ITI A 1 (-3.9A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-3.8A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.87A | 2itzA-3lzbA:34.3 | 2itzA-3lzbA:87.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITZ_A_IREA2021_2 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 3 / 3 | LEU A 764LEU A 768MET A 769 | ITI A 1 ( 4.2A)ITI A 1 (-4.8A)ITI A 1 (-4.8A) | 0.62A | 2itzA-3lzbA:34.3 | 2itzA-3lzbA:87.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ROX_B_T44B128_1 (TRANSTHYRETIN) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 4 / 6 | LYS A 704LEU A 694ALA A 719THR A 766 | NoneITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 (-3.8A) | 1.10A | 2roxB-3lzbA:undetectable | 2roxB-3lzbA:16.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_B_FMMB91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 11 / 12 | ALA A 719MET A 742LEU A 753THR A 766LEU A 768GLY A 772LEU A 820THR A 830ASP A 831PHE A 832LEU A 834 | ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 (-3.8A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 0.92A | 3bbtB-3lzbA:37.8 | 3bbtB-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_B_FMMB91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 11 / 12 | VAL A 702ALA A 719MET A 742LEU A 753THR A 766LEU A 768LEU A 820THR A 830ASP A 831PHE A 832LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 (-3.8A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 0.92A | 3bbtB-3lzbA:37.8 | 3bbtB-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | ALA A 719LEU A 764GLY A 772LEU A 820THR A 830ASP A 831PHE A 832LEU A 834 | ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 0.88A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | ALA A 719LEU A 764THR A 766GLY A 772LEU A 820THR A 830ASP A 831PHE A 832 | ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A) | 0.91A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | ALA A 719MET A 742GLY A 772LEU A 820THR A 830ASP A 831PHE A 832LEU A 834 | ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 1.07A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | ALA A 719MET A 742THR A 766GLY A 772LEU A 820THR A 830ASP A 831PHE A 832 | ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 (-3.8A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A) | 1.03A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A 702ALA A 719LEU A 764LEU A 820THR A 830ASP A 831PHE A 832LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 0.84A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A 702ALA A 719LEU A 764THR A 766LEU A 820THR A 830ASP A 831PHE A 832 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A) | 0.87A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A 702ALA A 719LYS A 721LEU A 764ASP A 831PHE A 832LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 ( 4.2A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 1.03A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A 702ALA A 719LYS A 721LEU A 764THR A 766ASP A 831PHE A 832 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A) | 1.04A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A 702ALA A 719MET A 742LEU A 820THR A 830ASP A 831PHE A 832LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 1.04A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BBT_D_FMMD91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A 702ALA A 719MET A 742THR A 766LEU A 820THR A 830ASP A 831PHE A 832 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 (-3.8A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)ITI A 1 (-3.6A) | 1.00A | 3bbtD-3lzbA:37.8 | 3bbtD-3lzbA:69.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LFA_A_1N1A361_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 8 | ALA A 719LEU A 764THR A 766LEU A 768MET A 769 | ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-4.8A) | 0.82A | 3lfaA-3lzbA:19.2 | 3lfaA-3lzbA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LFA_A_1N1A361_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 8 | ALA A 719LYS A 721LEU A 764THR A 766LEU A 768 | ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-4.8A) | 0.44A | 3lfaA-3lzbA:19.2 | 3lfaA-3lzbA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V5W_A_8PRA701_1 (G-PROTEIN COUPLEDRECEPTOR KINASE 2) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | GLY A 697GLY A 700VAL A 702ALA A 719LEU A 723LEU A 820ASP A 831 | NoneNoneITI A 1 (-4.8A)ITI A 1 (-2.9A)NoneITI A 1 (-4.6A)ITI A 1 ( 4.6A) | 1.13A | 3v5wA-3lzbA:7.5 | 3v5wA-3lzbA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V5W_A_8PRA701_1 (G-PROTEIN COUPLEDRECEPTOR KINASE 2) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | GLY A 697GLY A 700VAL A 702ALA A 719LYS A 721LEU A 723ASP A 831 | NoneNoneITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)NoneITI A 1 ( 4.6A) | 1.11A | 3v5wA-3lzbA:7.5 | 3v5wA-3lzbA:16.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4HJO_A_AQ4A1001_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | ALA A 719THR A 766MET A 769GLY A 772CYH A 773LEU A 820THR A 830ASP A 831 | ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)ITI A 1 (-4.8A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.95A | 4hjoA-3lzbA:38.7 | 4hjoA-3lzbA:88.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4HJO_A_AQ4A1001_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A 702ALA A 719THR A 766MET A 769CYH A 773LEU A 820THR A 830ASP A 831 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-4.8A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 1.03A | 4hjoA-3lzbA:38.7 | 4hjoA-3lzbA:88.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LMN_A_EUIA503_1 (DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | LYS A 721ASN A 818ASP A 831PHE A 832GLY A 833 | ITI A 1 (-2.6A)NoneITI A 1 ( 4.6A)ITI A 1 (-3.6A)None | 0.92A | 4lmnA-3lzbA:24.5 | 4lmnA-3lzbA:23.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WA9_A_AXIA9000_1 (TYROSINE-PROTEINKINASE ABL1) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 11 | LEU A 694ALA A 719THR A 766GLY A 772ASN A 818LEU A 820 | ITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-3.5A)NoneITI A 1 (-4.6A) | 0.68A | 4wa9A-3lzbA:28.4 | 4wa9A-3lzbA:34.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WKQ_A_IREA1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | ALA A 719LEU A 764THR A 766LEU A 768GLY A 772ASP A 776LEU A 820THR A 830 | ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A) | 0.88A | 4wkqA-3lzbA:34.6 | 4wkqA-3lzbA:86.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WKQ_A_IREA1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | LEU A 694ALA A 719LEU A 764THR A 766LEU A 768GLY A 772ASP A 776 | ITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 ( 4.2A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)None | 0.98A | 4wkqA-3lzbA:34.6 | 4wkqA-3lzbA:86.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WKQ_A_IREA1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | LEU A 753THR A 766LEU A 768GLY A 772ASP A 776LEU A 820THR A 830 | ITI A 1 (-3.8A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A) | 1.42A | 4wkqA-3lzbA:34.6 | 4wkqA-3lzbA:86.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XOY_A_DX4A401_0 (MITOGEN-ACTIVATEDPROTEIN KINASE 1) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 4 / 6 | ALA A 719LEU A 768MET A 769LEU A 820 | ITI A 1 (-2.9A)ITI A 1 (-4.8A)ITI A 1 (-4.8A)ITI A 1 (-4.6A) | 0.88A | 4xoyA-3lzbA:20.7 | 4xoyA-3lzbA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XP3_A_DX4A401_0 (MITOGEN-ACTIVATEDPROTEIN KINASE 1) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 4 / 6 | ALA A 719LEU A 768MET A 769LEU A 820 | ITI A 1 (-2.9A)ITI A 1 (-4.8A)ITI A 1 (-4.8A)ITI A 1 (-4.6A) | 0.81A | 4xp3A-3lzbA:21.0 | 4xp3A-3lzbA:22.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_A_1N1A501_1 (PROTEIN-TYROSINEKINASE 6) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | LEU A 694ALA A 719THR A 766LEU A 768GLY A 772LEU A 820 | ITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)ITI A 1 (-4.6A) | 0.90A | 5h2uA-3lzbA:32.1 | 5h2uA-3lzbA:30.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_A_1N1A501_1 (PROTEIN-TYROSINEKINASE 6) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | LEU A 694VAL A 702ALA A 719LYS A 721THR A 766LEU A 768LEU A 820 | ITI A 1 (-3.9A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-4.6A) | 0.91A | 5h2uA-3lzbA:32.1 | 5h2uA-3lzbA:30.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_B_1N1B501_1 (PROTEIN-TYROSINEKINASE 6) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | LEU A 694ALA A 719THR A 766LEU A 768GLY A 772LEU A 820ASP A 831 | ITI A 1 (-3.9A)ITI A 1 (-2.9A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-3.5A)ITI A 1 (-4.6A)ITI A 1 ( 4.6A) | 1.00A | 5h2uB-3lzbA:32.3 | 5h2uB-3lzbA:30.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_B_1N1B501_1 (PROTEIN-TYROSINEKINASE 6) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | LEU A 694VAL A 702ALA A 719LYS A 721THR A 766LEU A 768LEU A 820ASP A 831 | ITI A 1 (-3.9A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.8A)ITI A 1 (-4.8A)ITI A 1 (-4.6A)ITI A 1 ( 4.6A) | 0.99A | 5h2uB-3lzbA:32.3 | 5h2uB-3lzbA:30.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_C_P06C801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | GLY A 695VAL A 702ALA A 719LYS A 721THR A 766 | ITI A 1 ( 4.8A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.8A) | 0.58A | 5hieC-3lzbA:26.5 | 5hieC-3lzbA:27.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IZF_E_AZ1E2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA6J9-ZEU-DAR-ACA-DAR-NH2) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 4 / 7 | GLY A 695GLY A 697LYS A 721LEU A 723 | ITI A 1 ( 4.8A)NoneITI A 1 (-2.6A)None | 0.77A | 5izfA-3lzbA:20.4 | 5izfA-3lzbA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IZJ_F_AZ1F2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAR-DAR-DAR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 7 | GLY A 695GLY A 697GLY A 700VAL A 702LEU A 723 | ITI A 1 ( 4.8A)NoneNoneITI A 1 (-4.8A)None | 0.76A | 5izjB-3lzbA:20.1 | 5izjB-3lzbA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IZJ_G_AZ1G2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAR-DAR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 4 / 7 | GLY A 695GLY A 697VAL A 702LYS A 721 | ITI A 1 ( 4.8A)NoneITI A 1 (-4.8A)ITI A 1 (-2.6A) | 0.44A | 5izjA-3lzbA:20.2 | 5izjA-3lzbA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5LW1_H_ADNH401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 8) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 9 | GLY A 695VAL A 702ALA A 719LEU A 768LEU A 820 | ITI A 1 ( 4.8A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-4.8A)ITI A 1 (-4.6A) | 0.92A | 5lw1H-3lzbA:19.3 | 5lw1H-3lzbA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MAF_A_XINA403_2 (MATERNAL EMBRYONICLEUCINE ZIPPERKINASE) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 4 / 5 | LEU A 753CYH A 751LEU A 820ASP A 831 | ITI A 1 (-3.8A)ITI A 1 (-3.7A)ITI A 1 (-4.6A)ITI A 1 ( 4.6A) | 1.46A | 5mafA-3lzbA:22.9 | 5mafA-3lzbA:11.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_A_1E8A1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 10 / 12 | LEU A 694GLY A 695VAL A 702ALA A 719LYS A 721MET A 742LEU A 764CYH A 773THR A 830ASP A 831 | ITI A 1 (-3.9A)ITI A 1 ( 4.8A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.4A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.79A | 5yu9A-3lzbA:39.0 | 5yu9A-3lzbA:95.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_A_1E8A1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 10 / 12 | LEU A 694GLY A 695VAL A 702ALA A 719MET A 742LEU A 764CYH A 773LEU A 820THR A 830ASP A 831 | ITI A 1 (-3.9A)ITI A 1 ( 4.8A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-3.4A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A)ITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.76A | 5yu9A-3lzbA:39.0 | 5yu9A-3lzbA:95.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_B_1E8B1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 11 / 12 | GLY A 695VAL A 702ALA A 719LYS A 721MET A 742LEU A 764CYH A 773ASP A 776LEU A 820THR A 830ASP A 831 | ITI A 1 ( 4.8A)ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.4A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.69A | 5yu9B-3lzbA:38.9 | 5yu9B-3lzbA:95.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_C_1E8C1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 9 / 12 | ALA A 719LYS A 721MET A 742LEU A 764GLY A 772CYH A 773ASP A 776THR A 830ASP A 831 | ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.4A)ITI A 1 ( 4.2A)ITI A 1 (-3.5A)ITI A 1 (-4.8A)NoneITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.76A | 5yu9C-3lzbA:38.9 | 5yu9C-3lzbA:95.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_C_1E8C1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | LEU A 753GLY A 772CYH A 773ASP A 776THR A 830ASP A 831 | ITI A 1 (-3.8A)ITI A 1 (-3.5A)ITI A 1 (-4.8A)NoneITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 1.29A | 5yu9C-3lzbA:38.9 | 5yu9C-3lzbA:95.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_C_1E8C1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 9 / 12 | VAL A 702ALA A 719LYS A 721MET A 742LEU A 764CYH A 773ASP A 776THR A 830ASP A 831 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.4A)ITI A 1 ( 4.2A)ITI A 1 (-4.8A)NoneITI A 1 (-3.8A)ITI A 1 ( 4.6A) | 0.75A | 5yu9C-3lzbA:38.9 | 5yu9C-3lzbA:95.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_D_1E8D1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 10 / 12 | ALA A 719LYS A 721MET A 742GLY A 772CYH A 773ASP A 776LEU A 820THR A 830ASP A 831LEU A 834 | ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.4A)ITI A 1 (-3.5A)ITI A 1 (-4.8A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)None | 0.79A | 5yu9D-3lzbA:39.0 | 5yu9D-3lzbA:95.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5YU9_D_1E8D1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3lzb | EPIDERMAL GROWTHFACTOR RECEPTOR (Homosapiens) | 10 / 12 | VAL A 702ALA A 719LYS A 721MET A 742CYH A 773ASP A 776LEU A 820THR A 830ASP A 831LEU A 834 | ITI A 1 (-4.8A)ITI A 1 (-2.9A)ITI A 1 (-2.6A)ITI A 1 (-3.4A)ITI A 1 (-4.8A)NoneITI A 1 (-4.6A)ITI A 1 (-3.8A)ITI A 1 ( 4.6A)None | 0.80A | 5yu9D-3lzbA:39.0 | 5yu9D-3lzbA:95.00 |