SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ISZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		6 / 6 PHE A  38
TYR A  69
CYH A  70
VAL A  95
THR A 109
PHE A 204
 ISZ  A1276 (-4.4A)
ISZ  A1276 (-3.8A)
ISZ  A1276 (-2.4A)
ISZ  A1276 (-4.5A)
None
ISZ  A1276 (-4.4A)
 0.38A 3ltwA-1w6fA:
43.4		 3ltwA-1w6fA:
61.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1w6f ARYLAMINE
N-ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 135
GLN A 133
PHE A 130
LEU A 125
 None
None
ISZ  A1276 (-4.0A)
None
 0.97A 5iy5C-1w6fA:
undetectable
5iy5J-1w6fA:
undetectable		 5iy5C-1w6fA:
22.30
5iy5J-1w6fA:
14.29