SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IPR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q8J_A_C2FA801_0 (5-METHYLTETRAHYDROFO LATE S-HOMOCYSTEINE METHYLTRANSFERASE)	5hxt	(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Solanum habrochaites)	5 / 12	GLU A 133 ILE A 207 ASP A 206 GLY A 202 SER A 131	None None None None IPR A 403 (-2.9A)	1.42A	1q8jA-5hxtA: undetectable	1q8jA-5hxtA: 17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_A_C2FA300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5hxt	(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Solanum habrochaites)	5 / 12	GLU A 133 ILE A 207 ASP A 206 GLY A 202 SER A 131	None None None None IPR A 403 (-2.9A)	1.39A	4djfA-5hxtA: undetectable	4djfA-5hxtA: 23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_C_ADNC401_2 (ADENOSINE KINASE)	5hxt	(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Solanum habrochaites)	4 / 5	ASN A 200 LEU A 199 SER A 131 LEU A 145	None None IPR A 403 (-2.9A) None	1.11A	4n09C-5hxtA: undetectable	4n09C-5hxtA: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KB5_A_ADNA401_2 (ADENOSINE KINASE)	5hxt	(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC (Solanum habrochaites)	4 / 4	ASN A 200 LEU A 199 SER A 131 LEU A 145	None None IPR A 403 (-2.9A) None	1.02A	5kb5A-5hxtA: undetectable	5kb5A-5hxtA: 20.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q8J_A_C2FA801_0","5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINE METHYLTRANSFERASE","5hxt","(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Solanum habrochaites",5,"GLU A 133;ILE A 207;ASP A 206;GLY A 202;SER A 131","None;None;None;None;IPR A 403 (-2.9A)","1.42A","1q8jA-5hxtA:undetectable",null],["4DJF_A_C2FA300_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","5hxt","(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Solanum habrochaites",5,"GLU A 133;ILE A 207;ASP A 206;GLY A 202;SER A 131","None;None;None;None;IPR A 403 (-2.9A)","1.39A","4djfA-5hxtA:undetectable","1q8jA-5hxtA:17.35"],["4N09_C_ADNC401_2","ADENOSINE KINASE","5hxt","(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Solanum habrochaites",4,"ASN A 200;LEU A 199;SER A 131;LEU A 145","None;None;IPR A 403 (-2.9A);None","1.11A","4n09C-5hxtA:undetectable","4djfA-5hxtA:23.29"],["5KB5_A_ADNA401_2","ADENOSINE KINASE","5hxt","(2Z,6Z)-FARNESYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC","Solanum habrochaites",4,"ASN A 200;LEU A 199;SER A 131;LEU A 145","None;None;IPR A 403 (-2.9A);None","1.02A","5kb5A-5hxtA:undetectable","4n09C-5hxtA:21.19"]]