SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ISC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I7Q_A_BEZA1501_0 (ANTHRANILATE SYNTHASE)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	9 / 11	GLU A 197 GLY A 214 GLU A 241 HIS A 276 LEU A 304 ARG A 347 GLY A 363 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 ( 4.4A) ISC A 401 (-3.5A) ISC A 401 (-3.3A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.48A	1i7qA-5jzdA: 36.1	1i7qA-5jzdA: 25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I7Q_C_BEZC1502_0 (ANTHRANILATE SYNTHASE)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	8 / 10	GLU A 197 GLY A 214 GLU A 241 HIS A 276 ARG A 347 GLY A 363 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 (-3.5A) ISC A 401 (-3.3A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.45A	1i7qC-5jzdA: 24.5	1i7qC-5jzdA: 25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_A_1FLA2001_1 (SERUM ALBUMIN)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	5 / 11	ARG A 347 VAL A 149 GLY A 363 LEU A 304 SER A 195	ISC A 401 (-3.5A) None ISC A 401 (-3.3A) ISC A 401 ( 4.4A) None	1.07A	2bxeA-5jzdA: undetectable	2bxeA-5jzdA: 23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FN1_A_SALA506_1 (SALICYLATE SYNTHETASE, IRP9)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	8 / 11	GLU A 197 GLY A 214 GLU A 241 HIS A 276 ARG A 347 GLY A 363 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 (-3.5A) ISC A 401 (-3.3A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.49A	2fn1A-5jzdA: 40.2	2fn1A-5jzdA: 28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FN1_B_SALB503_1 (SALICYLATE SYNTHETASE, IRP9)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	8 / 11	GLU A 197 GLY A 214 GLU A 241 HIS A 276 ARG A 347 GLY A 363 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 (-3.5A) ISC A 401 (-3.3A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.53A	2fn1B-5jzdA: 40.5	2fn1B-5jzdA: 28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R75_A_BEZA701_0 (ANTHRANILATE/PARA-AM INOBENZOATE SYNTHASES COMPONENT I)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	7 / 12	GLU A 197 GLY A 214 GLU A 241 HIS A 276 ARG A 347 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 (-3.5A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.48A	3r75A-5jzdA: 39.4	3r75A-5jzdA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R75_B_BEZB701_0 (ANTHRANILATE/PARA-AM INOBENZOATE SYNTHASES COMPONENT I)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	7 / 12	GLU A 197 GLY A 214 GLU A 241 HIS A 276 ARG A 347 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 (-3.5A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.48A	3r75B-5jzdA: 39.2	3r75B-5jzdA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R76_A_BEZA701_0 (ANTHRANILATE/PARA-AM INOBENZOATE SYNTHASES COMPONENT I)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	7 / 11	GLU A 197 GLY A 214 GLU A 241 HIS A 276 ARG A 347 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 (-3.5A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.45A	3r76A-5jzdA: 39.4	3r76A-5jzdA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R76_B_BEZB701_0 (ANTHRANILATE/PARA-AM INOBENZOATE SYNTHASES COMPONENT I)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	7 / 11	GLU A 197 GLY A 214 GLU A 241 HIS A 276 ARG A 347 GLU A 376 LYS A 380	ISC A 401 (-3.0A) ISC A 401 (-3.2A) MG A 402 ( 2.4A) ISC A 401 (-3.5A) ISC A 401 (-3.5A) MG A 402 ( 2.6A) ISC A 401 (-3.0A)	0.48A	3r76B-5jzdA: 39.3	3r76B-5jzdA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V8V_A_SAMA801_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L)	5eso	2-SUCCINYL-5-ENOLPYR UVYL-6-HYDROXY-3-CYC LOHEXENE-1-CARBOXYLA TE SYNTHASE (Mycobacterium tuberculosis)	5 / 12	MET A 77 GLY A 28 SER A 29 VAL A 75 LEU A 86	None ISC A 602 (-3.6A) ISC A 602 (-4.5A) None None	1.18A	3v8vA-5esoA: 3.7	3v8vA-5esoA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ARC_A_LEUA1001_0 (LEUCINE--TRNA LIGASE)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	4 / 7	LEU A 232 ASP A 238 SER A 215 HIS A 276	None None ISC A 401 (-2.7A) ISC A 401 (-3.5A)	1.34A	4arcA-5jzdA: undetectable	4arcA-5jzdA: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA4)	5jzd	ISOCHORISMATE SYNTHASE ENTC (Escherichia coli)	4 / 7	GLY A 214 ASP A 238 GLY A 363 GLU A 373	ISC A 401 (-3.2A) None ISC A 401 (-3.3A) MG A 402 ( 4.5A)	0.91A	4koeA-5jzdA: undetectable 4koeB-5jzdA: 1.3 4koeD-5jzdA: undetectable	4koeA-5jzdA: 22.68 4koeB-5jzdA: 22.68 4koeD-5jzdA: 20.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I7Q_A_BEZA1501_0","ANTHRANILATE SYNTHASE","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",9,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;LEU A 304;ARG A 347;GLY A 363;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 ( 4.4A);ISC A 401 (-3.5A);ISC A 401 (-3.3A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.48A","1i7qA-5jzdA:36.1",null],["1I7Q_C_BEZC1502_0","ANTHRANILATE SYNTHASE","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",8,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;ARG A 347;GLY A 363;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 (-3.5A);ISC A 401 (-3.3A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.45A","1i7qC-5jzdA:24.5","1i7qA-5jzdA:25.61"],["2BXE_A_1FLA2001_1","SERUM ALBUMIN","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",5,"ARG A 347;VAL A 149;GLY A 363;LEU A 304;SER A 195","ISC A 401 (-3.5A);None;ISC A 401 (-3.3A);ISC A 401 ( 4.4A);None","1.07A","2bxeA-5jzdA:undetectable","1i7qC-5jzdA:25.61"],["2FN1_A_SALA506_1","SALICYLATE SYNTHETASE, IRP9","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",8,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;ARG A 347;GLY A 363;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 (-3.5A);ISC A 401 (-3.3A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.49A","2fn1A-5jzdA:40.2","2bxeA-5jzdA:23.70"],["2FN1_B_SALB503_1","SALICYLATE SYNTHETASE, IRP9","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",8,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;ARG A 347;GLY A 363;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 (-3.5A);ISC A 401 (-3.3A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.53A","2fn1B-5jzdA:40.5","2fn1A-5jzdA:28.48"],["3R75_A_BEZA701_0","ANTHRANILATE\/PARA-AMINOBENZOATE SYNTHASES COMPONENT I","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",7,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;ARG A 347;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 (-3.5A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.48A","3r75A-5jzdA:39.4","2fn1B-5jzdA:28.48"],["3R75_B_BEZB701_0","ANTHRANILATE\/PARA-AMINOBENZOATE SYNTHASES COMPONENT I","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",7,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;ARG A 347;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 (-3.5A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.48A","3r75B-5jzdA:39.2","3r75A-5jzdA:22.27"],["3R76_A_BEZA701_0","ANTHRANILATE\/PARA-AMINOBENZOATE SYNTHASES COMPONENT I","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",7,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;ARG A 347;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 (-3.5A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.45A","3r76A-5jzdA:39.4","3r75B-5jzdA:22.27"],["3R76_B_BEZB701_0","ANTHRANILATE\/PARA-AMINOBENZOATE SYNTHASES COMPONENT I","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",7,"GLU A 197;GLY A 214;GLU A 241;HIS A 276;ARG A 347;GLU A 376;LYS A 380","ISC A 401 (-3.0A);ISC A 401 (-3.2A); MG A 402 ( 2.4A);ISC A 401 (-3.5A);ISC A 401 (-3.5A); MG A 402 ( 2.6A);ISC A 401 (-3.0A)","0.48A","3r76B-5jzdA:39.3","3r76A-5jzdA:22.27"],["3V8V_A_SAMA801_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L","5eso","2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE","Mycobacterium tuberculosis",5,"MET A  77;GLY A  28;SER A  29;VAL A  75;LEU A  86","None;ISC A 602 (-3.6A);ISC A 602 (-4.5A);None;None","1.18A","3v8vA-5esoA:3.7","3r76B-5jzdA:22.27"],["4ARC_A_LEUA1001_0","LEUCINE--TRNA LIGASE","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",4,"LEU A 232;ASP A 238;SER A 215;HIS A 276","None;None;ISC A 401 (-2.7A);ISC A 401 (-3.5A)","1.34A","4arcA-5jzdA:undetectable","3v8vA-5esoA:24.10"],["4KOE_H_TR6H101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA4","5jzd","ISOCHORISMATE SYNTHASE ENTC","Escherichia coli",4,"GLY A 214;ASP A 238;GLY A 363;GLU A 373","ISC A 401 (-3.2A);None;ISC A 401 (-3.3A); MG A 402 ( 4.5A)","0.91A","4koeA-5jzdA:undetectable;4koeB-5jzdA:1.3;4koeD-5jzdA:undetectable","4arcA-5jzdA:18.58"]]