SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'INJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 109
ILE A  31
ARG A  28
TRP A  26
 None
None
None
INJ  A 200 (-3.9A)
 1.44A 1ie9A-1ejbA:
undetectable		 1ie9A-1ejbA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.50A 1kyvA-1ejbA:
25.9
1kyvE-1ejbA:
26.0		 1kyvA-1ejbA:
49.10
1kyvE-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
 0.25A 1kyvA-1ejbA:
25.9
1kyvB-1ejbA:
26.0		 1kyvA-1ejbA:
49.10
1kyvB-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.50A 1kyvB-1ejbA:
26.0
1kyvC-1ejbA:
26.1		 1kyvB-1ejbA:
49.10
1kyvC-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.49A 1kyvC-1ejbA:
26.1
1kyvD-1ejbA:
25.9		 1kyvC-1ejbA:
49.10
1kyvD-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.49A 1kyvD-1ejbA:
25.9
1kyvE-1ejbA:
26.0		 1kyvD-1ejbA:
49.10
1kyvE-1ejbA:
49.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 109
ILE A  31
ARG A  28
TRP A  26
 None
None
None
INJ  A 200 (-3.9A)
 1.43A 2zlcA-1ejbA:
undetectable		 2zlcA-1ejbA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  60
VAL A  35
LEU A  34
ILE A  87
GLY A 123
 INJ  A 200 (-2.8A)
None
None
None
None
 1.01A 4y8wA-1ejbA:
0.0		 4y8wA-1ejbA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  60
VAL A  35
LEU A  34
ILE A  87
GLY A 123
 INJ  A 200 (-2.8A)
None
None
None
None
 1.01A 4y8wB-1ejbA:
0.0		 4y8wB-1ejbA:
16.53