SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IPD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 4 GLY A 215
SER A 165
VAL A 175
LEU A 271
 None
IPD  A 281 ( 3.8A)
None
None
 1.36A 1yajB-1awbA:
undetectable		 1yajB-1awbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 6 SER A 124
VAL A 126
THR A 195
ASP A  93
 None
None
None
IPD  A 281 (-3.0A)
 1.24A 2hdnJ-1awbA:
undetectable
2hdnK-1awbA:
0.0
2hdnL-1awbA:
undetectable		 2hdnJ-1awbA:
21.94
2hdnK-1awbA:
9.80
2hdnL-1awbA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 0.99A 2obvA-1awbA:
undetectable		 2obvA-1awbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 8 HIS A 217
VAL A 250
ILE A 216
VAL A 221
LEU A 245
 None
None
IPD  A 281 (-4.9A)
None
None
 1.42A 3kp6A-1awbA:
undetectable
3kp6B-1awbA:
0.0		 3kp6A-1awbA:
19.42
3kp6B-1awbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 ARG A 101
VAL A 198
GLY A 194
VAL A 126
 None
None
IPD  A 281 (-4.3A)
None
 0.82A 3ufnB-1awbA:
0.0		 3ufnB-1awbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 5 SER A 167
GLY A 168
THR A  95
ASP A 170
 IPD  A 304 (-3.9A)
None
None
GOL  A 305 (-3.8A)
 1.14A 4eohA-4rw3A:
undetectable		 4eohA-4rw3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.03A 4kttA-1awbA:
undetectable		 4kttA-1awbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 4kttC-1awbA:
undetectable		 4kttC-1awbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 0.99A 4ndnA-1awbA:
undetectable		 4ndnA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.04A 4ndnC-1awbA:
undetectable		 4ndnC-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.08A 4odjA-1awbA:
undetectable		 4odjA-1awbA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 5a1iA-1awbA:
undetectable		 5a1iA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 5a1iA-1awbA:
undetectable		 5a1iA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 4 PRO A 135
MET A 245
GLY A 243
VAL A  90
 None
IPD  A 304 ( 3.7A)
None
None
 1.01A 6ak3A-4rw3A:
undetectable		 6ak3A-4rw3A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.11A 6fbnB-1awbA:
undetectable		 6fbnB-1awbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 6fboA-1awbA:
undetectable		 6fboA-1awbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 0.98A 6fcbA-1awbA:
undetectable		 6fcbA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 6fcdA-1awbA:
undetectable		 6fcdA-1awbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.01A 6g6rA-1awbA:
undetectable		 6g6rA-1awbA:
18.99