SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IPH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.00A 1fohA-1fohA:
70.0		 1fohA-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.24A 1fohA-1fohA:
70.0		 1fohA-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.00A 1fohB-1fohA:
68.1		 1fohB-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.23A 1fohB-1fohA:
68.1		 1fohB-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.14A 1fohC-1fohA:
57.0		 1fohC-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.24A 1fohC-1fohA:
57.0		 1fohC-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.18A 1fohD-1fohA:
57.1		 1fohD-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.26A 1fohD-1fohA:
57.1		 1fohD-1fohA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 PHE A 445
PHE A 418
LEU A 104
PHE A 414
GLY A 367
 None
None
None
None
IPH  A 802 (-3.7A)
 1.11A 1igxA-1fohA:
0.0		 1igxA-1fohA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 11 THR A 182
GLU A 244
MET A 177
GLU A 176
ILE A  81
 None
None
IPH  A 801 (-3.2A)
None
None
 1.39A 1odiE-4hdsA:
undetectable		 1odiE-4hdsA:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.12A 1pn0A-1fohA:
66.8		 1pn0A-1fohA:
98.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.08A 1pn0B-1fohA:
66.5		 1pn0B-1fohA:
98.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.19A 1pn0C-1fohA:
56.6		 1pn0C-1fohA:
98.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.18A 1pn0D-1fohA:
56.6		 1pn0D-1fohA:
98.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4i7l LYSOZYME
(Escherichia
virus
T4) 		5 / 12 ALA A 129
PHE A 153
LEU A 133
ALA A 130
ILE A  78
 None
IPH  A 202 (-4.4A)
None
BME  A 210 ( 4.3A)
IPH  A 202 ( 4.5A)
 1.00A 2aclA-4i7lA:
undetectable
2aclE-4i7lA:
undetectable		 2aclA-4i7lA:
21.05
2aclE-4i7lA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4i7l LYSOZYME
(Escherichia
virus
T4) 		4 / 6 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 IPH  A 202 (-4.4A)
IPH  A 202 ( 4.4A)
None
None
 1.02A 2e1qC-4i7lA:
undetectable		 2e1qC-4i7lA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4hds ARSA
(Sporomusa
ovata) 		4 / 7 TYR A  79
TYR A  91
GLU A 176
GLY A 318
 IPH  A 801 ( 4.0A)
None
None
None
 1.16A 2ha4B-4hdsA:
2.9		 2ha4B-4hdsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5kbe MOPR
(Acinetobacter
calcoaceticus) 		5 / 12 TYR A 176
PHE A  99
ILE A 191
ALA A  83
SER A 166
 IPH  A 602 (-4.8A)
IPH  A 602 ( 4.8A)
None
None
IPH  A 602 (-3.6A)
 1.07A 3apwA-5kbeA:
undetectable		 3apwA-5kbeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4i7l LYSOZYME
(Escherichia
virus
T4) 		4 / 8 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 IPH  A 202 (-4.4A)
IPH  A 202 ( 4.4A)
None
None
 1.02A 3ax7A-4i7lA:
undetectable		 3ax7A-4i7lA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 ASN A 449
GLY A 448
ASP A 102
VAL A 114
GLY A 367
 None
None
None
None
IPH  A 802 (-3.7A)
 1.27A 3k13B-1fohA:
undetectable		 3k13B-1fohA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5kbe MOPR
(Acinetobacter
calcoaceticus) 		4 / 4 GLY A  75
TYR A 161
GLY A  79
ASP A  82
 None
IPH  A 602 ( 4.8A)
None
None
 1.22A 3kl3A-5kbeA:
undetectable		 3kl3A-5kbeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 LEU A 650
TYR A 654
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.83A 4f3tA-5weaA:
59.2		 4f3tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 1.06A 4olaA-5weaA:
61.6		 4olaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.46A 4olaA-5weaA:
61.6		 4olaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.93A 4olbA-5weaA:
59.0		 4olbA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
ILE A 651
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
IPH  A 901 ( 4.7A)
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.67A 4w5nA-5weaA:
60.4		 4w5nA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.76A 4w5nA-5weaA:
60.4		 4w5nA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 TYR A 654
LYS A 660
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.92A 4w5oA-5weaA:
58.7		 4w5oA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
PRO A 661
LEU A 694
TYR A 698
 None
None
None
IPH  A 901 (-3.9A)
IPH  A 901 ( 4.9A)
 0.71A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 TYR A 654
LYS A 660
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.85A 4w5rA-5weaA:
58.0		 4w5rA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
PRO A 661
GLU A 695
TYR A 698
 None
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.76A 4w5tA-5weaA:
48.7		 4w5tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.80A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.50A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 1.01A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.58A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 TYR A 654
LYS A 660
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.95A 4z4eA-5weaA:
58.8		 4z4eA-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.91A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
99.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.65A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
LYS A 660
PRO A 661
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.92A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
TYR A 654
PRO A 661
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.56A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.91A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.55A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.71A 5js1A-5weaA:
59.0		 5js1A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.27A 5js1A-5weaA:
59.0		 5js1A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 LEU A 650
TYR A 654
LYS A 660
LEU A 694
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 ( 4.9A)
 0.88A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 12 ALA A 690
LEU A 650
ILE A 651
GLY A 616
ILE A 687
 None
IPH  A 901 (-4.7A)
IPH  A 901 ( 4.7A)
None
None
 1.10A 5m24A-5weaA:
undetectable		 5m24A-5weaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 GLU A 282
LEU A  20
ARG A 281
GLY A  55
LEU A  56
 None
None
None
IPH  A 802 ( 3.8A)
None
 1.28A 5m50E-1fohA:
undetectable		 5m50E-1fohA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5kbe MOPR
(Acinetobacter
calcoaceticus) 		5 / 12 ASP A  82
LEU A 159
ALA A 162
SER A 166
GLY A 107
 None
None
IPH  A 602 ( 3.9A)
IPH  A 602 (-3.6A)
None
 1.14A 5m5cB-5kbeA:
undetectable		 5m5cB-5kbeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5kbe MOPR
(Acinetobacter
calcoaceticus) 		5 / 10 ASP A  82
LEU A 159
ALA A 162
SER A 166
GLY A 107
 None
None
IPH  A 602 ( 3.9A)
IPH  A 602 (-3.6A)
None
 1.14A 5m5cE-5kbeA:
undetectable		 5m5cE-5kbeA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.90A 5t7bA-5weaA:
undetectable		 5t7bA-5weaA:
98.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.65A 5t7bA-5weaA:
undetectable		 5t7bA-5weaA:
98.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C
(Drosophila
melanogaster) 		4 / 9 ILE A  17
TYR A 238
ILE A 209
LEU A 210
 NAD  A 302 (-3.8A)
None
IPH  A 303 (-4.0A)
None
 0.81A 5vkqB-5ilgA:
undetectable
5vkqC-5ilgA:
undetectable		 5vkqB-5ilgA:
9.90
5vkqC-5ilgA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 LEU A 650
TYR A 654
LYS A 660
LEU A 694
GLU A 695
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
 0.00A 5weaA-5weaA:
68.4		 5weaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.89A 6cbdA-5weaA:
57.8		 6cbdA-5weaA:
undetectable