SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IRP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_A_SAMA500_1 (PCZA361.24)	1cjb	PROTEIN (HYPOXANTHINE-GUANIN E PHOSPHORIBOSYLTRANSF ERASE) (Plasmodium falciparum)	3 / 3	ARG A 80 GLU A 144 ASP A 148	None IRP A 300 (-2.8A) IRP A 300 (-3.8A)	0.89A	3g2oA-1cjbA: undetectable	3g2oA-1cjbA: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_A_1N1A1000_2 (P38A)	1cjb	PROTEIN (HYPOXANTHINE-GUANIN E PHOSPHORIBOSYLTRANSF ERASE) (Plasmodium falciparum)	3 / 3	GLU A 144 LEU A 153 LEU A 180	IRP A 300 (-2.8A) None None	0.71A	3ohtA-1cjbA: undetectable	3ohtA-1cjbA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_B_1N1B1000_2 (P38A)	1cjb	PROTEIN (HYPOXANTHINE-GUANIN E PHOSPHORIBOSYLTRANSF ERASE) (Plasmodium falciparum)	3 / 3	GLU A 144 LEU A 153 LEU A 180	IRP A 300 (-2.8A) None None	0.76A	3ohtB-1cjbA: undetectable	3ohtB-1cjbA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EOH_B_TEPB402_1 (PYRIDOXAL KINASE)	1cjb	PROTEIN (HYPOXANTHINE-GUANIN E PHOSPHORIBOSYLTRANSF ERASE) (Plasmodium falciparum)	4 / 5	SER A 202 TYR A 201 VAL A 143 ASP A 145	None None None IRP A 300 (-2.6A)	1.46A	4eohB-1cjbA: undetectable	4eohB-1cjbA: 21.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3G2O_A_SAMA500_1","PCZA361.24","1cjb","PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE)","Plasmodium falciparum",3,"ARG A  80;GLU A 144;ASP A 148","None;IRP A 300 (-2.8A);IRP A 300 (-3.8A)","0.89A","3g2oA-1cjbA:undetectable",null],["3OHT_A_1N1A1000_2","P38A","1cjb","PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE)","Plasmodium falciparum",3,"GLU A 144;LEU A 153;LEU A 180","IRP A 300 (-2.8A);None;None","0.71A","3ohtA-1cjbA:undetectable","3g2oA-1cjbA:18.83"],["3OHT_B_1N1B1000_2","P38A","1cjb","PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE)","Plasmodium falciparum",3,"GLU A 144;LEU A 153;LEU A 180","IRP A 300 (-2.8A);None;None","0.76A","3ohtB-1cjbA:undetectable","3ohtA-1cjbA:22.32"],["4EOH_B_TEPB402_1","PYRIDOXAL KINASE","1cjb","PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE)","Plasmodium falciparum",4,"SER A 202;TYR A 201;VAL A 143;ASP A 145","None;None;None;IRP A 300 (-2.6A)","1.46A","4eohB-1cjbA:undetectable","3ohtB-1cjbA:22.32"]]