SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IPW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		4 / 7 VAL A 318
VAL A 328
ARG A 388
LEU A 396
 None
None
None
IPW  A 601 (-4.5A)
 0.92A 1iepB-5kbrA:
17.2		 1iepB-5kbrA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
GLY A 350
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 ( 3.8A)
None
 1.03A 1opjB-5kbrA:
21.2		 1opjB-5kbrA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		4 / 7 VAL A 318
VAL A 342
TYR A 346
ARG A 388
 None
IPW  A 601 ( 4.4A)
IPW  A 601 (-4.5A)
None
 0.99A 1t46A-5kbrA:
21.2		 1t46A-5kbrA:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		4 / 6 ILE A 276
VAL A 284
ILE A 327
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.2A)
None
None
 0.74A 1uwhA-5kbrA:
23.7		 1uwhA-5kbrA:
29.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		4 / 7 ILE A 276
LYS A 299
ILE A 327
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.5A)
None
None
 0.82A 1uwjA-5kbrA:
7.4		 1uwjA-5kbrA:
30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ALA A 297
GLY A 350
ASP A 354
LEU A 396
THR A 406
PHE A 408
 IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
None
 0.79A 1xkkA-5kbrA:
22.3		 1xkkA-5kbrA:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 11 GLY A 277
VAL A 284
ALA A 297
TYR A 346
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.43A 2evaA-5kbrA:
19.0		 2evaA-5kbrA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.98A 2hyyA-5kbrA:
22.0		 2hyyA-5kbrA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 1.01A 2hyyB-5kbrA:
22.0		 2hyyB-5kbrA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
LYS A 299
GLY A 350
ASP A 354
LEU A 396
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.74A 2itzA-5kbrA:
23.6		 2itzA-5kbrA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
LYS A 299
MET A 319
GLY A 350
LEU A 396
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.74A 2itzA-5kbrA:
23.6		 2itzA-5kbrA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.67A 2oiqA-5kbrA:
22.4		 2oiqA-5kbrA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ILE A 276
ALA A 297
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.45A 2y6oA-5kbrA:
22.5		 2y6oA-5kbrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 10 ILE A 276
VAL A 284
ALA A 297
GLY A 350
ASP A 354
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
 0.64A 2y7jC-5kbrA:
24.1		 2y7jC-5kbrA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 10 ILE A 276
VAL A 284
ALA A 297
GLY A 350
ASP A 354
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
 0.73A 2y7jD-5kbrA:
16.2		 2y7jD-5kbrA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
LYS A 299
GLY A 350
LEU A 396
THR A 406
PHE A 408
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
None
 0.82A 3bbtD-5kbrA:
22.3		 3bbtD-5kbrA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
GLU A 315
VAL A 318
MET A 319
GLY A 350
HIS A 387
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
 0.83A 3cs9A-5kbrA:
21.8		 3cs9A-5kbrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 12 ALA A 297
GLU A 315
VAL A 318
MET A 319
GLY A 350
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
 0.58A 3cs9B-5kbrA:
22.3		 3cs9B-5kbrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 12 ALA A 297
VAL A 318
MET A 319
GLY A 350
HIS A 387
 IPW  A 601 (-3.5A)
None
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
None
 0.84A 3cs9B-5kbrA:
22.3		 3cs9B-5kbrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ALA A 297
GLU A 315
VAL A 318
MET A 319
HIS A 387
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
None
None
 1.22A 3cs9C-5kbrA:
22.0		 3cs9C-5kbrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ALA A 297
GLU A 315
VAL A 318
MET A 319
LEU A 405
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
None
None
 1.13A 3cs9C-5kbrA:
22.0		 3cs9C-5kbrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 GLY A 277
GLY A 279
GLY A 282
VAL A 284
ALA A 297
LYS A 299
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
None
None
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.69A 3eygA-5kbrA:
23.5		 3eygA-5kbrA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		9 / 12 GLY A 277
GLY A 279
GLY A 282
VAL A 284
ALA A 297
LYS A 299
TYR A 346
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
None
None
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.83A 3fupA-5kbrA:
23.0		 3fupA-5kbrA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 GLY A 277
GLY A 279
VAL A 284
ALA A 297
TYR A 346
LEU A 347
LEU A 396
 IPW  A 601 ( 3.9A)
None
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
 0.54A 3fupB-5kbrA:
23.3		 3fupB-5kbrA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.49A 3g5dA-5kbrA:
24.4		 3g5dA-5kbrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.60A 3g5dB-5kbrA:
24.3		 3g5dB-5kbrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
None
 0.99A 3gvuA-5kbrA:
10.0		 3gvuA-5kbrA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 12 ALA A 297
GLU A 315
MET A 319
HIS A 387
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
 0.69A 3ik3B-5kbrA:
21.5		 3ik3B-5kbrA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
LYS A 299
GLU A 315
MET A 319
VAL A 328
TYR A 346
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
 0.64A 3k54A-5kbrA:
23.4		 3k54A-5kbrA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.53A 3k54A-5kbrA:
23.4		 3k54A-5kbrA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 1.02A 3k5vA-5kbrA:
21.2		 3k5vA-5kbrA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 1.02A 3k5vB-5kbrA:
21.3		 3k5vB-5kbrA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 GLY A 277
GLY A 279
VAL A 284
ALA A 297
LYS A 299
TYR A 346
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
None
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.58A 3lxnA-5kbrA:
23.6		 3lxnA-5kbrA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ALA A 297
GLU A 315
MET A 319
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.89A 3mssD-5kbrA:
22.0		 3mssD-5kbrA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.70A 3octA-5kbrA:
9.4		 3octA-5kbrA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.91A 3oezA-5kbrA:
22.3		 3oezA-5kbrA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.67A 3oezA-5kbrA:
22.3		 3oezA-5kbrA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
GLU A 315
VAL A 318
MET A 319
TYR A 346
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
 0.65A 3oezB-5kbrA:
22.8		 3oezB-5kbrA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
GLU A 315
MET A 319
VAL A 328
GLY A 350
HIS A 387
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 ( 3.8A)
None
None
 1.10A 3oxzA-5kbrA:
22.2		 3oxzA-5kbrA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ALA A 297
GLU A 315
MET A 319
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.93A 3pyyA-5kbrA:
22.0		 3pyyA-5kbrA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
None
 1.01A 3pyyB-5kbrA:
21.9		 3pyyB-5kbrA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.65A 3qlgA-5kbrA:
23.1		 3qlgA-5kbrA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
TYR A 346
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
 0.63A 3qlgB-5kbrA:
24.4		 3qlgB-5kbrA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.50A 3qlgB-5kbrA:
24.4		 3qlgB-5kbrA:
27.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.46A 3sxrA-5kbrA:
24.3		 3sxrA-5kbrA:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.45A 3sxrB-5kbrA:
23.9		 3sxrB-5kbrA:
30.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.66A 3ue4B-5kbrA:
23.4		 3ue4B-5kbrA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
LYS A 299
MET A 344
GLY A 350
ASP A 354
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
 0.78A 3ug2A-5kbrA:
20.0		 3ug2A-5kbrA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 1.15A 4bkjA-5kbrA:
21.1		 4bkjA-5kbrA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 10 GLY A 277
VAL A 284
ALA A 297
TYR A 346
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.51A 4ckjA-5kbrA:
13.3		 4ckjA-5kbrA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 0.99A 4csvA-5kbrA:
22.9		 4csvA-5kbrA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 VAL A 284
ALA A 297
LYS A 299
GLY A 350
LEU A 396
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.55A 4hjoA-5kbrA:
22.4		 4hjoA-5kbrA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 GLY A 277
VAL A 284
ALA A 297
LYS A 299
MET A 344
GLY A 350
LEU A 396
THR A 406
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.52A 4i22A-5kbrA:
21.7		 4i22A-5kbrA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 10 ILE A 276
ALA A 297
VAL A 328
MET A 344
LEU A 347
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.2A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.53A 4ks8A-5kbrA:
36.5		 4ks8A-5kbrA:
48.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
 0.64A 4mxoA-5kbrA:
24.0		 4mxoA-5kbrA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 ALA A 297
LYS A 299
GLU A 315
MET A 319
VAL A 328
TYR A 346
LEU A 396
THR A 406
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.62A 4mxxA-5kbrA:
24.0		 4mxxA-5kbrA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
THR A 406
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.65A 4mxxA-5kbrA:
24.0		 4mxxA-5kbrA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
VAL A 328
TYR A 346
GLY A 350
LEU A 396
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.80A 4mxxB-5kbrA:
22.6		 4mxxB-5kbrA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
VAL A 328
MET A 344
TYR A 346
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.62A 4mxyA-5kbrA:
24.4		 4mxyA-5kbrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
VAL A 328
MET A 344
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.62A 4mxyB-5kbrA:
13.7		 4mxyB-5kbrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
VAL A 328
MET A 344
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 0.67A 4mxyB-5kbrA:
13.7		 4mxyB-5kbrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
VAL A 328
MET A 344
TYR A 346
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.62A 4mxzA-5kbrA:
24.4		 4mxzA-5kbrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
VAL A 328
MET A 344
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.62A 4mxzB-5kbrA:
13.7		 4mxzB-5kbrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 VAL A 284
ALA A 297
LYS A 299
VAL A 328
MET A 344
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 0.67A 4mxzB-5kbrA:
13.7		 4mxzB-5kbrA:
27.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 ILE A 276
ALA A 297
LYS A 299
GLU A 315
MET A 344
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 0.98A 4qmnA-5kbrA:
34.9		 4qmnA-5kbrA:
42.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		9 / 11 ILE A 276
ALA A 297
LYS A 299
GLU A 315
MET A 344
TYR A 346
LEU A 347
LEU A 396
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
None
 0.66A 4qmsA-5kbrA:
35.1		 4qmsA-5kbrA:
42.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 12 ILE A 276
GLY A 277
VAL A 284
ALA A 297
MET A 344
TYR A 346
LEU A 347
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
 0.52A 4qmzA-5kbrA:
18.4		 4qmzA-5kbrA:
42.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 12 ALA A 297
GLU A 315
MET A 319
LEU A 380
ARG A 388
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
None
 0.88A 4qrcA-5kbrA:
22.3		 4qrcA-5kbrA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		4 / 5 VAL A 328
VAL A 342
TYR A 346
ARG A 388
 None
IPW  A 601 ( 4.4A)
IPW  A 601 (-4.5A)
None
 0.73A 4r7iA-5kbrA:
21.2		 4r7iA-5kbrA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ALA A 297
GLU A 315
MET A 319
HIS A 387
LEU A 396
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
None
 1.04A 4tyjA-5kbrA:
22.1		 4tyjA-5kbrA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		8 / 11 GLY A 279
VAL A 284
ALA A 297
TYR A 346
GLY A 350
ASN A 394
LEU A 396
ASP A 407
 None
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
None
 0.53A 4u5jA-5kbrA:
24.6		 4u5jA-5kbrA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 12 ALA A 297
GLU A 315
MET A 319
LEU A 380
HIS A 387
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
None
 0.79A 4v01B-5kbrA:
22.2		 4v01B-5kbrA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 10 VAL A 284
LYS A 299
MET A 319
TYR A 346
ARG A 388
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 1.15A 4v04B-5kbrA:
22.0		 4v04B-5kbrA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
LYS A 299
MET A 319
GLY A 350
ASP A 354
LEU A 396
THR A 406
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.84A 4wkqA-5kbrA:
24.1		 4wkqA-5kbrA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.49A 4xliA-5kbrA:
24.6		 4xliA-5kbrA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.61A 4xliB-5kbrA:
24.3		 4xliB-5kbrA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ILE A 276
ALA A 297
LYS A 299
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.71A 5i9xA-5kbrA:
22.3		 5i9xA-5kbrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ILE A 276
ALA A 297
LYS A 299
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.0A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.66A 5i9yA-5kbrA:
22.1		 5i9yA-5kbrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 10 VAL A 284
ALA A 297
VAL A 328
MET A 344
TYR A 346
LEU A 396
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.77A 5n3hA-5kbrA:
26.6		 5n3hA-5kbrA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 ALA A 297
GLU A 315
MET A 319
VAL A 328
GLY A 350
LEU A 396
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.61A 5te0A-5kbrA:
23.7		 5te0A-5kbrA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 ILE A 276
GLY A 277
ALA A 297
GLU A 315
TYR A 346
GLY A 350
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 ( 3.9A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
None
 0.77A 5vc3A-5kbrA:
25.2		 5vc3A-5kbrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 9 ALA A 297
VAL A 328
MET A 344
GLY A 349
THR A 406
 IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.7A)
 0.97A 5w5vA-5kbrA:
11.1		 5w5vA-5kbrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 9 ALA A 297
VAL A 328
MET A 344
GLY A 350
THR A 406
 IPW  A 601 (-3.5A)
None
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-3.7A)
 0.44A 5w5vA-5kbrA:
11.1		 5w5vA-5kbrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 GLY A 277
VAL A 284
ALA A 297
LYS A 299
LEU A 396
THR A 406
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.53A 5yu9A-5kbrA:
21.6		 5yu9A-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 GLY A 277
VAL A 284
ALA A 297
ASP A 354
LEU A 396
THR A 406
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.70A 5yu9B-5kbrA:
21.7		 5yu9B-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 GLY A 277
VAL A 284
ALA A 297
LYS A 299
LEU A 396
THR A 406
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.61A 5yu9B-5kbrA:
21.7		 5yu9B-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		5 / 12 VAL A 284
ALA A 297
GLY A 350
ASP A 354
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-3.7A)
 0.68A 5yu9C-5kbrA:
21.4		 5yu9C-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		6 / 12 VAL A 284
ALA A 297
GLY A 350
ASP A 354
LEU A 396
THR A 406
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.72A 5yu9D-5kbrA:
21.8		 5yu9D-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.72A 6bsdA-5kbrA:
21.1		 6bsdA-5kbrA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
None
 1.08A 6hd4B-5kbrA:
21.3		 6hd4B-5kbrA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens) 		7 / 12 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
None
 1.08A 6hd6B-5kbrA:
21.3		 6hd6B-5kbrA:
13.28