SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IPT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4oue PUTATIVE LIPOPROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 236
GLY A 232
ILE A 303
ASP A 277
VAL A 278
 None
None
None
IPT  A 502 (-2.9A)
None
 0.98A 2oxtC-4oueA:
undetectable		 2oxtC-4oueA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 SER A 191
ASP A 149
ASN A 125
 IPT  A 998 ( 4.6A)
IPT  A 998 (-3.2A)
IPT  A 998 ( 4.7A)
 0.91A 3lsfB-1tlfA:
undetectable
3lsfE-1tlfA:
3.5		 3lsfB-1tlfA:
23.65
3lsfE-1tlfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		3 / 3 ASP A 149
ASN A 125
SER A 191
 IPT  A 998 (-3.2A)
IPT  A 998 ( 4.7A)
IPT  A 998 ( 4.6A)
 0.89A 3lsfB-1tlfA:
undetectable
3lsfE-1tlfA:
3.5		 3lsfB-1tlfA:
23.65
3lsfE-1tlfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		5 / 7 VAL A  99
ALA A 106
LEU A 114
ASP A 149
LEU A 128
 None
None
None
IPT  A 998 (-3.2A)
None
 1.39A 4l9iA-1tlfA:
undetectable		 4l9iA-1tlfA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1tlf LAC REPRESSOR
(Escherichia
coli) 		4 / 8 ASN A 125
GLN A 291
PRO A  76
ILE A  79
 IPT  A 998 ( 4.7A)
IPT  A 998 ( 4.7A)
IPT  A 998 (-3.8A)
None
 0.95A 6hzpA-1tlfA:
undetectable		 6hzpA-1tlfA:
20.52