SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IPL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Thermus
thermophilus) 		5 / 8 LEU A 236
ILE A  62
GLY A  49
ILE A  48
LEU A 232
 None
IPL  A1001 ( 4.2A)
None
None
None
 1.16A 2o4nB-1wxjA:
undetectable		 2o4nB-1wxjA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Thermus
thermophilus) 		5 / 12 VAL A 123
GLY A  49
ILE A  62
SER A  66
GLN A  63
 None
None
IPL  A1001 ( 4.2A)
None
None
 1.49A 3bwyA-1wxjA:
undetectable		 3bwyA-1wxjA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Thermus
thermophilus) 		5 / 12 VAL A 123
GLY A  49
ILE A  62
SER A  66
GLN A  63
 None
None
IPL  A1001 ( 4.2A)
None
None
 1.49A 4xueB-1wxjA:
undetectable		 4xueB-1wxjA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Thermus
thermophilus) 		5 / 12 ALA A 223
PHE A  95
GLY A 208
GLY A 169
VAL A 148
 None
None
IPL  A1001 (-3.8A)
None
None
 0.89A 5i73A-1wxjA:
undetectable		 5i73A-1wxjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Thermus
thermophilus) 		5 / 9 ALA A  16
VAL A 205
ALA A 206
VAL A 194
GLY A 208
 None
None
None
None
IPL  A1001 (-3.8A)
 1.25A 6bklA-1wxjA:
undetectable
6bklB-1wxjA:
undetectable
6bklC-1wxjA:
undetectable
6bklD-1wxjA:
undetectable		 6bklA-1wxjA:
5.90
6bklB-1wxjA:
5.90
6bklC-1wxjA:
5.90
6bklD-1wxjA:
5.90